1,6-NAPHTHYRIDINE, 4,7-DICHLORO-
- Product Name
- 1,6-NAPHTHYRIDINE, 4,7-DICHLORO-
- CAS No.
- 952138-13-5
- Chemical Name
- 1,6-NAPHTHYRIDINE, 4,7-DICHLORO-
- Synonyms
- 4,7-dichloro-1,6-naphthyridine;1,6-NAPHTHYRIDINE, 4,7-DICHLORO-
- CBNumber
- CB21502068
- Molecular Formula
- C8H4Cl2N2
- Formula Weight
- 199.04
- MOL File
- 952138-13-5.mol
1,6-NAPHTHYRIDINE, 4,7-DICHLORO- Property
- Boiling point:
- 324.9±37.0 °C(Predicted)
- Density
- 1.486±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.76±0.30(Predicted)
- Appearance
- White to light yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FD140877
- Product name
- 4,7-Dichloro-1,6-naphthyridine
- Packaging
- 100mg
- Price
- $94
- Updated
- 2021/12/16
- Product number
- OR932711
- Product name
- 4,7-Dichloro-1,6-naphthyridine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- 3H32-5-LH
- Product name
- 4,7-Dichloro-1,6-naphthyridine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $464
- Updated
- 2021/12/16
- Product number
- 144542
- Product name
- 4,7-Dichloro-1,6-naphthyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $496
- Updated
- 2021/12/16
- Product number
- HCH0361207
- Product name
- 4,7-DICHLORO-1,6-NAPHTHYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.51
- Updated
- 2021/12/16
1,6-NAPHTHYRIDINE, 4,7-DICHLORO- Chemical Properties,Usage,Production
Synthesis
952138-12-4
952138-13-5
7-Chloro-1,6-diazanaphthalen-4(1H)-one (340 mg, 1.89 mmol) was used as starting material and dissolved in 1,2-dichloroethane. Under stirring conditions, N,N-diisopropylethylamine (DIEA, 653 μL, 3.95 mmol) and phosphorochloridic acid (345 μL, 3.78 mmol) were added sequentially. The reaction mixture was stirred at 70 °C for 30 min. After completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water. The pH was adjusted to 8 with 2N NaOH solution and subsequently extracted with ethyl acetate (EA). The organic phase was washed with saturated ammonium chloride (NH4Cl) solution and dried with anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure and the resulting residue was purified by column chromatography to afford the target product 4,7-dichloro-1,6-naphthyridine in 94% yield. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 9.47 (d, J = 0.6 Hz, 1H), 9.10 (d, J = 4.7 Hz, 1H), 8.18 (s, 1H), 7.94 (dd, J = 4.8 Hz, 1H).
References
[1] Patent: US2018/244667, 2018, A1. Location in patent: Paragraph 0099
[2] Patent: WO2007/113565, 2007, A1. Location in patent: Page/Page column 97
1,6-NAPHTHYRIDINE, 4,7-DICHLORO- Preparation Products And Raw materials
Raw materials
Preparation Products
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