ChemicalBook > CAS DataBase List > 4-N-Boc-aminocyclohexanone

4-N-Boc-aminocyclohexanone

Product Name: 4-N-Boc-aminocyclohexanone
CAS No.: 179321-49-4
Chemical Name: 4-N-Boc-aminocyclohexanone
Synonyms: N-4-BOC-AMINOCYCLOHEXANONE;TERT-BUTYL 4-OXOCYCLOHEXYLCARBAMATE;BOC-4-AMINOCYCLOHEXANONE;4-N-BOC-AMINOCYCLOHEXANONE;4-(Boc-Amino)cyclohexanone;N-Boc-4-Aminocyclohexanone;4-N-Boc-Aminocyclohexanone4;4-N-BOC-4-AMINOCYCLOHEXANONE;N-T-BOC-4-AMINOCYCLOHEXANONE;N-4-Boc-aminocyclohexanone 95%
CBNumber: CB2149316
Molecular Formula: C11H19NO3
Formula Weight: 213.27
MOL File: 179321-49-4.mol

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4-N-Boc-aminocyclohexanone Property

Melting point:: 114-118℃
Boiling point:: 335.9±31.0 °C(Predicted)
Density: 1.06±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: 12.19±0.20(Predicted)
color: White to Almost white
InChI: InChI=1S/C11H19NO3/c1-11(2,3)15-10(14)12-8-4-6-9(13)7-5-8/h8H,4-7H2,1-3H3,(H,12,14)
InChIKey: WYVFPGFWUKBXPZ-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1CCC(=O)CC1
CAS DataBase Reference: 179321-49-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N
Risk Statements: 36/37/38-50
Safety Statements: 26-36/37/39-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H400Very toxic to aquatic life
Precautionary statements: P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 750816
Product name: N-4-Boc-aminocyclohexanone
Purity: 95%
Packaging: 5g
Price: $67.6
Updated: 2025/07/31

TCI Chemical

Product number: B3856
Product name: 4-(tert-Butoxycarbonylamino)cyclohexanone
Purity: >98.0%(GC)
Packaging: 1g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: B3856
Product name: 4-(tert-Butoxycarbonylamino)cyclohexanone
Purity: >98.0%(GC)
Packaging: 5g
Price: $99
Updated: 2025/07/31

TRC

Product number: B617675
Product name: 4-(N-Boc-amino)cyclohexanone
Packaging: 10g
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: J20360
Product name: N-Boc-4-Aminocyclohexanone
Packaging: 5g
Price: $25
Updated: 2021/12/16

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4-N-Boc-aminocyclohexanone Chemical Properties,Usage,Production

Uses

4-N-Boc-aminocyclohexanone is a chemical that inhibits the proliferation of cancer cells in vitro. It also has an antiproliferative effect on fibroblast cells, which may be due to its ability to inhibit protein synthesis and induce cell death by apoptosis.It can also be used for the preparation of photoresponsive polymers that are used in drug delivery systems.

Synthesis

224309-64-2

179321-49-4

The general procedure for the synthesis of 4-N-Boc-aminocyclohexanone from 4-(Boc-amino)cyclohexanol was as follows: a dichloromethane solution of dimethyl sulfoxide (6 mL, containing 2.0 mL of dimethyl sulfoxide, 28.2 mmol) was added dropwise to a dichloromethane solution (30 mL) of oxalyl chloride (1.7 mL, 19.5 mmol) over a 10-minute period at -60°C. The dichloromethane solution was stirred for 10 minutes. After dropwise addition, stirring was continued at -60 °C for 10 min. Subsequently, tert-butyl 4-hydroxycyclohexylcarbamate (2.56 g, 11.9 mmol) was added dropwise to a dichloromethane solution (140 mL) over a period of 35 min and the reaction mixture was stirred at -60 °C for 40 min. Next, triethylamine (8.4 mL, 60.3 mmol) was added at -60 °C, after which the reaction mixture was allowed to warm up naturally to room temperature. After completion of the reaction, water was added to the mixture and extracted with chloroform. The organic layer was washed sequentially with saturated aqueous ammonium chloride solution and saturated aqueous sodium chloride solution, and then dried with magnesium sulfate. The solvent was removed by distillation under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: chloroform/ethyl acetate) to give tert-butyl 4-oxocyclohexylcarbamate (2.23 g, 87% yield).1H-NMR (DMSO-d6) data were as follows: 1.06-1.20 (4H, m), 1.35 (9H, s), 1.69-1.76 (4H, m). 3.12-3.31 (2H, m), 4.48 (1H, s), 6.64 (1H, d, J = 7.5 Hz).

