PHYSOSTIGMINE SALICYLATE

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PHYSOSTIGMINE SALICYLATE

Product Name: PHYSOSTIGMINE SALICYLATE
CAS No.: 57-64-7
Chemical Name: PHYSOSTIGMINE SALICYLATE
Synonyms: ESERINE SALICYLATE;Physostigmine-d3 salicylate;ar-44;tl-1380;CCRIS 3405;Isopto Eserine;EINECS 200-343-8;physostolsalicylate;Physostigminsalicylat;ESERINE MONOSALICYLATE
CBNumber: CB2146890
Molecular Formula: C22H27N3O5
Formula Weight: 413.47
MOL File: 57-64-7.mol

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PHYSOSTIGMINE SALICYLATE Property

Melting point:: 181-183 °C
storage temp.: -20°C
solubility: DMF: 30 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
pka: pKa 1.96/8.08(H2O,t =15) (Uncertain)
form: Solid
color: White to yellow
Merck: 7384
BRN: 3900576
InChI: InChI=1/C15H21N3O2.C7H6O3/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2;8-6-4-2-1-3-5(6)7(9)10/h5-6,9,13H,7-8H2,1-4H3,(H,16,19);1-4,8H,(H,9,10)/t13-,15+;/s3
InChIKey: HZOTZTANVBDFOF-DPKVYHSMNA-N
SMILES: C12C=C(C=CC=1N(C)[C@@]1([H])N(CC[C@@]21C)C)OC(=O)NC.C1(C(=O)O)=CC=CC=C1O |&1:8,13,r|
CAS DataBase Reference: 57-64-7(CAS DataBase Reference)
EPA Substance Registry System: Physostigmine salicylate (57-64-7)

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Safety

Hazard Codes: T+
Risk Statements: 26/28
Safety Statements: 25-45
RIDADR: UN 1544 6.1/PG 1
WGK Germany: 3
RTECS: TJ2450000
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 2939800000
Toxicity: LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P1600000
Product name: Physostigmine salicylate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: p1600000
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1537003
Product name: Physostigmine salicylate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

TRC

Product number: P398510
Product name: Physostigmine salicylate
Packaging: 50mg
Price: $765
Updated: 2021/12/16

ChemScene

Product number: CS-0013051
Product name: Physostigmine salicylate
Purity: ≥99.00%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0013051
Product name: Physostigmine salicylate
Purity: ≥99.00%
Packaging: 10mg
Price: $80
Updated: 2021/12/16

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PHYSOSTIGMINE SALICYLATE Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet

Uses

cholinergic, anticholinesterase, miotic

Definition

ChEBI: Physostigmine salicylate is an azaheterocycle salicylate salt and a member of salicylates. It contains a physostigmine.

brand name

Antilirium (Forest); Isopto Eserine (Alcon).

General Description

The salicylate ofphysostigmine (eserine salicylate) may be prepared byneutralizing an ethereal solution of the alkaloid with anethereal solution of salicylic acid. Excess salicylic acid isremoved from the precipitated product by washing itwith ether. The salicylate is less deliquescent than thesulfate.
Physostigmine salicylate occurs as a white, shining,odorless crystal or white powder that is soluble in water(1:75), alcohol (1:16), or chloroform (1:6) but much lesssoluble in ether (1:250). On prolonged exposure to air andlight, the crystals turn red. The red may be removed bywashing the crystals with alcohol, although this causes lossof the compound as well. Aqueous solutions are neutral orslightly acidic and take on a red coloration after a period.The coloration may be taken as an index of the loss of activityof physostigmine solutions.

General Description

Crystal form that turns red on exposure to heat or light.

Reactivity Profile

Behaves as a weak acid in solution.

Health Hazard

PHYSOSTIGMINE SALICYLATE is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor.

Fire Hazard

When heated to decomposition, PHYSOSTIGMINE SALICYLATE emits toxic fumes of nitrogen oxides.

Safety Profile

Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects: arrhythmias, nausea or vomiting. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx See also PHYSOSTIGMINE.

PHYSOSTIGMINE SALICYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PHYSOSTIGMINE SALICYLATE manufacturers

Dideu Industries Group Limited

Product: PHYSOSTIGMINE SALICYLATE 57-64-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-27

57-64-7, PHYSOSTIGMINE SALICYLATERelated Search:

Erythromycin Estolate 2-BENZOYLACETANILIDE Pyrrolidine Salicylic acid Piretanide PIRETANIDE IMPURITY A 2-(3-methoxyphenyl)-2-methylpropan-1-amine METOLCARB 1H-Indol-2-amine 3-(3-METHOXYPHENYL)PYRROLIDINE AMINOCARB 2,3-DIHYDROINDOL-5-OL 5-Methoxy-2,3-dihydroindoline PHYSOSTIGMINE PHYSOSTIGMINE SALICYLATE

PHYSOSTIGMINE SALICYLATE SALT

2-hydroxy-,compd.with(3as-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-benzoicaci

ar-44

ESERINE MONOSALICYLATE

ESERINE SALICYLATE

ESERINE SALICYLATE SALT

ESERINE SALICYLATE 99.9%

Physostigmine monosalicylate

Physostigmine salicylate (Eserine salicylate)

Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo2,3-bindol-5-yl methylcarbamate (1:1)

PHYSOSTIGMINESALICYLATE,USP

ESERINE SALICYLATE(RG)

Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1) (9CI)

Benzoic acid, 2-hydroxy-, compd. with (3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1)

Isopto Eserine

Physostigmine salicylate (6CI)

Physostigmine, monosalicylate (8CI)

Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-, mono(2-hydroxybenzoate) (salt) (9CI)

Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-, mono(2-hydroxybenzoate) (salt)

Salicylic acid, compd. with physostigmine (1:1) (8CI)

Physostigminsalicylat

Benzoicacid,2-hydroxy-,cpmpd,with(3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indo1-5-ylmethylcarbamateester(1:1)

physostigmine,[salicylate(1:1)]

physostigmine,salicylate(1:1)

physostolsalicylate

salicylicacid,compd.withphysostigmine(1:1)

tl-1380

trimethylpyrrolo[2,3-b]indol-5-ylmethylcarbamate(1:1)

Physostigmine Salicylate (200 mg)

Physostigmine-d3 salicylate

(3aS,8aR)-1,3a,8-triMethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl MethylcarbaMate 2-hydroxybenzoate

Eserine salicylate salt >=97.0% (N)

Physostigmine salicylate CRS

(?)-Physostigmine (salicylate)

PHYSOSTIGMINE SALICYLATE USP/EP/BP

PHYSOSTIGMINE SALICYLATE INJECTION

Physostigmine Salicylate (1537003)

inhibit,Eserine,antidote,Physostigmine,blood-brain,Physostigmine Salicylate,Alzheimer's,Cholinesterase (ChE),Inhibitor,barrier

CCRIS 3405

EINECS 200-343-8

Physostigmine Salicylate

57-64-7

C22H27N3O5

C15H21N3O2C7H6O3

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