[1,5]-NAPHTHYRIDIN-2-YLAMINE

Product Name: [1,5]-NAPHTHYRIDIN-2-YLAMINE
CAS No.: 17965-80-9
Chemical Name: [1,5]-NAPHTHYRIDIN-2-YLAMINE
Synonyms: 2-Amino-1,5-naphthyridin;1,5-naphthyridin-2-amine;[1,5]-NAPHTHYRIDIN-2-YLAMINE
CBNumber: CB2150417
Molecular Formula: C8H7N3
Formula Weight: 145.16
MOL File: 17965-80-9.mol

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[1,5]-NAPHTHYRIDIN-2-YLAMINE Property

Melting point:: 204-205 °C
Boiling point:: 322.6±22.0 °C(Predicted)
Density: 1.292±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 4.98±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: N373533
Product name: [1,5]-Naphthyridin-2-ylamine
Packaging: 50mg
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: W9919
Product name: 1,5-Naphthyridin-2-ylamine
Packaging: 250mg
Price: $204
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0016339
Product name: [1,5]-NAPHTHYRIDIN-2-YLAMINE
Purity: 95.00%
Packaging: 10G
Price: $1673.6
Updated: 2021/12/16

Ambeed

Product number: A468022
Product name: 1,5-Naphthyridin-2-amine
Purity: 98%
Packaging: 100mg
Price: $80
Updated: 2021/12/16

Ambeed

Product number: A468022
Product name: 1,5-Naphthyridin-2-amine
Purity: 98%
Packaging: 250mg
Price: $124
Updated: 2021/12/16

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[1,5]-NAPHTHYRIDIN-2-YLAMINE Chemical Properties,Usage,Production

Synthesis

4318-76-7

56-81-5

17965-80-9

Using 2,5-diaminopyridine (5.2 g, 33.9 mmol) and glycerol (15.6 g, 169.5 mmol) as raw materials, sodium 3-nitrobenzenesulfonate (15.2 g, 67.8 mmol) and sulfuric acid (20 mL) were added in water (30 mL), and the mixture was heated to 135 °C and reacted with stirring for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently slowly poured into an ice-water mixture (150 g). The pH of the mixture was adjusted to neutral with an appropriate base. Subsequently, the reaction mixture was extracted with ethyl acetate (3 x 100 mL), the organic layers were combined and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography using dichloromethane/methanol (20:1, v/v) as eluent to afford 1,5-naphthyridin-2-amine as a yellow solid (2.0 g, 41% yield). The product was analyzed by ESI MS showing m/z 146 [M + H]+. 1H NMR (400 MHz, DMSO-d6) data were as follows: δ 8.50 (dd, J = 1.6 Hz, 4.4 Hz, 1H), 7.94 (d, J = 8.8 Hz, 1H), 7.82-7.80 (m, 1H), 7.47 (dd, J = 4.0 Hz 8.4 Hz, 1H), 7.00 (d, J = 9.2 Hz, 1H), 6.72 (s, 2H).

References

[1] Patent: US2012/178748, 2012, A1. Location in patent: Page/Page column 47
[2] Yakugaku Zasshi, 1942, vol. 62, p. 257,265; dtsch. Ref. S. 66
[3] Chem.Abstr., 1951, p. 2950
[4] Patent: WO2011/150156, 2011, A2. Location in patent: Page/Page column 133

[1,5]-NAPHTHYRIDIN-2-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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[1,5]-NAPHTHYRIDIN-2-YLAMINE Suppliers

China 39 Germany 1 India 2 United Kingdom 1 United States 8 Global 51

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View Lastest Price from [1,5]-NAPHTHYRIDIN-2-YLAMINE manufacturers

Career Henan Chemical Co

Product: [1,5]-NAPHTHYRIDIN-2-YLAMINE 17965-80-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-12-18

17965-80-9, [1,5]-NAPHTHYRIDIN-2-YLAMINERelated Search:

2-[(6,7-dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)carbonyl]-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridin-3-ylamine [1,6]NAPHTHYRIDIN-2-YLAMINE [1,6]NAPHTHYRIDIN-4-YLAMINE HYDROCHLORIDE 7-METHYL-[1,8]NAPHTHYRIDIN-2-YLAMINE 2,4-BIS(TRIFLUOROMETHYL)[1,2,4]TRIAZOLO[4,3-A][1,8]NAPHTHYRIDIN-9-YLAMINE 1,5-NAPHTHYRIDIN-4-YLAMINE [1,6]NAPHTHYRIDIN-4-YLAMINE 5-BROMO-[1,7]NAPHTHYRIDIN-8-YLAMINE 5,7-bis(trifluoromethyl)[1,8]naphthyridin-2-ylamine [2,7]NAPHTHYRIDIN-1-YLAMINE [1,5]-NAPHTHYRIDIN-2-YLAMINE 1,5-NAPHTHYRIDINE

[1,5]-NAPHTHYRIDIN-2-YLAMINE

1,5-naphthyridin-2-amine

2-Amino-1,5-naphthyridin

17965-80-9