4-Hydroxy-1,5-naphthyridine
Uses- Product Name
- 4-Hydroxy-1,5-naphthyridine
- CAS No.
- 5423-54-1
- Chemical Name
- 4-Hydroxy-1,5-naphthyridine
- Synonyms
- 1,5phthyridin-4-ol;[1,5]NAPHTHYRIDIN-4-OL;8-Hydroxy-1,5-naphthyridine;4-HYDROXY-1,5-NAPHTHYRIDINE;4-Hydroxy-1,5-naphthyridine?New;Benzoicacid,3-bromo-,1,6-dimethylethylester;1H-Imidazole-4-carboxylicacid,1-(8-bromophenyl)-
- CBNumber
- CB6279246
- Molecular Formula
- C8H6N2O
- Formula Weight
- 146.15
- MOL File
- 5423-54-1.mol
4-Hydroxy-1,5-naphthyridine Property
- Melting point:
- 340 °C (sublm)
- Boiling point:
- 332.7±22.0 °C(Predicted)
- Density
- 1.347±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.37±0.40(Predicted)
- Appearance
- Off-white to gray Solid
- InChI
- InChI=1S/C8H6N2O/c11-7-3-5-9-6-2-1-4-10-8(6)7/h1-5H,(H,9,11)
- InChIKey
- NSPLFNGUPLZYHV-UHFFFAOYSA-N
- SMILES
- N1C2C(=NC=CC=2)C(O)=CC=1
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- B504318
- Product name
- 1,5-Naphthyridin-4-ol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR951046
- Product name
- 4-Hydroxy-1,5-naphthyridine
- Purity
- 95%
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 076465
- Product name
- 4-Hydroxy-1,5-naphthyridine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $118
- Updated
- 2021/12/16
- Product number
- OR951046
- Product name
- 4-Hydroxy-1,5-naphthyridine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 076465
- Product name
- 4-Hydroxy-1,5-naphthyridine
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $153
- Updated
- 2021/12/16
4-Hydroxy-1,5-naphthyridine Chemical Properties,Usage,Production
Uses
4-Hydroxy-1,5-Naphthidine is a heterocyclic derivative that can be used as an intermediate in organic synthesis.
Synthesis
25063-68-7
5423-54-1
General procedure for the synthesis of 4-hydroxy-1,5-naphthyridine (ZS96) from 2,2-dimethyl-5-((pyridin-3-ylamino)methylene)-1,3-dioxane-4,6-dione: ZS95 (100 mg, 0.403 mmol) was dissolved in diphenyl ether (3.0 mL) and refluxed for 50 min on a Bunsen burner. After completion of the reaction, the mixture was cooled to room temperature, the precipitate was collected by filtration and washed with hexane. The crude product was dried and purified by sublimation at 210 °C and 20 mbar to give white crystals ZS96 (40 mg, 68% yield).ZS96 sublimated slowly over 200 °C. IR (ATR, cm-1): 3012 (m), 2925 (s), 2855 (s), 2077 (w), 1975 (w), 1623 ( s), 1583 (m), 1559 (m), 1502 (s), 1461 (m), 1421 (m), 1328 (w), 1192 (w), 1137 (w), 1073 (w), 977 (w), 885 (w), 818 (w), 779 (w), 724 (w), 682 (w), 590 (w), 546 (w) , 481 (w).1H NMR (500 MHz, CDCl3 + d-TFA, δ): 9.15 (dd, J = 8.8, 1.2 Hz, 1H), 9.12-9.10 (m, 1H), 8.51 (d, J = 7.4 Hz, 1H), 8.41 (dd, J = 8.9, 5.4 Hz, 1H), 7.19 (d, J = 7.4 Hz, 1H). 13C NMR (125 MHz, CDCl3 + d-TFA, δ): 173.25, 147.30, 144.98, 142.03, 131.98, 131.43, 121.01, 116.06. HRMS: m/z 147.05496 [M+H]+, corresponds to molecular formula C8H6N2O (calculation error: -2.22 ppm).
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 4, p. 1343 - 1361
[2] European Journal of Medicinal Chemistry, 2019, p. 32 - 50
4-Hydroxy-1,5-naphthyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-Hydroxy-1,5-naphthyridine Suppliers
- Tel
- 13933818572
- Fax
- 0311-82870388
- 1519554262@qq.com
- Country
- China
- ProdList
- 1785
- Advantage
- 58
- Tel
- 21-57721279
- Fax
- QQ：14057904
- sales@shydchem.com.cn
- Country
- China
- ProdList
- 998
- Advantage
- 56
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- +86-021-37788663
- Fax
- +86-021-37788663
- Country
- China
- ProdList
- 186
- Advantage
- 64
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- 021-54540637 18621091017
- Fax
- 021-34978309
- sales@amaspharm.com
- Country
- China
- ProdList
- 781
- Advantage
- 62
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- +86 (21) 5196-9732
- Fax
- +86 (21) 5196-9733
- Country
- China
- ProdList
- 996
- Advantage
- 57
- Tel
- 0370-2785118 17550508557
- Fax
- QQ：3470079902
- 675141927@qq.com
- Country
- China
- ProdList
- 3199
- Advantage
- 55
- Tel
- 22-58627059 13920586291
- Fax
- 022-58620305
- zdcomcon@126.com
- Country
- China
- ProdList
- 3829
- Advantage
- 50
View Lastest Price from 4-Hydroxy-1,5-naphthyridine manufacturers
- Product
- 4-Hydroxy-1,5-naphthyridine 5423-54-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09