6-BROMOMETHYL-2-CYANOPYRIDINE
- Product Name
- 6-BROMOMETHYL-2-CYANOPYRIDINE
- CAS No.
- 104508-24-9
- Chemical Name
- 6-BROMOMETHYL-2-CYANOPYRIDINE
- Synonyms
- 6-BROMOMETHYL-2-CYANOPYRIDINE;2-Bromomethyl-6-cyanopyridine;6-(broMoMethyl)picolinonitrile;6-Bromomethylpyridin-2-carbonitrile;6-Bromomethyl-2-pyridinecarbonitrile;6-Bromomethyl-pyridine-2-carbonitrile;2-Pyridinecarbonitrile, 6-(bromomethyl)-
- CBNumber
- CB21519666
- Molecular Formula
- C7H5BrN2
- Formula Weight
- 197.03
- MOL File
- 104508-24-9.mol
6-BROMOMETHYL-2-CYANOPYRIDINE Property
- Boiling point:
- 293℃
- Density
- 1.60
- Flash point:
- 131℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- solid
- pka
- -2.11±0.12(Predicted)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B681005
- Product name
- 6-Bromomethyl-2-cyanopyridine
- Packaging
- 50mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- FB159274
- Product name
- 6-Bromomethyl-2-pyridinecarbonitrile
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FB159274
- Product name
- 6-Bromomethyl-2-pyridinecarbonitrile
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- OR314010
- Product name
- 6-Bromomethyl-2-cyanopyridine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $243
- Updated
- 2021/12/16
- Product number
- 3H37-9-0C
- Product name
- 6-Bromomethyl-2-cyanopyridine
- Purity
- 95.0%
- Packaging
- 250mg
- Price
- $268
- Updated
- 2021/12/16
6-BROMOMETHYL-2-CYANOPYRIDINE Chemical Properties,Usage,Production
Synthesis
1620-75-3
104508-24-9
General procedure for the synthesis of 6-(bromomethyl)-2-cyanopyridine from 6-methyl-2-pyridinecarbonitrile: 400 mg (3.39 mmol) of 2-cyano-6-methylpyridine was dissolved in 12 mL of chloroform, 723 mg (4.06 mmol) of N-bromosuccinimide (NBS) and 28 mg (0.17 mmol) of azobisisobutyronitrile ( AIBN). The reaction mixture was heated to reflux and irradiated with UV lamp for 4 h (the reaction progress was monitored by TLC, silica gel plates, dichloromethane as eluent, Rf = 0.43). After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with a continuous gradient of 85/15 (v/v) dichloromethane/heptane to pure dichloromethane as eluent. Finally, 290 mg of 6-(bromomethyl)-2-cyanopyridine in white microcrystalline powder form was obtained in 43% yield.1H NMR (200 MHz, CDCl3) δ ppm: 4.55 (s, 2H, pyCH2Br), 7.63 (dd, J = 7.63, 1.27 Hz, 1H, H3), 7.70 (dd, J = 7.95, 1.27 Hz, 1H, H1), 7.87 (t, J = 7.95, 7.63 Hz, 1H, H2).
References
[1] Patent: US2011/112289, 2011, A1. Location in patent: Page/Page column 10
[2] Journal of the American Chemical Society, 2008, vol. 130, # 8, p. 2414 - 2415
6-BROMOMETHYL-2-CYANOPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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