Pyronaridine

ChemicalBook > CAS DataBase List > Pyronaridine

Product Name: Pyronaridine
CAS No.: 74847-35-1
Chemical Name: Pyronaridine
Synonyms: Pyronaridine;Malaridine phosphate;4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-...;4-(2-Methoxy-6-chloro-1,10-diazaanthracene-9-ylamino)-2,6-bis(pyrrolizinomethyl)phenol;4-(7-chloro-2-Methoxybenzo[b][1,5]naphthyridin-10-ylaMino)-2,6-bis(pyrrolidin-1-ylMethyl)phenol;4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol;Phenol, 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-;4-[(7-CHLORO-2-METHOXY-1,5-DIHYDROBENZO[B][1,5]NAPHTHYRIDIN-10-YL)IMINO]-2,6-BIS(PYRROLIDIN-1-YLMETHYL)CYCLOHEXA-2,5-DIEN-1-ONE
CBNumber: CB01179619
Molecular Formula: C29H32ClN5O2
Formula Weight: 518.05
MOL File: 74847-35-1.mol

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Pyronaridine Property

Boiling point:: 621.3±55.0 °C(Predicted)
Density: 1.356±0.06 g/cm3 (20℃ 760 Torr)
refractive index: 1.5650 (estimate)
solubility: DMSO (Slightly), Water (Slightly)
form: Solid
pka: 8.20±0.50(Predicted)
color: Light Yellow to Orange
Stability:: Incompatible with strong oxidizing agents.
CAS DataBase Reference: 74847-35-1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0009302
Product name: PYRONARIDINE
Purity: 95.00%
Packaging: 5MG
Price: $500.79
Updated: 2021/12/16

AvaChem

Product number: 1554B
Product name: Pyronaridine
Packaging: 5g
Price: $1950
Updated: 2021/12/16

DC Chemicals

Product number: DC10691
Product name: Pyronaridine
Purity: >98%
Packaging: 1g
Price: $2000
Updated: 2021/12/16

AvaChem

Product number: 1554B
Product name: Pyronaridine
Packaging: 25mg
Price: $39
Updated: 2021/12/16

AvaChem

Product number: 1554B
Product name: Pyronaridine
Packaging: 100mg
Price: $69
Updated: 2021/12/16

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Pyronaridine Chemical Properties,Usage,Production

Chemical Properties

solid

Definition

ChEBI: Pyronaridine is an aminoquinoline.

Antimicrobial activity

Pyronaridine is active against the asexual erythrocytic stage of P. falciparum with little or no activity against gametocytes or the hepatic stage. In-vitro blood schizonticide activities are in the range of 0.001–0.03 mg/L, showing a moderate correlation to chloroquine resistance. However, this correlation varies between studies and does not seem to be clinically significant. It is also active against P. vivax, P. ovale and P. malariae. Antagonistic interactions with artemisinins were reported in vitro, but synergy with artesunate has been observed in rodent models.

Acquired resistance

Decreasing in-vitro sensitivity has been observed in China.

Pharmaceutical Applications

An aza-aminoacridine formulated for oral use. A Mannichbase derivative of mepacrine.

Pharmacokinetics

Peak plasma concentrations are reached after 3–14 h depending upon the formulation; there is also considerable interindividual variation. Elimination half-lives of 63–190 h have been reported, again dependent upon the formulation.

Clinical Use

Treatment of uncomplicated P. falciparum and P. vivax malaria
A fixed-dose combination with artesunate (Pyramax) is being developed for uncomplicated P. falciparum and P. vivax malaria.

Side effects

It is well tolerated and no outstanding toxic effects have been reported.

Pyronaridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pyronaridine manufacturers

airuikechemical co., ltd.

Product: Pyronaridine 74847-35-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 20 tons
Release date: 2024-04-07

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Malaridine 74847-35-1
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-01

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Malaridine 74847-35-1
Price: US $0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-03-29

74847-35-1, PyronaridineRelated Search:

Potassium Phosphate Monobasic 1,5-NAPHTHYRIDINE Amodiaquin dihydrochloride dihydrate 1,5-NAPHTHYRIDIN-4-AMINE 2-Hydroxy-1,5-naphthyridine Pyranoridine phosphate N-DESETHYL AMODIAQUINE 3-(PYRROLIDIN-1-YLMETHYL)ANILINE M6407 [3-(1-PYRROLIDINYLMETHYL)PHENYL]METHANAMINE 1-{3-[(METHYLAMINO)METHYL]BENZYL}PYRROLIDINE 90+%N-METHYL-3-(PYRROLIDIN-1-YLMETHYL)BENZYLAMINE 7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE Pyronaridine Amopyroquine

4-[(7-CHLORO-2-METHOXY-1,5-DIHYDROBENZO[B][1,5]NAPHTHYRIDIN-10-YL)IMINO]-2,6-BIS(PYRROLIDIN-1-YLMETHYL)CYCLOHEXA-2,5-DIEN-1-ONE

Malaridine phosphate

4-(7-chloro-2-Methoxybenzo[b][1,5]naphthyridin-10-ylaMino)-2,6-bis(pyrrolidin-1-ylMethyl)phenol

Pyronaridine

4-(2-Methoxy-6-chloro-1,10-diazaanthracene-9-ylamino)-2,6-bis(pyrrolizinomethyl)phenol

4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol

Phenol, 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-

4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-...

74847-35-1

C29H32ClN5O2

john's