Methylene boldenone
- Product Name
- Methylene boldenone
- CAS No.
- 122370-91-6
- Chemical Name
- Methylene boldenone
- Synonyms
- (17β)-;METHYLENE BOLDENONE;17β-Hydroxy Exemestane;17--Hydroxy Exemestane;Exemestane 17β-Hydroxy Impurity;17β-Hydroxy ExeMestane SulfaMate;Exemestane Impurity 23 (Exemestane EP Impurity H);(17)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one;(17b)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one;Androsta-1,4-dien-3-one, 17-hydroxy-6-methylene-, (17β)-
- CBNumber
- CB21478037
- Molecular Formula
- C20H26O2
- Formula Weight
- 298.42
- MOL File
- 122370-91-6.mol
Methylene boldenone Property
- Melting point:
- 134-136°C
- Density
- 1.14
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White
- CAS DataBase Reference
- 122370-91-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27989
- Product name
- 17β-hydroxy Exemestane
- Packaging
- 1mg
- Price
- $263
- Updated
- 2024/03/01
- Product number
- 27989
- Product name
- 17β-hydroxy Exemestane
- Packaging
- 5mg
- Price
- $848
- Updated
- 2024/03/01
- Product number
- H942345
- Product name
- 17β-HydroxyExemestaneSulfamate
- Packaging
- 10mg
- Price
- $1410
- Updated
- 2021/12/16
- Product number
- 70677
- Product name
- 17β-HydroxyExemestaneSulfamate
- Packaging
- 10mg
- Price
- $2280
- Updated
- 2021/12/16
- Product number
- 7621CS
- Product name
- MethyleneBoldenone,
- Packaging
- 5mg
- Price
- $1043
- Updated
- 2021/12/16
Methylene boldenone Chemical Properties,Usage,Production
Description
17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.
Chemical Properties
Off-White Solid
Uses
A metabolite of Exemestane; exerts biological effects as an androgen.
Uses
17β-Hydroxy Exemestane Sulfamate is a metabolite of Exemestane (E957000).