ChemicalBook > CAS DataBase List > 6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
- Product Name
- 6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
- CAS No.
- 147497-32-3
- Chemical Name
- 6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
- Synonyms
- 6-bromo-3,4-dihydroisoquinolin-1(2H)-one;6-broMo-1,2,3,4-tetrahydroisoquinolin-1-one;6-BROMO-3,4-1(1H)-ISOQUINOLINONE;6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ON;6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE;6-BROMO-3,4-DIHYDRO-1(1H)-ISOQUINOLINONE;6-Bromo-3,4-dihydro-1(2H)-isoquinolinone;1(2H)-Isoquinolinone, 6-bromo-3,4-dihydro-;6-BroMo-1-oxo-1,2,3,4-tetrahydroisoquinoline;1(2H)-Isoquinolinone, 6-bromo-3,4-dihydro- , 97%min
- CBNumber
- CB2147125
- Molecular Formula
- C9H8BrNO
- Formula Weight
- 226.07
- MOL File
- 147497-32-3.mol
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6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Property
- Melting point:
- 170.0-173.1 °C
- Boiling point:
- 453.3±45.0 °C(Predicted)
- Density
- 1.559±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder
- pka
- 14.22±0.20(Predicted)
- color
- Yellow
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Safety
- HS Code
- 2933499090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B683520
- Product name
- 6-Bromo-3,4-dihydro-2H-isoquinolin-1-one
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
Ark Pharm
- Product number
- P000213853
- Product name
- 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one
- Purity
- 98%
- Packaging
- 5g
- Price
- $198
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB19108
- Product name
- 6-Bromo-3,4-dihydro-2H-isoquinolin-1-one
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H48-9-96
- Product name
- 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one
- Packaging
- 1g
- Price
- $192
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB19108
- Product name
- 6-Bromo-3,4-dihydro-2H-isoquinolin-1-one
- Packaging
- 2g
- Price
- $320
- Updated
- 2021/12/16
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6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Chemical Properties,Usage,Production
Uses
6-bromo-3,4-dihydroisoquinolin-1(2H)-one is an intermediate used in the synthesis of benzolactams as dopamine D3 receptor ligands.IT is also used in the synthesis of new, selective 3-aminopyrazole based MK2-inhibitors that was proved to inhibit intracellular phosphorylation of hsp27 as well as LPS-induced TNFα release in cells.
Synthesis
34598-49-7
147497-32-3
1. 5-bromo-1-indanone (8a) (1.08 g, 5.1 mmol) was weighed into a 100 mL round bottom flask. 2. dichloromethane (30 mL), methanesulfonic acid (15 mL) and sodium azide (0.5 g, 7.7 mmol) were added sequentially to the reaction flask at 0°C. The reaction was carried out at room temperature. 3. The reaction mixture was stirred at room temperature for 3 hours. 4. Upon completion of the reaction, 1.0 M aqueous sodium hydroxide (50 mL) was slowly added to the reaction solution to quench the reaction. 5. The aqueous phase was extracted with dichloromethane (100 mL x 1) and the organic phases were combined. 6. The organic phase was washed with saturated brine (40 mL×1), dried over anhydrous sodium sulfate and filtered. 7. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, v/v=3:1) to afford 6-bromo-3,4-dihydro-2H-isoquinolin-1-one (8b) as a gray solid (0.45 g, 39% yield).
References
[1] Patent: US2010/4231, 2010, A1. Location in patent: Page/Page column 67-68
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 9, p. 2670 - 2674
[3] Patent: US2016/251376, 2016, A1. Location in patent: Paragraph 0852; 0853; 0854
[4] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0088
[5] Patent: CN107879975, 2018, A. Location in patent: Paragraph 0132; 0134
6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE Preparation Products And Raw materials
Raw materials
Sodium sulfate
Sodium chloride
Triethylamine
Ethyl chloroformate
Polyphosphoric acid
Tetrahydrofuran
Diethyl ether
Ethyl acetate
Lithium Aluminum Hydride
Hydrochloric acid
Sodium bicarbonate
Dichloromethane
Methanol
Sodium hydroxide
Magnesium sulfate
Sulfuric acid
3-Bromophenylacetonitrile
Preparation Products
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View Lastest Price from 6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE manufacturers
Honest Joy Holdings Limited
- Product
- 6-Bromo-3,4-dihydro-2h-isoquinolin-1-one 147497-32-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.6%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08
147497-32-3, 6-BROMO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONERelated Search:
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