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Pyronaridine

Product Name
Pyronaridine
CAS No.
74847-35-1
Chemical Name
Pyronaridine
Synonyms
Pyronaridine;Malaridine phosphate;4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-...;4-(2-Methoxy-6-chloro-1,10-diazaanthracene-9-ylamino)-2,6-bis(pyrrolizinomethyl)phenol;4-(7-chloro-2-Methoxybenzo[b][1,5]naphthyridin-10-ylaMino)-2,6-bis(pyrrolidin-1-ylMethyl)phenol;4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol;Phenol, 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-;4-[(7-CHLORO-2-METHOXY-1,5-DIHYDROBENZO[B][1,5]NAPHTHYRIDIN-10-YL)IMINO]-2,6-BIS(PYRROLIDIN-1-YLMETHYL)CYCLOHEXA-2,5-DIEN-1-ONE
CBNumber
CB01179619
Molecular Formula
C29H32ClN5O2
Formula Weight
518.05
MOL File
74847-35-1.mol
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Pyronaridine Property

Boiling point:
621.3±55.0 °C(Predicted)
Density 
1.356±0.06 g/cm3 (20℃ 760 Torr)
refractive index 
1.5650 (estimate)
solubility 
DMSO (Slightly), Water (Slightly)
form 
Solid
pka
8.20±0.50(Predicted)
color 
Light Yellow to Orange
Stability:
Incompatible with strong oxidizing agents.
CAS DataBase Reference
74847-35-1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0009302
Product name
PYRONARIDINE
Purity
95.00%
Packaging
5MG
Price
$500.79
Updated
2021/12/16
AvaChem
Product number
1554B
Product name
Pyronaridine
Packaging
5g
Price
$1950
Updated
2021/12/16
DC Chemicals
Product number
DC10691
Product name
Pyronaridine
Purity
>98%
Packaging
1g
Price
$2000
Updated
2021/12/16
AvaChem
Product number
1554B
Product name
Pyronaridine
Packaging
25mg
Price
$39
Updated
2021/12/16
AvaChem
Product number
1554B
Product name
Pyronaridine
Packaging
100mg
Price
$69
Updated
2021/12/16
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Pyronaridine Chemical Properties,Usage,Production

Chemical Properties

solid

Definition

ChEBI: Pyronaridine is an aminoquinoline.

Antimicrobial activity

Pyronaridine is active against the asexual erythrocytic stage of P. falciparum with little or no activity against gametocytes or the hepatic stage. In-vitro blood schizonticide activities are in the range of 0.001–0.03 mg/L, showing a moderate correlation to chloroquine resistance. However, this correlation varies between studies and does not seem to be clinically significant. It is also active against P. vivax, P. ovale and P. malariae. Antagonistic interactions with artemisinins were reported in vitro, but synergy with artesunate has been observed in rodent models.

Acquired resistance

Decreasing in-vitro sensitivity has been observed in China.

Pharmaceutical Applications

An aza-aminoacridine formulated for oral use. A Mannichbase derivative of mepacrine.

Pharmacokinetics

Peak plasma concentrations are reached after 3–14 h depending upon the formulation; there is also considerable interindividual variation. Elimination half-lives of 63–190 h have been reported, again dependent upon the formulation.

Clinical Use

Treatment of uncomplicated P. falciparum and P. vivax malaria
A fixed-dose combination with artesunate (Pyramax) is being developed for uncomplicated P. falciparum and P. vivax malaria.

Side effects

It is well tolerated and no outstanding toxic effects have been reported.

Pyronaridine Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyronaridine Suppliers

Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10276
Advantage
55
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
Advantage
58
Shanghai He Huan Chemical Co., Ltd.
Tel
021-60345187 13917602471
Fax
021-60345187
Email
lzz841106@aliyun.com
Country
China
ProdList
9897
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-0371-55051623 18137891487
Fax
QQ:2853979817
Email
2853979817@qq.com
Country
China
ProdList
9882
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3251
Advantage
58
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View Lastest Price from Pyronaridine manufacturers

airuikechemical co., ltd.
Product
Pyronaridine 74847-35-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
20 tons
Release date
2024-04-07
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Malaridine 74847-35-1
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-04-01
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Malaridine 74847-35-1
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-03-29

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