1,5-NAPHTHYRIDINE

Product Name: 1,5-NAPHTHYRIDINE
CAS No.: 254-79-5
Chemical Name: 1,5-NAPHTHYRIDINE
Synonyms: 1,5-DIAZANAPHTHALENE;1,5phthyridine;1, 5 - nalidixic;1,5-NAPHTHYRIDINE;1,5-Pyridopyridine;1,5-Naphthyridine>Pyrido[3,2-b]pyridine;PYRIDO[1,5-B]PYRIDINE;1,5-Naphthyridine 97%;1,5-Naphthyridine, 97+%
CBNumber: CB1313088
Molecular Formula: C8H6N2
Formula Weight: 130.15
MOL File: 254-79-5.mol

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1,5-NAPHTHYRIDINE Property

Melting point:: 69-75 °C
Boiling point:: 152 °C / 54mmHg
Density: 1.25
refractive index: 1.6231 (estimate)
storage temp.: Sealed in dry,Room Temperature
pka: 2.90±0.10(Predicted)
form: Solid
color: Off-white
InChI: InChI=1S/C8H6N2/c1-3-7-8(9-5-1)4-2-6-10-7/h1-6H
InChIKey: VMLKTERJLVWEJJ-UHFFFAOYSA-N
SMILES: N1C2C(=NC=CC=2)C=CC=1
CAS DataBase Reference: 254-79-5(CAS DataBase Reference)
NIST Chemistry Reference: 1,5-Naphthyridine(254-79-5)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36/37/39-39
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 673218
Product name: 1,5-Naphthyridine
Purity: 96%
Packaging: 1g
Price: $68
Updated: 2025/07/31

TCI Chemical

Product number: N0401
Product name: 1,5-Naphthyridine
Purity: >98.0%(T)
Packaging: 100mg
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: N0401
Product name: 1,5-Naphthyridine
Purity: >98.0%(T)
Packaging: 1g
Price: $114
Updated: 2025/07/31

TRC

Product number: N325013
Product name: 1,5-Naphthyridine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H44-1-10
Product name: 1,5-Naphthyridine
Packaging: 5G
Price: $114
Updated: 2021/12/16

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1,5-NAPHTHYRIDINE Chemical Properties,Usage,Production

Chemical Properties

off-whtie solid

Definition

ChEBI: 1,5-naphthyridine is a naphthyridine.

Synthesis

462-08-8

56-81-5

254-79-5

Synthesis of 1,5-naphthyridine (4): To a round bottom flask was added 3-aminopyridine (1 g, 10.63 mmol), sodium m-nitrobenzenesulfonate (3.59 g, 15.95 mmol), glycerol (3.33 mL, 46.85 mmol), concentrated sulfuric acid (5.92 mL, 111.53 mmol) and water (3 mL). The reaction mixture was heated to 150 °C and stirred continuously for 2.5 hours. Upon completion of the reaction, it was cooled to room temperature and the pH was adjusted to 8 with 4 M sodium hydroxide solution, followed by extraction with ethyl acetate (5 x 30 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by column chromatography (petroleum ether/ethyl acetate=1:1) afforded the target product 1,5-naphthyridine (622 mg, 45% yield) as a yellow solid. Melting point: 74~75°C (literature value 75°C). 1H NMR (400MHz, CDCl3): δ9.04-8.96 (m, 2H), 8.43 (d, J=8.4Hz, 2H), 7.66 (dd, J=8.4,4.1Hz, 2H).

Purification Methods

Purify 1,5-naphthyridine by repeated sublimation. The picrate crystallises from EtOH with m 200o(dec). [UV: Armarego Physical Methods in Heterocyclic Chemistry (Ed Katritzky, Academic Press) Vol III 133 1971, Beilstein 23 II 178, 23 III/IV 1235.]

References

[1] Synthetic Communications, 2011, vol. 41, # 12, p. 1843 - 1851
[2] Tetrahedron Letters, 2002, vol. 43, # 20, p. 3747 - 3750
[3] Organic Letters, 2000, vol. 2, # 7, p. 875 - 878
[4] Chemistry - A European Journal, 2017, vol. 23, # 53, p. 13046 - 13050
[5] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 16, p. 3251 - 3255

1,5-NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,5-NAPHTHYRIDINE Suppliers

Americas 1 China 162 Europe 2 Germany 4 India 5 Japan 2 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 3 United Kingdom 4 United States 22 Global 209

Carbott PharmTech Inc.

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Energy Chemical

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Beijing Ouhe Technology Co., Ltd

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Jia Xing Isenchem Co.,Ltd

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Pure Chemistry Scientific Inc.

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View Lastest Price from 1,5-NAPHTHYRIDINE manufacturers

Dideu Industries Group Limited

Product: 1,5-NAPHTHYRIDINE 254-79-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,5-NAPHTHYRIDINE 254-79-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 1,5-NAPHTHYRIDINE 254-79-5
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: customise
Release date: 2018-08-09

254-79-5, 1,5-NAPHTHYRIDINERelated Search:

5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDIN-3-OL 1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro- 2,7-NAPHTHYRIDINE, 1-CHLORO- 6-benzyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one 4-HYDROXY-1,5-NAPHTHYRIDINE-3-CARBOXYLIC ACID APALCILLIN 1,5-NAPHTHYRIDINE 1,5-NAPHTHYRIDIN-4-AMINE 4-HYDROXY-[1,5]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 7,10-dichloro-2-methoxybenzo[b]-1,5-naphthyridine [1,5]-NAPHTHYRIDIN-2-YLAMINE Pyronaridine 4-HYDROXY-1,5-NAPHTHYRIDINE 2-Bromo-1,5-naphthyridine 5-chloro-1,2,3,4-tetrahydro-1,6-naphthyridine 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Aspoxicillin

1,5-NAPHTHYRIDINE

1,5-DIAZANAPHTHALENE

PYRIDO[1,5-B]PYRIDINE

1,5-Pyridopyridine

1,5-Naphthyridine(6CI,8CI,9CI)

Pyrido[3,2-b]pyridine

1,5phthyridine

1,5-Diazanaphthalene Pyrido[1,5-b]pyridine

1,5-Naphthyridine, 97+%

1,5-Naphthyridine&gt

1, 5 - nalidixic

1,5-NAPHTHYRIDINE ISO 9001：2015 REACH

1,5-Naphthyridine 97%

254-79-5

245-79-5

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