Uses
ChemicalBook > CAS DataBase List > 4-Hydroxy-1,5-naphthyridine

4-Hydroxy-1,5-naphthyridine

Uses
Product Name
4-Hydroxy-1,5-naphthyridine
CAS No.
5423-54-1
Chemical Name
4-Hydroxy-1,5-naphthyridine
Synonyms
1,5phthyridin-4-ol;[1,5]NAPHTHYRIDIN-4-OL;8-Hydroxy-1,5-naphthyridine;4-HYDROXY-1,5-NAPHTHYRIDINE;4-Hydroxy-1,5-naphthyridine?New;Benzoicacid,3-bromo-,1,6-dimethylethylester;1H-Imidazole-4-carboxylicacid,1-(8-bromophenyl)-
CBNumber
CB6279246
Molecular Formula
C8H6N2O
Formula Weight
146.15
MOL File
5423-54-1.mol
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4-Hydroxy-1,5-naphthyridine Property

Melting point:
340 °C (sublm)
Boiling point:
332.7±22.0 °C(Predicted)
Density 
1.347±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
3.37±0.40(Predicted)
Appearance
Off-white to gray Solid
InChI
InChI=1S/C8H6N2O/c11-7-3-5-9-6-2-1-4-10-8(6)7/h1-5H,(H,9,11)
InChIKey
NSPLFNGUPLZYHV-UHFFFAOYSA-N
SMILES
N1C2C(=NC=CC=2)C(O)=CC=1
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
B504318
Product name
1,5-Naphthyridin-4-ol
Packaging
50mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR951046
Product name
4-Hydroxy-1,5-naphthyridine
Purity
95%
Packaging
100mg
Price
$100
Updated
2021/12/16
Matrix Scientific
Product number
076465
Product name
4-Hydroxy-1,5-naphthyridine
Purity
95+%
Packaging
250mg
Price
$118
Updated
2021/12/16
Apolloscientific
Product number
OR951046
Product name
4-Hydroxy-1,5-naphthyridine
Purity
95%
Packaging
250mg
Price
$150
Updated
2021/12/16
Matrix Scientific
Product number
076465
Product name
4-Hydroxy-1,5-naphthyridine
Purity
95+%
Packaging
500mg
Price
$153
Updated
2021/12/16
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4-Hydroxy-1,5-naphthyridine Chemical Properties,Usage,Production

Uses

4-Hydroxy-1,5-Naphthidine is a heterocyclic derivative that can be used as an intermediate in organic synthesis.

Synthesis

25063-68-7

5423-54-1

General procedure for the synthesis of 4-hydroxy-1,5-naphthyridine (ZS96) from 2,2-dimethyl-5-((pyridin-3-ylamino)methylene)-1,3-dioxane-4,6-dione: ZS95 (100 mg, 0.403 mmol) was dissolved in diphenyl ether (3.0 mL) and refluxed for 50 min on a Bunsen burner. After completion of the reaction, the mixture was cooled to room temperature, the precipitate was collected by filtration and washed with hexane. The crude product was dried and purified by sublimation at 210 °C and 20 mbar to give white crystals ZS96 (40 mg, 68% yield).ZS96 sublimated slowly over 200 °C. IR (ATR, cm-1): 3012 (m), 2925 (s), 2855 (s), 2077 (w), 1975 (w), 1623 ( s), 1583 (m), 1559 (m), 1502 (s), 1461 (m), 1421 (m), 1328 (w), 1192 (w), 1137 (w), 1073 (w), 977 (w), 885 (w), 818 (w), 779 (w), 724 (w), 682 (w), 590 (w), 546 (w) , 481 (w).1H NMR (500 MHz, CDCl3 + d-TFA, δ): 9.15 (dd, J = 8.8, 1.2 Hz, 1H), 9.12-9.10 (m, 1H), 8.51 (d, J = 7.4 Hz, 1H), 8.41 (dd, J = 8.9, 5.4 Hz, 1H), 7.19 (d, J = 7.4 Hz, 1H). 13C NMR (125 MHz, CDCl3 + d-TFA, δ): 173.25, 147.30, 144.98, 142.03, 131.98, 131.43, 121.01, 116.06. HRMS: m/z 147.05496 [M+H]+, corresponds to molecular formula C8H6N2O (calculation error: -2.22 ppm).

References

[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 4, p. 1343 - 1361
[2] European Journal of Medicinal Chemistry, 2019, p. 32 - 50

4-Hydroxy-1,5-naphthyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxy-1,5-naphthyridine Suppliers

China 87 Europe 1 Germany 3 India 4 The Netherlands 1 United States 9 Global 105
Camida
Tel
--
Fax
--
Email
info@camida.com
Country
Europe
ProdList
3704
Advantage
71
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View Lastest Price from 4-Hydroxy-1,5-naphthyridine manufacturers

Career Henan Chemical Co
Product
4-Hydroxy-1,5-naphthyridine 5423-54-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-09

5423-54-1, 4-Hydroxy-1,5-naphthyridineRelated Search:

HYDROXYAPATITE TYPE I 4-Hydroxybenzaldehyde 4-Cyanophenol Nalidixic acid 4-Hydroxybenzoic acid Chrysin 10-Hydroxycamptothecin Hydroxy silicone oil Glycolic acid 1,6-NAPHTHYRIDINE CHLOROPHOSPHONAZO III APALCILLIN 4-HYDROXY-1,5-NAPHTHYRIDINE-3-CARBOXYLIC ACID Ethyl 4-Hydroxy-[1,5]naphthyridine-3-carboxylate,4-HYDROXY-[1,5]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER (2S,3S)-(2S,3R)-2-AMINO-3-HYDROXY-4-METHYLPENTANOIC ACID 7-AMINO-2-HYDROXY-1,8-NAPHTHYRIDINE-4-CARBOXYLIC ACID 1,5-NAPHTHYRIDINE 4-hydroxy[1,6]naphthyridine-3-carboxylic acid

  • [1,5]NAPHTHYRIDIN-4-OL
  • 4-HYDROXY-1,5-NAPHTHYRIDINE
  • 8-Hydroxy-1,5-naphthyridine
  • 1,5phthyridin-4-ol
  • 1H-Imidazole-4-carboxylicacid,1-(8-bromophenyl)-
  • Benzoicacid,3-bromo-,1,6-dimethylethylester
  • 4-Hydroxy-1,5-naphthyridine?New
  • 5423-54-1
  • Heterocycle-Pyridine series