ChemicalBook > CAS DataBase List > 1,5-NAPHTHYRIDINE

1,5-NAPHTHYRIDINE

Product Name
1,5-NAPHTHYRIDINE
CAS No.
254-79-5
Chemical Name
1,5-NAPHTHYRIDINE
Synonyms
1,5-DIAZANAPHTHALENE;1,5phthyridine;1, 5 - nalidixic;1,5-NAPHTHYRIDINE;1,5-Pyridopyridine;1,5-Naphthyridine>Pyrido[3,2-b]pyridine;PYRIDO[1,5-B]PYRIDINE;1,5-Naphthyridine 97%;1,5-Naphthyridine, 97+%
CBNumber
CB1313088
Molecular Formula
C8H6N2
Formula Weight
130.15
MOL File
254-79-5.mol
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1,5-NAPHTHYRIDINE Property

Melting point:
69-75 °C
Boiling point:
152 °C / 54mmHg
Density 
1.25
refractive index 
1.6231 (estimate)
storage temp. 
Sealed in dry,Room Temperature
pka
2.90±0.10(Predicted)
form 
Solid
color 
Off-white
InChI
InChI=1S/C8H6N2/c1-3-7-8(9-5-1)4-2-6-10-7/h1-6H
InChIKey
VMLKTERJLVWEJJ-UHFFFAOYSA-N
SMILES
N1C2C(=NC=CC=2)C=CC=1
CAS DataBase Reference
254-79-5(CAS DataBase Reference)
NIST Chemistry Reference
1,5-Naphthyridine(254-79-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-41-37/38-22
Safety Statements 
26-36/37/39-39
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
673218
Product name
1,5-Naphthyridine
Purity
96%
Packaging
1g
Price
$68
Updated
2025/07/31
TCI Chemical
Product number
N0401
Product name
1,5-Naphthyridine
Purity
>98.0%(T)
Packaging
100mg
Price
$16
Updated
2025/07/31
TCI Chemical
Product number
N0401
Product name
1,5-Naphthyridine
Purity
>98.0%(T)
Packaging
1g
Price
$114
Updated
2025/07/31
TRC
Product number
N325013
Product name
1,5-Naphthyridine
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
J91109
Product name
1,5-Naphthyridine
Packaging
1g
Price
$27
Updated
2021/12/16
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1,5-NAPHTHYRIDINE Chemical Properties,Usage,Production

Chemical Properties

off-whtie solid

Definition

ChEBI: 1,5-naphthyridine is a naphthyridine.

Synthesis

462-08-8

56-81-5

254-79-5

Synthesis of 1,5-naphthyridine (4): To a round bottom flask was added 3-aminopyridine (1 g, 10.63 mmol), sodium m-nitrobenzenesulfonate (3.59 g, 15.95 mmol), glycerol (3.33 mL, 46.85 mmol), concentrated sulfuric acid (5.92 mL, 111.53 mmol) and water (3 mL). The reaction mixture was heated to 150 °C and stirred continuously for 2.5 hours. Upon completion of the reaction, it was cooled to room temperature and the pH was adjusted to 8 with 4 M sodium hydroxide solution, followed by extraction with ethyl acetate (5 x 30 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by column chromatography (petroleum ether/ethyl acetate=1:1) afforded the target product 1,5-naphthyridine (622 mg, 45% yield) as a yellow solid. Melting point: 74~75°C (literature value 75°C). 1H NMR (400MHz, CDCl3): δ9.04-8.96 (m, 2H), 8.43 (d, J=8.4Hz, 2H), 7.66 (dd, J=8.4,4.1Hz, 2H).

Purification Methods

Purify 1,5-naphthyridine by repeated sublimation. The picrate crystallises from EtOH with m 200o(dec). [UV: Armarego Physical Methods in Heterocyclic Chemistry (Ed Katritzky, Academic Press) Vol III 133 1971, Beilstein 23 II 178, 23 III/IV 1235.]

References

[1] Synthetic Communications, 2011, vol. 41, # 12, p. 1843 - 1851
[2] Tetrahedron Letters, 2002, vol. 43, # 20, p. 3747 - 3750
[3] Organic Letters, 2000, vol. 2, # 7, p. 875 - 878
[4] Chemistry - A European Journal, 2017, vol. 23, # 53, p. 13046 - 13050
[5] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 16, p. 3251 - 3255

1,5-NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,5-NAPHTHYRIDINE manufacturers

Dideu Industries Group Limited
Product
1,5-NAPHTHYRIDINE 254-79-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
1,5-NAPHTHYRIDINE 254-79-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
1,5-NAPHTHYRIDINE 254-79-5
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
customise
Release date
2018-08-09

254-79-5, 1,5-NAPHTHYRIDINERelated Search:

5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDIN-3-OL 1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro- 2,7-NAPHTHYRIDINE, 1-CHLORO- 6-benzyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one 4-HYDROXY-1,5-NAPHTHYRIDINE-3-CARBOXYLIC ACID APALCILLIN 1,5-NAPHTHYRIDINE 1,5-NAPHTHYRIDIN-4-AMINE 4-HYDROXY-[1,5]NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 7,10-dichloro-2-methoxybenzo[b]-1,5-naphthyridine [1,5]-NAPHTHYRIDIN-2-YLAMINE Pyronaridine 4-HYDROXY-1,5-NAPHTHYRIDINE 2-Bromo-1,5-naphthyridine 5-chloro-1,2,3,4-tetrahydro-1,6-naphthyridine 7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid Aspoxicillin

  • 1,5-NAPHTHYRIDINE
  • 1,5-DIAZANAPHTHALENE
  • PYRIDO[1,5-B]PYRIDINE
  • 1,5-Pyridopyridine
  • 1,5-Naphthyridine(6CI,8CI,9CI)
  • Pyrido[3,2-b]pyridine
  • 1,5phthyridine
  • 1,5-Diazanaphthalene Pyrido[1,5-b]pyridine
  • 1,5-Naphthyridine, 97+%
  • 1,5-Naphthyridine&gt
  • 1, 5 - nalidixic
  • 1,5-NAPHTHYRIDINE ISO 9001：2015 REACH
  • 1,5-Naphthyridine 97%
  • 254-79-5
  • 245-79-5
  • Building Blocks
  • Heterocyclic Building Blocks
  • Others
  • N-Containing
  • Heterocycle-Pyridine series
  • Building Blocks
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • PYRIDINE
  • N-Containing
  • Heterocyclic Building Blocks
  • Others
  • Intermediates