ChemicalBook > CAS DataBase List > 4-Hydroxy-1,5-naphthyridine

4-Hydroxy-1,5-naphthyridine

Uses

Product Name: 4-Hydroxy-1,5-naphthyridine
CAS No.: 5423-54-1
Chemical Name: 4-Hydroxy-1,5-naphthyridine
Synonyms: 1,5phthyridin-4-ol;[1,5]NAPHTHYRIDIN-4-OL;8-Hydroxy-1,5-naphthyridine;4-HYDROXY-1,5-NAPHTHYRIDINE;4-Hydroxy-1,5-naphthyridine?New;Benzoicacid,3-bromo-,1,6-dimethylethylester;1H-Imidazole-4-carboxylicacid,1-(8-bromophenyl)-
CBNumber: CB6279246
Molecular Formula: C8H6N2O
Formula Weight: 146.15
MOL File: 5423-54-1.mol

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4-Hydroxy-1,5-naphthyridine Property

Melting point:: 340 °C (sublm)
Boiling point:: 332.7±22.0 °C(Predicted)
Density: 1.347±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 3.37±0.40(Predicted)
Appearance: Off-white to gray Solid
InChI: InChI=1S/C8H6N2O/c11-7-3-5-9-6-2-1-4-10-8(6)7/h1-5H,(H,9,11)
InChIKey: NSPLFNGUPLZYHV-UHFFFAOYSA-N
SMILES: N1C2C(=NC=CC=2)C(O)=CC=1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: B504318
Product name: 1,5-Naphthyridin-4-ol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR951046
Product name: 4-Hydroxy-1,5-naphthyridine
Purity: 95%
Packaging: 100mg
Price: $100
Updated: 2021/12/16

Matrix Scientific

Product number: 076465
Product name: 4-Hydroxy-1,5-naphthyridine
Purity: 95+%
Packaging: 250mg
Price: $118
Updated: 2021/12/16

Apolloscientific

Product number: OR951046
Product name: 4-Hydroxy-1,5-naphthyridine
Purity: 95%
Packaging: 250mg
Price: $150
Updated: 2021/12/16

Matrix Scientific

Product number: 076465
Product name: 4-Hydroxy-1,5-naphthyridine
Purity: 95+%
Packaging: 500mg
Price: $153
Updated: 2021/12/16

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4-Hydroxy-1,5-naphthyridine Chemical Properties,Usage,Production

Uses

4-Hydroxy-1,5-Naphthidine is a heterocyclic derivative that can be used as an intermediate in organic synthesis.

Synthesis

25063-68-7

5423-54-1

General procedure for the synthesis of 4-hydroxy-1,5-naphthyridine (ZS96) from 2,2-dimethyl-5-((pyridin-3-ylamino)methylene)-1,3-dioxane-4,6-dione: ZS95 (100 mg, 0.403 mmol) was dissolved in diphenyl ether (3.0 mL) and refluxed for 50 min on a Bunsen burner. After completion of the reaction, the mixture was cooled to room temperature, the precipitate was collected by filtration and washed with hexane. The crude product was dried and purified by sublimation at 210 °C and 20 mbar to give white crystals ZS96 (40 mg, 68% yield).ZS96 sublimated slowly over 200 °C. IR (ATR, cm-1): 3012 (m), 2925 (s), 2855 (s), 2077 (w), 1975 (w), 1623 ( s), 1583 (m), 1559 (m), 1502 (s), 1461 (m), 1421 (m), 1328 (w), 1192 (w), 1137 (w), 1073 (w), 977 (w), 885 (w), 818 (w), 779 (w), 724 (w), 682 (w), 590 (w), 546 (w) , 481 (w).1H NMR (500 MHz, CDCl3 + d-TFA, δ): 9.15 (dd, J = 8.8, 1.2 Hz, 1H), 9.12-9.10 (m, 1H), 8.51 (d, J = 7.4 Hz, 1H), 8.41 (dd, J = 8.9, 5.4 Hz, 1H), 7.19 (d, J = 7.4 Hz, 1H). 13C NMR (125 MHz, CDCl3 + d-TFA, δ): 173.25, 147.30, 144.98, 142.03, 131.98, 131.43, 121.01, 116.06. HRMS: m/z 147.05496 [M+H]+, corresponds to molecular formula C8H6N2O (calculation error: -2.22 ppm).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 4, p. 1343 - 1361
[2] European Journal of Medicinal Chemistry, 2019, p. 32 - 50

4-Hydroxy-1,5-naphthyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Hydroxy-1,5-naphthyridine manufacturers

Career Henan Chemical Co

Product: 4-Hydroxy-1,5-naphthyridine 5423-54-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

5423-54-1, 4-Hydroxy-1,5-naphthyridineRelated Search:

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4-HYDROXY-1,5-NAPHTHYRIDINE

8-Hydroxy-1,5-naphthyridine

1,5phthyridin-4-ol

1H-Imidazole-4-carboxylicacid,1-(8-bromophenyl)-

Benzoicacid,3-bromo-,1,6-dimethylethylester

4-Hydroxy-1,5-naphthyridine?New

5423-54-1

Heterocycle-Pyridine series