ChemicalBook > CAS DataBase List > Methylene boldenone

Methylene boldenone

Product Name: Methylene boldenone
CAS No.: 122370-91-6
Chemical Name: Methylene boldenone
Synonyms: (17β)-;METHYLENE BOLDENONE;17β-Hydroxy Exemestane;17--Hydroxy Exemestane;Impurity H in ezetimibe;Exemestane 17β-Hydroxy Impurity;17β-Hydroxy ExeMestane SulfaMate;Exemestane Impurity 23 (Exemestane EP Impurity H);(17)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one;(17b)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one
CBNumber: CB21478037
Molecular Formula: C20H26O2
Formula Weight: 298.42
MOL File: 122370-91-6.mol

Less

Methylene boldenone Property

Melting point:: 134-136°C
Density: 1.14
storage temp.: -20°C Freezer
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: Off-White
CAS DataBase Reference: 122370-91-6

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 27989
Product name: 17β-hydroxy Exemestane
Packaging: 1mg
Price: $263
Updated: 2024/03/01

Cayman Chemical

Product number: 27989
Product name: 17β-hydroxy Exemestane
Packaging: 5mg
Price: $848
Updated: 2024/03/01

TRC

Product number: H942345
Product name: 17β-HydroxyExemestaneSulfamate
Packaging: 10mg
Price: $1410
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 70677
Product name: 17β-HydroxyExemestaneSulfamate
Packaging: 10mg
Price: $2280
Updated: 2021/12/16

AK Scientific

Product number: 7621CS
Product name: MethyleneBoldenone,
Packaging: 5mg
Price: $1043
Updated: 2021/12/16

Less

Methylene boldenone Chemical Properties,Usage,Production

Description

17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC₅₀ = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC₅₀ = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC₅₀ = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC₅₀ = 2.7 μM) and T47D breast cancer cells (EC₅₀s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.

Chemical Properties

Off-White Solid

Uses

A metabolite of Exemestane; exerts biological effects as an androgen.

Uses

17β-Hydroxy Exemestane Sulfamate is a metabolite of Exemestane (E957000).

References

[1] PAUL E GOSS. Effects of the steroidal aromatase inhibitor exemestane and the nonsteroidal aromatase inhibitor letrozole on bone and lipid metabolism in ovariectomized rats.[J]. Clinical Cancer Research, 2004, 10 17: 5717-5723. DOI: 10.1158/1078-0432.ccr-04-0438
[2] LANDRY K KAMDEM Z D David A Flockhart. In vitro cytochrome P450-mediated metabolism of exemestane.[J]. Drug Metabolism and Disposition, 2011, 39 1: 98-105. DOI: 10.1124/dmd.110.032276
[3] FRANCO BUZZETTI . Synthesis and aromatase inhibition by potential metabolites of exemestane (6-methylenandrosta-1,4-diene-3,17-dione)[J]. Steroids, 1993, 58 11: Pages 527-532. DOI: 10.1016/0039-128x(93)90029-m
[4] ERIC A ARIAZI. Exemestane’s 17-hydroxylated metabolite exerts biological effects as an androgen.[J]. Molecular Cancer Therapeutics, 2007: 2817-2827. DOI: 10.1158/1535-7163.mct-07-0312
[5] CARLA L. VARELA . Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line[J]. European Journal of Medicinal Chemistry, 2014, 87: Pages 336-345. DOI: 10.1016/j.ejmech.2014.09.074

Methylene boldenone Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Methylene boldenone Suppliers

Canada 2 China 55 India 5 United States 5 Global 67

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5158
Advantage: 50

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1955
Advantage: 55

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Shijiazhuang yaoBo Pharmaceutical Co., Ltd.

Tel: 15633056635
Email: 2880679888@qq.com
Country: China
ProdList: 2373
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-63315541 13323832564
Fax: QQ:3001332135
Email: 3001332135@qq.com
Country: China
ProdList: 9970
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Hefei Molake Biotechnology Co., Ltd.

Tel: 0551-66336380 18956014586
Fax: 055166336380
Email: 983438788@qq.com
Country: China
ProdList: 2297
Advantage: 58

Chengdu MassCale Pharmaceutical Co., Ltd.

Tel: 028-84552636 18084815636
Email: chensfsc@126.com
Country: China
ProdList: 1445
Advantage: 58

CD Chemical Group Limited

Tel: +8615986615575
Fax: 0086-13651442114
Email: info@codchem.com
Country: China
ProdList: 20342
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Beijing xinyanhui pharmaceutical research and development co., LTD

Tel: 13969155946
Email: 1461866103@qq.com
Country: China
ProdList: 16111
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shenzhen ruikai de biotechnology co., ltd.

Tel: 0755-61348847 17820674378
Fax: 0755-21016893
Email: 2682116078@qq.com
Country: China
ProdList: 7843
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

PCL - Business, Laboratory Pharmaceutical

Tel: 19150123681
Fax: QQ:3008022628
Email: Hu.xinyue@purechemland.com
Country: China
ProdList: 3566
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Guangzhou Juntang Technology Co., Ltd

Tel: 020-36607679 13502246435
Email: sales@dmstandards.com
Country: China
ProdList: 10945
Advantage: 58

Foshan Treasure Biotechnology Co., Ltd

Tel: 0757-85921206 18520245316
Email: 2329783215@qq.com
Country: China
ProdList: 12661
Advantage: 58

QUALITY CONTROL SOLUTIONS LTD.

