1,6-NAPHTHYRIDINE, 4,7-DICHLORO-

Product Name: 1,6-NAPHTHYRIDINE, 4,7-DICHLORO-
CAS No.: 952138-13-5
Chemical Name: 1,6-NAPHTHYRIDINE, 4,7-DICHLORO-
Synonyms: 4,7-dichloro-1,6-naphthyridine;1,6-NAPHTHYRIDINE, 4,7-DICHLORO-
CBNumber: CB21502068
Molecular Formula: C8H4Cl2N2
Formula Weight: 199.04
MOL File: 952138-13-5.mol

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1,6-NAPHTHYRIDINE, 4,7-DICHLORO- Property

Boiling point:: 324.9±37.0 °C(Predicted)
Density: 1.486±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.76±0.30(Predicted)
Appearance: White to light yellow Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FD140877
Product name: 4,7-Dichloro-1,6-naphthyridine
Packaging: 100mg
Price: $94
Updated: 2021/12/16

Apolloscientific

Product number: OR932711
Product name: 4,7-Dichloro-1,6-naphthyridine
Purity: 96%
Packaging: 250mg
Price: $290
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-LH
Product name: 4,7-Dichloro-1,6-naphthyridine
Purity: 96%
Packaging: 250mg
Price: $464
Updated: 2021/12/16

Matrix Scientific

Product number: 144542
Product name: 4,7-Dichloro-1,6-naphthyridine
Purity: 95%
Packaging: 1g
Price: $496
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0361207
Product name: 4,7-DICHLORO-1,6-NAPHTHYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $505.51
Updated: 2021/12/16

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1,6-NAPHTHYRIDINE, 4,7-DICHLORO- Chemical Properties,Usage,Production

Synthesis

952138-12-4

952138-13-5

7-Chloro-1,6-diazanaphthalen-4(1H)-one (340 mg, 1.89 mmol) was used as starting material and dissolved in 1,2-dichloroethane. Under stirring conditions, N,N-diisopropylethylamine (DIEA, 653 μL, 3.95 mmol) and phosphorochloridic acid (345 μL, 3.78 mmol) were added sequentially. The reaction mixture was stirred at 70 °C for 30 min. After completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water. The pH was adjusted to 8 with 2N NaOH solution and subsequently extracted with ethyl acetate (EA). The organic phase was washed with saturated ammonium chloride (NH4Cl) solution and dried with anhydrous sodium sulfate (Na2SO4). The solvent was removed by concentration under reduced pressure and the resulting residue was purified by column chromatography to afford the target product 4,7-dichloro-1,6-naphthyridine in 94% yield. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 9.47 (d, J = 0.6 Hz, 1H), 9.10 (d, J = 4.7 Hz, 1H), 8.18 (s, 1H), 7.94 (dd, J = 4.8 Hz, 1H).

References

[1] Patent: US2018/244667, 2018, A1. Location in patent: Paragraph 0099
[2] Patent: WO2007/113565, 2007, A1. Location in patent: Page/Page column 97

1,6-NAPHTHYRIDINE, 4,7-DICHLORO- Preparation Products And Raw materials

Raw materials

Preparation Products

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1,6-NAPHTHYRIDINE, 4,7-DICHLORO- Suppliers

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