References

[1] Patent: EP1403255, 2004, A1. Location in patent: Page 71
[2] Medicinal Chemistry Research, 2013, vol. 22, # 6, p. 2633 - 2644
[3] Patent: WO2015/22664, 2015, A1. Location in patent: Paragraph 00219;00220
[4] Patent: TW2017/36341, 2017, A. Location in patent: Paragraph 0489-0491
[5] Patent: WO2005/21515, 2005, A2. Location in patent: Page/Page column 72-73

4-N-Boc-aminocyclohexanone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-N-Boc-aminocyclohexanone manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-N-Boc-aminocyclohexanone 179321-49-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-25

Henan Aochuang Chemical Co.,Ltd.

Product: 4-N-Boc-aminocyclohexanone 179321-49-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-19

Shaanxi Dideu New Materials Co. Ltd

Product: 4-N-Boc-aminocyclohexanone 179321-49-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10000KGS
Release date: 2025-02-17

179321-49-4, 4-N-Boc-aminocyclohexanoneRelated Search:

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BOC-4-AMINOCYCLOHEXANONE

(4-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER

4-N-BOC-AMINOCYCLOHEXANONE

4-N-BOC-4-AMINOCYCLOHEXANONE

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N-4-BOC-AMINOCYCLOHEXANONE

N-T-BOC-4-AMINOCYCLOHEXANONE

TERT-BUTYL 4-OXOCYCLOHEXYLCARBAMATE

tert-Butyl (4-oxocyclohex-1-yl)carbamate, 1-[(tert-Butoxycarbonyl)amino]-4-oxocyclohexane

CarbaMic acid,N-(4-oxocyclohexyl)-, 1,1-diMethylethyl ester

N-4-Boc-aminocyclohexanone 95%

4-(Boc-Amino)cyclohexanone

Carbamic acid, (4-oxocyclohexyl)-, 1,1-dimethylethyl ester (9CI)

2-aMino-4-(3-chloro phenyl) thiazole

4-N-Boc-aMinocyclohexanone/tert-butyl 4-oxocyclohexylcarbaMate

4-AMinocyclohexanone N-tertbutyl ester

tert-butyl 4-oxocyclohexylcarbam

4-Aminocyclohexan-1-one, N-BOC protected

tert-Butyl (4-oxocyclohex-1-yl)carbamate, 1-Oxo-4-[(tert-butoxycarbonyl)amino]cyclohexane

tert-Butyl N-(4-oxocyclohexyl)carbaMate

4-(TERT-BUTOXYCARBONYLAMINO) CYCLOHEXANONE

4-N-Boc-Aminocyclohexanone4

N-Boc-4-Aminocyclohexanone

4-(tert-butyloxycarbonylamino)cyclohexanone

4-Aminocyclohexan-1-one, N-BOC protected 98%

4-(tert-Butoxycarbonylamino)cyclohexanone &gt

ert-butylN-(4-oxocyclohexyl)carbamate

4-N-Boc-aminocyclohexanone ISO 9001：2015 REACH

7-Piperazinecarboxamide,N,N-dimethyl-

N-4-Boc-aminocyclohexanone,98%

<i>N</i>-4-Boc-aminocyclohexanone

179321-49-4

885280-38-7

C11H19NO3

Acids and Derivatives

Carbonyl Compounds

pharmacetical

CHIRAL CHEMICALS

Building Blocks

C10 to C11

C11 to C12

Chemical Synthesis

Ethers

New Products for Chemical Synthesis

Nitrogen Compounds

Organic Building Blocks

Oxygen Compounds

N-BOC

Amines

blocks