Tel: +86-0755-66853366 +86-13670046396
Email: export03@qcsrm.com
Country: China
ProdList: 24342
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2815987 13927875076
Fax: 0751-2828607
Email: 3007432263@qq.com
Country: China
ProdList: 9963
Advantage: 58

Huaihua Yuanyanda Biotechnology Co., Ltd

Tel: 18711085600
Email: 1652923704@qq.com
Country: China
ProdList: 4628
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Scinova Biotech(Guangzhou) Co., Ltd.

Tel: 13268215580
Email: scinova_sales@163.com
Country: China
ProdList: 7025
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175-877 18933936954
Email: tianwen.zhan@cato-chem.com
Country: China
ProdList: 7259
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 18003
Advantage: 58

LangFangshi Zekang Pharma Tech CO.,Itd.

Tel: 0316-2883536 19333636468
Email: 93618484@qq.com
Country: China
ProdList: 2334
Advantage: 58

Shaanxi Xihua Chemical Industry Co., Ltd

Tel: 029-029-81123119 17391733320
Email: 1021@dideu.com
Country: China
ProdList: 9995
Advantage: 58

Tan-Mo Technology Co., Ltd.

Tel: 19850211281
Email: qiann@gbw-china.com
Country: China
ProdList: 1980
Advantage: 58

Shanghai Zerui Biotechnology Co., Ltd.

Tel: 021-54580889 18321124657
Fax: 021-54580889
Email: 731997554@qq.com
Country: China
ProdList: 10608
Advantage: 58

Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd

Tel: 18162595016; 18162595016
Email: 3287908757@qq.com
Country: China
ProdList: 9119
Advantage: 58

Henan Vcommend Consultrading Co., Ltd.

Tel: 13393721940
Email: sales@vcommend.com
Country: China
ProdList: 9963
Advantage: 58

Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd

Tel: 020-18102736 18102736234
Email: LK@zlstandards.com
Country: China
ProdList: 8206
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

Tanmo Quality Inspection Technology Co., Ltd.

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 6043
Advantage: 58

Huaihua Yuanyanda Biotechnology Co., Ltd

Tel: 18229999901
Email: 18711085600@163.com
Country: China
ProdList: 4590
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Changzhou Xianglong Pharmaceutical Technology Co., Ltd.,

Tel: 18915873328 18915873328
Email: 296197970@qq.com
Country: China
ProdList: 11051
Advantage: 58

Guangdong Yuanfeng Chemical Reagent Co., Ltd

Tel: 13318584237
Email: 3930831290@qq.com
Country: China
ProdList: 3843
Advantage: 58

LangFangshi Hengfuyuan Pharma Tech CO.,Itd.

Tel: 0316-2883536 19333636468
Email: 1877241811@qq.com
Country: China
ProdList: 2181
Advantage: 58

Hangzhou Yiyun Guoke Biotechnology Co., Ltd.

Tel: 17717523804
Email: 1211221625@qq.com
Country: China
ProdList: 8568
Advantage: 58

HUNEI MEIBEI NEW MATERIAL Co., Ltd.

Tel: 18271819653
Email: 1483755123@qq.com
Country: China
ProdList: 3980
Advantage: 58

DAYANG CHEM (HANGZHOU) CO.,LTD

Tel: +86-88938639 +86-17705817739
Email: info@dycnchem.com
Country: China
ProdList: 53899
Advantage: 58

SUZHOU SENFEIDA CHEMICAL CO.,LTD

Tel: +86-0512-83500002 +8618662433356
Email: 3899766280@qq.com
Country: China
ProdList: 26362
Advantage: 58

China National Standard Pharmaceutical Corporation Limited

Tel: +8615391658522
Email: overseasales@yongstandards.com
Country: China
ProdList: 11922
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

122370-91-6, Methylene boldenoneRelated Search:

Methylene Blue trihydrate Boldenone N,N'-Methylenebisacrylamide Dimethyl sulfoxide 4,4'-Diphenylmethane diisocyanate Exemestane Impurity 2 Epoxy Exemestane (6-Alfa Isomer) 6-METHYLENEANDROST-4-ENE-3,17-DIONE Epoxy Exemestane (6-Beta Isomer) ExeMestane Related CoMpound 6-Oxo Boldione Exemestane Exemestane impurity B -F Exemestane EP Impurity C Boldenone undecylenate CHLOROPHOSPHONAZO III Methylene Blue Hexamethylenetetramine

METHYLENE BOLDENONE

(17b)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one

Exemestane 17β-Hydroxy Impurity

(17)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one

17--Hydroxy Exemestane

(17β)-

17β-Hydroxy ExeMestane SulfaMate

Androsta-1,4-dien-3-one, 17-hydroxy-6-methylene-, (17β)-

17β-Hydroxy Exemestane

(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-6-methylene-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

Exemestane Impurity 23 (Exemestane EP Impurity H)

17beta-Hydroxy-6-methylideneandrosta-1,4-dien-3-one (17beta-Hydroxyexemestane)

Impurity H in ezetimibe

17β-Hydroxy-6-methylideneandrosta-1,4-dien-3-one (17β-Hydroxyexemestane)

122370-91-6

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Steroids