1,6-NAPHTHYRIDINE
Uses- Product Name
- 1,6-NAPHTHYRIDINE
- CAS No.
- 253-72-5
- Chemical Name
- 1,6-NAPHTHYRIDINE
- Synonyms
- Naphthyridine;6-Naphthyridine;1,6-PHTHYRIDINE;1,6-naphthhydrine;1,6-NAPHTHYRIDINE;1,6-Pyridopyridine;1,6-Naphthylridine;1,6-DIAZANAPHTHALENE;PYRIDO[4,3-B]PYRIDINE;1,6-NAPHTHYRIDINE 96+%
- CBNumber
- CB8404040
- Molecular Formula
- C8H6N2
- Formula Weight
- 130.15
- MOL File
- 253-72-5.mol
1,6-NAPHTHYRIDINE Property
- Melting point:
- 231-233°C
- Boiling point:
- 267.3±13.0 °C(Predicted)
- Density
- 1.183±0.06 g/cm3(Predicted)
- Flash point:
- 35 °C
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 3.70±0.10(Predicted)
- color
- White to Light yellow
- CAS DataBase Reference
- 253-72-5(CAS DataBase Reference)
- EPA Substance Registry System
- 1,6-Naphthyridine (253-72-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000839
- Product name
- [1,6]Naphthyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $463
- Updated
- 2023/01/07
- Product number
- N0462
- Product name
- 1,6-Naphthyridine
- Purity
- >97.0%(T)
- Packaging
- 100mg
- Price
- $49
- Updated
- 2025/07/31
- Product number
- N0462
- Product name
- 1,6-Naphthyridine
- Purity
- >97.0%(T)
- Packaging
- 1g
- Price
- $291
- Updated
- 2025/07/31
- Product number
- W4869
- Product name
- 1,6-Naphthyridine
- Packaging
- 500mg
- Price
- $299
- Updated
- 2021/12/16
- Product number
- 3H32-1-29
- Product name
- [1,6]Naphthyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $376
- Updated
- 2021/12/16
1,6-NAPHTHYRIDINE Chemical Properties,Usage,Production
Uses
1,5-Diazonaphthalene is a pharmaceutical intermediate that can be prepared from 4-aminopyridine as a starting material and can be used to prepare CXCR4 inhibitors.
Definition
ChEBI: 1,6-naphthyridine is a naphthyridine.
Synthesis
504-24-5
107-21-1
253-72-5
The general procedure for the synthesis of 1,6-naphthyridine from 4-aminopyridine and ethylene glycol was as follows: first, a sulfuric acid solution was prepared by slowly adding 100 mL of concentrated sulfuric acid to 57 mL of water cooled in an ice bath. Subsequently, 33 mL of glycerol (457 mmol), 48 g of m-nitrobenzenesulfonic acid sodium salt (212 mmol), and 10 g of 4-aminopyridine (106 mmol) were sequentially added to this solution. The reaction mixture was heated to reflux at 135 °C for 4 hours. Upon completion of the reaction, the cooled reaction mixture was alkalized with 500 mL of 2.5 N sodium hydroxide solution and cooled in an ice bath. Subsequently, extraction was performed with dichloromethane (3 x 200 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give an oil. The oily substance was purified by column chromatography (5% methanol/dichloromethane as eluent) to give 5.04 g (36% yield) of dark orange oily product. For the preparation of analytical samples, the product was converted to HCl salt and recrystallized from ethyl acetate to give an orange low melting point solid. Mass spectrometry analysis showed a molecular ion peak m/z 130 (M+). Ref: Chem Pharm Bull. 1971, 19, 9, 1751-1755.
References
[1] Patent: EP1147083, 2004, B1. Location in patent: Page 47
1,6-NAPHTHYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,6-NAPHTHYRIDINE manufacturers
- Product
- 1,6-NAPHTHYRIDINE 253-72-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
- Product
- 1,6-naphthyridine 253-72-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-02-14