TEMAFLOXACIN HYDROCHLORIDE

Product Name: TEMAFLOXACIN HYDROCHLORIDE
CAS No.: 105784-61-0
Chemical Name: TEMAFLOXACIN HYDROCHLORIDE
Synonyms: Abbott 62254;TEMAFLOXACIN HYDROCHLORIDE;1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-Quinolinecarboxylic acid hydrochloride;1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride;3-Quinolinecarboxylicacid,1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-,hydrochloride (1:1)
CBNumber: CB21504077
Molecular Formula: C21H18F3N3O3.ClH
Formula Weight: 453.846
MOL File: 105784-61-0.mol

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TEMAFLOXACIN HYDROCHLORIDE Property

storage temp.: Sealed in dry,Room Temperature
solubility: ≤2mg/ml in DMSO;5mg/ml in dimethyl formamide
form: crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17352
Product name: Temafloxacin (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $35
Updated: 2021/12/16

Cayman Chemical

Product number: 17352
Product name: Temafloxacin (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $96
Updated: 2021/12/16

Cayman Chemical

Product number: 17352
Product name: Temafloxacin (hydrochloride)
Purity: ≥95%
Packaging: 25mg
Price: $263
Updated: 2021/12/16

Cayman Chemical

Product number: 17352
Product name: Temafloxacin (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $158
Updated: 2021/12/16

TRC

Product number: T017190
Product name: TemafloxacinHydrochloride
Packaging: 25mg
Price: $265
Updated: 2021/12/16

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TEMAFLOXACIN HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Temafloxacin hydrochloride is a new fluoroquinolone antibacterial structurally and mechanistically related to tosufloxacin, another microbial DNA topoisomerase inhibitor introduced in 1990. It is particularly useful against beta-lactamase producing organisms and is indicated for the treatment of respiratory and urinary tract infections as well as sexually transmitted diseases, skin and soft tissue infections. The compound has high tissue penetration and is reported to have a low propensity to cause adverse effects and drug interactions.

Originator

Abbott (U.S.A.)

Uses

Temafloxacin Hydrochloride is an antimicrobial quinolone drug.

Uses

Antibacterial (microbial DNA topoisomerase inhibitor).

brand name

Omniflox (Abbott);Temac.

in vitro

the in-vitro activities of temafloxacin, ciprofloxacin, and ofloxacin against gram-negative bacteria were compared. the 90% minimal inhibitory concentrations (mic90s) of temafloxacin for respiratory pathogens were less than or equal to 0.06 micrograms/ml. temafloxacin was also active against bacterial agents of sexually transmitted diseases, such as neisseria gonorrhoeae and chlamydia trachomatis [1].

in vivo

mixed aerobic-anaerobic infection was induced by i.p. implantation of gelatin capsules containing bacteroides fragilis, escherichia coli, and sterile rat faeces. temafloxacin was found to be highly active with a 90.9% cure rate in comparison with no treatment, and as active as a combination of clindamycin and gentamicin. temafloxacin at 12 mg/dose resulted in rise to serum concentrations exceeding the mic values of both microorganisms for at least 8 h [2].

References

[1] hardy dj. in vitro activity of temafloxacin against gram-negative bacteria: an overview. am j med. 1991 dec 30;91(6a):19s-23s.
[2] thadepalli h, hajji m, perumal vk, chuah sk, gollapudi s. evaluation of temafloxacin in a rat model of intra-abdominal abscess. j antimicrob chemother. 1992 jun;29(6):687-92.
[3] ball p. the role of temafloxacin in the community setting: an overview. j antimicrob chemother. 1991 dec;28 suppl c:121-30.

TEMAFLOXACIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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105784-61-0, TEMAFLOXACIN HYDROCHLORIDERelated Search:

Sarafloxacin 2-FLUORODIPHENYLAMINE TEMAFLOXACIN HYDROCHLORIDE 1-(2-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE Sarafloxacin hydrochloride 4-FLUORODIPHENYLAMINE TEMAFLOXACIN

TEMAFLOXACIN HYDROCHLORIDE

1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-Quinolinecarboxylic acid hydrochloride

Abbott 62254

3-Quinolinecarboxylicacid,1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-,hydrochloride (1:1)

1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride

105784-61-0

C21H18F3N3O3HCl

C21H18F3N3O3ClH