1-[2-AMino-1-(4-Methoxyphenyl)ethyl]cyclohexanol

Synthesis

Product Name: 1-[2-AMino-1-(4-Methoxyphenyl)ethyl]cyclohexanol
CAS No.: 93413-77-5
Chemical Name: 1-[2-AMino-1-(4-Methoxyphenyl)ethyl]cyclohexanol
Synonyms: Dinorvenlafaxin;Dinorvenlafaxine;Venlafaxine intermediate;Venlafaxine EP IMpurity C;N,N-didesmethylvenlafaxine;D,L-N,N-Didesmethylvenlafaxine;1-[2-AMINO-1-(4-METHOXYPHENYL)ETHYL]CYCLOHEXANOL;1-(4-Methoxyphenyl)-2-aminoethyl cyclohexanol hydr;1-[2-aMino-1-(4-Methoxyphenyl)ethyl]cyclohexan-1-ol;1-[2-amino-1-(4-methoxyphenyl)ethyl]-1-cyclohexanol
CBNumber: CB2154879
Molecular Formula: C15H23NO2
Formula Weight: 249.35
MOL File: 93413-77-5.mol

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1-[2-AMino-1-(4-Methoxyphenyl)ethyl]cyclohexanol Property

Melting point:: 102-105 °C
Boiling point:: 394.6±22.0 °C(Predicted)
Density: 1.107±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: soluble in DCM, Methanol
pka: 14.75±0.20(Predicted)
form: Oil
color: Brown
CAS DataBase Reference: 93413-77-5(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 009398
Product name: D,L-N,N-Didesmethyl Venlafaxine|
Packaging: 25mg
Price: $446
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0046128
Product name: VENLAFAXINE EP IMPURITY C
Purity: 95.00%
Packaging: 5MG
Price: $451.27
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21749
Product name: D,L-N,N-Didesmethyl venlafaxine
Packaging: 50mg
Price: $462
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000718
Product name: 1-[2-AMINO-1-(4-METHOXYPHENYL)ETHYL]CYCLOHEXANOL
Purity: 95.00%
Packaging: 25MG
Price: $739.2
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 9343
Product name: D,L-N,N-DidesmethylVenlafaxine
Packaging: 10mg
Price: $820
Updated: 2021/12/16

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1-[2-AMino-1-(4-Methoxyphenyl)ethyl]cyclohexanol Chemical Properties,Usage,Production

Synthesis

To a mechanically stirred solution of AlCl3 (103.60 g, 0.779 mol) in THF (900 ml), at 0 ºC, LiAlH4 (59.80 g, 1.575 mol) was added cautiously, in portions. Temperature was maintained below 10 ºC. A solution of 2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl) acetonitrile(130.0 g, 0.530 mol) in THF (500 ml) was added drop-wise over a period of 1.5 hours. The reaction mixture was then brought to room temperature and stirred for 30 minutes. The reaction mixture was again cooled in an ice-salt bath. The reaction was quenched with ethyl acetate (60 ml) maintaining the temperature below 10 ºC. The reaction mixture was then transferred to a beaker, cooled externally in an ice-salt bath and treated very cautiously with 25% aq. NaOH solution (360 ml) with mechanical stirring. (After addition of about 50 ml 25% aq. NaOH solution, a hard solid was formed, cooling was removed and the contents were stirred manually during the addition of remaining NaOH solution). The solid was loosened at room temperature, which was further stirred for 1 hour. A bright white solid appeared. The solid was filtered off, washed thoroughly with ethyl acetate. The filtrate was concentrated in vacuo and combined with the above washings, washed with brine, dried over anhydrous Na2SO4, filtered and ethyl acetate removed under reduced pressure to obtain aminoalcohol 38 as a thick yellow oil (129.4 g).

Chemical Properties

Pale Yellow Oil

Uses

An intermediate in the synthesis of N,O-Didesmethylvenlafaxine, a metabolite of Venlafaxine

Definition

ChEBI: A monomethoxybenzene that is the N,N-didesmethyl derivative of venlafaxine.

1-[2-AMino-1-(4-Methoxyphenyl)ethyl]cyclohexanol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[2-AMino-1-(4-Methoxyphenyl)ethyl]cyclohexanol Suppliers

Canada 1 China 75 Europe 2 France 1 Germany 1 India 8 United Kingdom 6 United States 17 Global 111

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View Lastest Price from 1-[2-AMino-1-(4-Methoxyphenyl)ethyl]cyclohexanol manufacturers

Career Henan Chemical Co

Product: 1-(4-Methoxyphenyl)-2-aminoethyl cyclohexanol hydrochlorideS 93413-77-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 100KG
Release date: 2019-08-29

93413-77-5, 1-[2-AMino-1-(4-Methoxyphenyl)ethyl]cyclohexanol Related Search:

p-(2-Methoxyethyl) phenol Ethyl acetate Ethylparaben 2-(2-Aminoethylamino)ethanol Cyclohexanol (Trifluoromethoxy)benzene Cyclohexylamine hydrochloride 4-Methoxyphenylacetone Methoxydiethylborane Topotecan hydrochloride rac N,N-DidesMethyl-N-(4-hydroxyphenethyl)-O-desMethyl Venlafaxine Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate Venlafaxine Impurity1 O-DesMethyl Venlafaxine Cyclic IMpurity Venlafaxine Impurity 10 DesMethoxy Venlafaxine Hydrochloride 4a(2H)-Isoquinolinol, octahydro-4-(4-methoxyphenyl)-2-methyl- VenlafaxineImpurity3

1-[2-aMino-1-(4-Methoxyphenyl)ethyl]cyclohexan-1-ol

Venlafaxine EP IMpurity C

2-(4-Methoxyphenyl)-2-(1-hydroxycyclohexyl)-ethylamine

Venlafaxine intermediate

D,L-N,N-Didesmethylvenlafaxine

1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol(see D441570)

Dinorvenlafaxine

Dinorvenlafaxin

1-(2-Amino-1-[(4methoxy-2-(phenylethyl)]-cyclohexanol

N,N-didesmethylvenlafaxine

1-[2-AMINO-1-(4-METHOXYPHENYL)ETHYL]CYCLOHEXANOL HCL

1-(4-METHOXYPHENYL)-2-AMINOETHYL CYCLOHEXANOL HYDROCHLORIDE

2-(4-METHOXYPHENYL)-2-(1-HYDROXYCYCLOHEXYL)ETHYLAMINE HYDROCHLORIDE

1-[2-amino-1-(4-methoxyphenyl)ethyl]-1-cyclohexanol

1-(4-Methoxyphenyl)-2-aminoethyl cyclohexanol hydrochlorideS

Venlafaxine EP Impurity C/1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol

1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol DISCONTINUED. Please see A611968

D,L-N,N-Didesmethyl Venlafaxine DISCONTINUED. Please see A611968

1-[2-AMINO-1-(4-METHOXYPHENYL)ETHYL]CYCLOHEXANOL

1-(4-Methoxyphenyl)-2-aminoethyl cyclohexanol hydr

93413-77-5

C15H23NO2HCI

Velafaxine

Various Metabolites and Impurities

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals