ChemicalBook > CAS DataBase List > Methylene boldenone

Methylene boldenone

Product Name
Methylene boldenone
CAS No.
122370-91-6
Chemical Name
Methylene boldenone
Synonyms
(17β)-;METHYLENE BOLDENONE;17β-Hydroxy Exemestane;17--Hydroxy Exemestane;Exemestane 17β-Hydroxy Impurity;17β-Hydroxy ExeMestane SulfaMate;Exemestane Impurity 23 (Exemestane EP Impurity H);(17)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one;(17b)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one;Androsta-1,4-dien-3-one, 17-hydroxy-6-methylene-, (17β)-
CBNumber
CB21478037
Molecular Formula
C20H26O2
Formula Weight
298.42
MOL File
122370-91-6.mol
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Methylene boldenone Property

Melting point:
134-136°C
Density 
1.14
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White
CAS DataBase Reference
122370-91-6
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27989
Product name
17β-hydroxy Exemestane
Packaging
1mg
Price
$263
Updated
2024/03/01
Cayman Chemical
Product number
27989
Product name
17β-hydroxy Exemestane
Packaging
5mg
Price
$848
Updated
2024/03/01
TRC
Product number
H942345
Product name
17β-HydroxyExemestaneSulfamate
Packaging
10mg
Price
$1410
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
70677
Product name
17β-HydroxyExemestaneSulfamate
Packaging
10mg
Price
$2280
Updated
2021/12/16
AK Scientific
Product number
7621CS
Product name
MethyleneBoldenone,
Packaging
5mg
Price
$1043
Updated
2021/12/16
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Methylene boldenone Chemical Properties,Usage,Production

Description

17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = 0.43 and 1,500 nM for AR- and ER-mediated growth, respectively) and inhibits proliferation of testosterone-treated aromatase-overexpressing MCF-7aro cells in a concentration-dependent manner. 17β-hydroxy Exemestane (20 mg/kg) inhibits increases in serum cholesterol and LDL levels and prevents decreases in bone mineral density in the lumbar vertebrae and femur, as well as femoral bending strength and compressive strength of the fifth lumbar vertebrae, in ovariectomized rats.

Chemical Properties

Off-White Solid

Uses

A metabolite of Exemestane; exerts biological effects as an androgen.

Uses

17β-Hydroxy Exemestane Sulfamate is a metabolite of Exemestane (E957000).

Methylene boldenone Preparation Products And Raw materials

Raw materials

Preparation Products

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122370-91-6, Methylene boldenoneRelated Search:


  • METHYLENE BOLDENONE
  • (17b)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one
  • Exemestane 17β-Hydroxy Impurity
  • (17)-17-Hydroxy-6-methyleneandrosta-1,4-dien-3-one
  • 17--Hydroxy Exemestane
  • (17β)-
  • 17β-Hydroxy ExeMestane SulfaMate
  • Androsta-1,4-dien-3-one, 17-hydroxy-6-methylene-, (17β)-
  • 17β-Hydroxy Exemestane
  • (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-6-methylene-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • Exemestane Impurity 23 (Exemestane EP Impurity H)
  • 122370-91-6
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Steroids