ISOVALERYL-L-CARNITINE CHLORIDE
- Product Name
- ISOVALERYL-L-CARNITINE CHLORIDE
- CAS No.
- 139144-12-0
- Chemical Name
- ISOVALERYL-L-CARNITINE CHLORIDE
- Synonyms
- Isovalerylcarnitine chloride;ISOVALERYL-L-CARNITINE CHLORIDE;Isovaleryl-L-carnitine HCl in Water;L-CARNITINE:HCL, O-ISOVALERYL UNLABELED;Isovaleryl-L-carnitine-d3 HCl (N-methyl-d3);1-Propanaminium,3-carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-, chloride, (2R)-
- CBNumber
- CB21511110
- Molecular Formula
- C12H22ClNO3
- Formula Weight
- 263.76098
- MOL File
- 139144-12-0.mol
ISOVALERYL-L-CARNITINE CHLORIDE Property
- Melting point:
- >160°C (dec.)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Methanol (Slightly), Water (Slightly, Heated)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- CAS Number Unlabeled
- 139144-12-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26555
- Product name
- Isovaleryl-L-carnitine (chloride)
- Packaging
- 25mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 26555
- Product name
- Isovaleryl-L-carnitine (chloride)
- Packaging
- 100mg
- Price
- $346
- Updated
- 2024/03/01
- Product number
- 26555
- Product name
- Isovaleryl-L-carnitine (chloride)
- Packaging
- 50mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- I917580
- Product name
- IsovalerylL-CarnitineChloride
- Packaging
- 100mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- I917580
- Product name
- IsovalerylL-CarnitineChloride
- Packaging
- 1g
- Price
- $1355
- Updated
- 2021/12/16
ISOVALERYL-L-CARNITINE CHLORIDE Chemical Properties,Usage,Production
Description
Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia).
Uses
Isovaleryl L-Carnitine Chloride is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.
IC 50
Human Endogenous Metabolite
References
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] ROBERTO PAOLO REVOLTELLA . l-Carnitine and some of its analogs delay the onset of apoptotic cell death initiated in murine C2.8 hepatocytic cells after hepatocyte growth factor deprivation[J]. Biochimica et biophysica acta. Molecular cell research, 1994, 1224 3: Pages 333-341. DOI: 10.1016/0167-4889(94)90265-8
[3] G MIOTTO. Control of hepatic proteolysis by leucine and isovaleryl-L-carnitine through a common locus. Evidence for a possible mechanism of recognition at the plasma membrane.[J]. The Journal of Biological Chemistry, 1992, 267 31: 22066-22072.
[4] PIERO RINALDO Dietrich M Tina M Cowan. Acylcarnitine profile analysis[J]. Genetics in Medicine, 2008, 10 2: Pages 151-156. DOI: 10.1097/gim.0b013e3181614289
ISOVALERYL-L-CARNITINE CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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