ChemicalBook > CAS DataBase List > 1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone

1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone

Product Name: 1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
CAS No.: 487-49-0
Chemical Name: 1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone
Synonyms: Ononetin;2,4-Dihydroxyphenyl 4-Methoxybenzyl Ketone;4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone;2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone;Ethanone,1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)-;2’, 4’-Dihydroxy-2(4-methoxyphenyl) acetophenone (Ononetin);Inhibitor,Transient receptor potential channels,Ononetin,inhibit,Ca2+,TRP Channel,TRPM3,deoxybenzoin
CBNumber: CB21458187
Molecular Formula: C15H14O4
Formula Weight: 258.27
MOL File: 487-49-0.mol

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1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Property

Melting point:: 158.0 to 162.0 °C
Boiling point:: 464.7±14.0 °C(Predicted)
Density: 1.275±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: 7.65±0.35(Predicted)
color: White to Light yellow to Dark green

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Safety

RTECS: KM5775350
HS Code: 2914.50.3000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4816
Product name: 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone
Purity: >98.0%(T)
Packaging: 1g
Price: $276
Updated: 2025/07/31

TCI Chemical

Product number: D4816
Product name: 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone
Purity: >98.0%(T)
Packaging: 200mg
Price: $80
Updated: 2025/07/31

Tocris

Product number: 5143
Product name: Ononetin
Purity: ≥98%(HPLC)
Packaging: 50
Price: $70
Updated: 2021/12/16

TRC

Product number: O656508
Product name: Ononetin
Packaging: 10mg
Price: $55
Updated: 2021/12/16

Usbiological

Product number: 256112
Product name: Ononetin
Packaging: 50mg
Price: $290
Updated: 2021/12/16

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1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Chemical Properties,Usage,Production

Uses

Ononetin is a potent and selective transient receptor potential TRMP3 blocker and may represent a novel concept for analgesic treatment.

Definition

ChEBI: 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone is a stilbenoid.

Preparation

Preparation by condensation of p-methoxyphenyl-acetonitrile with resorcinol (Hoesch reaction).

in vivo

Ononetin (10 mg/kg, i.p.) treatment completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3^-/- mice is unlikely to be caused by developmental or compensatory mechanisms and suggests that TRPM3 may be a tractable target for inflammatory pain^[2].

IC 50

TRPM3: 0.3 μM (IC₅₀)

storage

Store at +4°C

1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone Suppliers

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487-49-0, 1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanoneRelated Search:

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Ononetin

Ethanone,1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)-

2,4-Dihydroxyphenyl 4-Methoxybenzyl Ketone

2’, 4’-Dihydroxy-2(4-methoxyphenyl) acetophenone (Ononetin)

4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone

Inhibitor,Transient receptor potential channels,Ononetin,inhibit,Ca2+,TRP Channel,TRPM3,deoxybenzoin

2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone

487-49-0