ChemicalBook > CAS DataBase List > 1,6-NAPHTHYRIDINE

1,6-NAPHTHYRIDINE

Uses

Product Name: 1,6-NAPHTHYRIDINE
CAS No.: 253-72-5
Chemical Name: 1,6-NAPHTHYRIDINE
Synonyms: Naphthyridine;6-Naphthyridine;1,6-PHTHYRIDINE;1,6-naphthhydrine;1,6-NAPHTHYRIDINE;1,6-Pyridopyridine;1,6-Naphthylridine;1,6-DIAZANAPHTHALENE;PYRIDO[4,3-B]PYRIDINE;1,6-NAPHTHYRIDINE 96+%
CBNumber: CB8404040
Molecular Formula: C8H6N2
Formula Weight: 130.15
MOL File: 253-72-5.mol

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1,6-NAPHTHYRIDINE Property

Melting point:: 231-233°C
Boiling point:: 267.3±13.0 °C(Predicted)
Density: 1.183±0.06 g/cm3(Predicted)
Flash point:: 35 °C
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 3.70±0.10(Predicted)
color: White to Light yellow
CAS DataBase Reference: 253-72-5(CAS DataBase Reference)
EPA Substance Registry System: 1,6-Naphthyridine (253-72-5)

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Safety

Hazard Codes: Xi
Risk Statements: 41
Safety Statements: 26-39
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000839
Product name: [1,6]Naphthyridine
Purity: Aldrich
Packaging: 1g
Price: $463
Updated: 2023/01/07

TCI Chemical

Product number: N0462
Product name: 1,6-Naphthyridine
Purity: >97.0%(T)
Packaging: 100mg
Price: $49
Updated: 2025/07/31

TCI Chemical

Product number: N0462
Product name: 1,6-Naphthyridine
Purity: >97.0%(T)
Packaging: 1g
Price: $291
Updated: 2025/07/31

Matrix Scientific

Product number: 021364
Product name: [1,6]Naphthyridine
Purity: 98%
Packaging: 250mg
Price: $74
Updated: 2021/12/16

AK Scientific

Product number: W4869
Product name: 1,6-Naphthyridine
Packaging: 250mg
Price: $149
Updated: 2021/12/16

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1,6-NAPHTHYRIDINE Chemical Properties,Usage,Production

Uses

1,5-Diazonaphthalene is a pharmaceutical intermediate that can be prepared from 4-aminopyridine as a starting material and can be used to prepare CXCR4 inhibitors.

Definition

ChEBI: 1,6-naphthyridine is a naphthyridine.

Synthesis

504-24-5

107-21-1

253-72-5

The general procedure for the synthesis of 1,6-naphthyridine from 4-aminopyridine and ethylene glycol was as follows: first, a sulfuric acid solution was prepared by slowly adding 100 mL of concentrated sulfuric acid to 57 mL of water cooled in an ice bath. Subsequently, 33 mL of glycerol (457 mmol), 48 g of m-nitrobenzenesulfonic acid sodium salt (212 mmol), and 10 g of 4-aminopyridine (106 mmol) were sequentially added to this solution. The reaction mixture was heated to reflux at 135 °C for 4 hours. Upon completion of the reaction, the cooled reaction mixture was alkalized with 500 mL of 2.5 N sodium hydroxide solution and cooled in an ice bath. Subsequently, extraction was performed with dichloromethane (3 x 200 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give an oil. The oily substance was purified by column chromatography (5% methanol/dichloromethane as eluent) to give 5.04 g (36% yield) of dark orange oily product. For the preparation of analytical samples, the product was converted to HCl salt and recrystallized from ethyl acetate to give an orange low melting point solid. Mass spectrometry analysis showed a molecular ion peak m/z 130 (M+). Ref: Chem Pharm Bull. 1971, 19, 9, 1751-1755.

References

[1] Patent: EP1147083, 2004, B1. Location in patent: Page 47

1,6-NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,6-NAPHTHYRIDINE manufacturers

Dideu Industries Group Limited

Product: 1,6-NAPHTHYRIDINE 253-72-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-26

Career Henan Chemical Co

Product: 1,6-naphthyridine 253-72-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons
Release date: 2020-02-14

253-72-5, 1,6-NAPHTHYRIDINERelated Search:

3-BROMO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE 3-(CHLOROMETHYL)-6-(TRIFLUOROMETHYL)PYRIDINE 4-HYDROXY-[1,5]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Nalidixic acid 4-HYDROXY-1,5-NAPHTHYRIDINE 4-HYDROXY-1,5-NAPHTHYRIDINE-3-CARBOXYLIC ACID 1,6-NAPHTHYRIDINE 3-ACETYL-2-METHYL-1,6-NAPHTHYRIDINE 2-METHYL-1,6-NAPHTHYRIDINE-3-CARBOXYLATE, ETHYL ESTER 2-(TRIFLUOROMETHYL)-1,6-NAPHTHYRIDINE-3-CARBOXYLIC ACID 2-(DIMETHOXYMETHYL)-1,6-NAPHTHYRIDINE 1,6-NAPHTHYRIDINE-2-CARBOXYLIC ACID 1,2,3,4-TETRAHYDRO-1,5-NAPHTHYRIDINE 2-(TRIFLUOROMETHYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID METHYL1,6-NAPHTHYRIDINE-2-CARBOXYLATE 4-HYDROXY-[1,6]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 4-CHLORO-1,5-NAPHTHYRIDINE 4-CHLORO-[1,8]NAPHTHYRIDINE

1,6-DIAZANAPHTHALENE

1,6-NAPHTHYRIDINE

1,6-Naphthyridine(6CI,7CI,8CI,9CI)

1,6-Pyridopyridine

PYRIDO[4,3-B]PYRIDINE

Naphthyridine

1,6-NAPHTHYRIDINE 96+%

6-Naphthyridine

1,6-naphthhydrine

1,6-Diazanaphthalene Pyrido[4,3-b]pyridine

Substituted naphthyridine derivative

1,6-PHTHYRIDINE

1,6-Naphthylridine

1,6-NAPHTHYRIDINE ISO 9001：2015 REACH

253-72-5

C8H6N2

PYRIDINE

Heterocycle-Pyridine series