N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride

Product Name: N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride
CAS No.: 2730-52-1
Chemical Name: N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride
Synonyms: Upadacitinib Impurity 86 Hydrochloride;Methyl(2,2,2-trifluoroethyl)aMine, HCl;2,2,2-Trifluoro-N-MethylethanaMine HCl;N-Methyl-N-(2,2,2-trifluoroethyl)aMine HCl;2,2,2-TRIFLUORO-N-METHYLETHANAMINIUM CHLORIDE;N-Methyl-2,2,2-trifluoroethylamine Hydrochloride;2,2,2-trifluoro-N-methylethan-1-amine hydrochloride;N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride;2,2,2-trifluoro-N-methyl-Ethanamine hydrochloride (1:1);Ethanamine, 2,2,2-trifluoro-N-methyl-, hydrochloride (1:1)
CBNumber: CB21552922
Molecular Formula: C3H7ClF3N
Formula Weight: 149.54
MOL File: 2730-52-1.mol

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N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Property

Melting point:: >200 °C (sublm)(Solv: ethanol (64-17-5))
storage temp.: Inert atmosphere,Room Temperature
form: solid
color: White
InChI: InChI=1S/C3H6F3N.ClH/c1-7-2-3(4,5)6;/h7H,2H2,1H3;1H
InChIKey: CUOWKFXFKFXJEL-UHFFFAOYSA-N
SMILES: C(CNC)(F)(F)F.[H]Cl

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Safety

WGK Germany: WGK 3
HazardClass: IRRITANT
HS Code: 2921199990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Eye Irrit. 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS001773
Product name: N-Methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 25 mg
Price: $73.1
Updated: 2025/07/31

TRC

Product number: T792695
Product name: 2,2,2-Trifluoro-N-methylethanamineHydrochloride
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 021250
Product name: Methyl-(2,2,2-trifluoro-ethyl)-amine hydrochloride
Packaging: 500mg
Price: $78
Updated: 2021/12/16

Matrix Scientific

Product number: 021250
Product name: Methyl-(2,2,2-trifluoro-ethyl)-amine hydrochloride
Packaging: 1g
Price: $119
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3131-7-02
Product name: Methyl(2,2,2-trifluoroethyl)amine hydrochloride
Purity: 97%
Packaging: 250mg
Price: $191
Updated: 2021/12/16

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N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Chemical Properties,Usage,Production

Synthesis

815-06-5

2730-52-1

General procedure for the synthesis of N-methyl-2,2,2-trifluoroacetamide hydrochloride from N-methyl-2,2,2-trifluoroacetamide: A solution was prepared by dissolving lithium aluminum hydride (69 g, 1.8 mol) in 100 mL of ether at 100 °C. To this solution, an ether solution of 2,2,2-trifluoro-N-methylacetamide (86 g, 0.6 mol) was slowly added at 0 °C. The reaction mixture was stirred at room temperature overnight. Subsequently, sodium sulfate decahydrate was added to the mixture at -10°C and the resulting suspension was filtered. Dry HCl gas was passed into the filtrate until a white solid precipitated. The solid product was separated by filtration and recrystallized with a solvent mixture of methanol/ether to give N-methyl-2,2,2-trifluoroethylamine hydrochloride as a final white solid (73 g, 80.7% yield).

References

[1] Patent: WO2010/131145, 2010, A1. Location in patent: Page/Page column 76

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride Suppliers

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2730-52-1, N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochlorideRelated Search:

(S)-(-)-N-(TRIFLUOROACETYL)PROLYL CHLORIDE (3S)-(-)-3-(TRIFLUOROACETAMIDO)PYRROLIDINE HYDROCHLORIDE 1-(2,6-DICHLOROBENZYL)-2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBOXAMIDE 1-(3,4-DICHLOROBENZYL)-2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBOXAMIDE 4-chloro-2-[(2,2,2-trifluoroacetyl)amino]benzenecarboxylic acid 1-(4-CHLOROBENZYL)-2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBOXAMIDE 1-(3,4-DICHLOROBENZYL)-2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE ETHYL 2-CHLORO-2-[(2,4-DICHLOROBENZOYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-CHLORO-2-[(3-CHLOROBENZOYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-(ACETYLAMINO)-2-CHLORO-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-CHLORO-2-[(4-CHLOROBENZOYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-CHLORO-3,3,3-TRIFLUORO-2-(PROPIONYLAMINO)PROPANOATE N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)-2,2,2-TRIFLUOROACETAMIDE ETHYL 2-CHLORO-2-[(2-CHLOROACETYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-CHLORO-2-[(ETHOXYCARBONYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE 2,3,3-TRICHLORO-1-[1-(TRIFLUOROMETHYL)-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLIN-2-YL]PROP-2-EN-1-ONE N-[1-(2,6-DICHLOROBENZYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINYL]-2,2,2-TRIFLUOROACETAMIDE 1-(4-CHLOROBENZYL)-2-OXO-6-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE

N-methyl-N-(2,2,2-trifluoroethyl)amine hydrochloride

2,2,2-TRIFLUORO-N-METHYLETHANAMINIUM CHLORIDE

Methyl(2,2,2-trifluoroethyl)aMine, HCl

N-Methyl-N-(2,2,2-trifluoroethyl)aMine HCl

2,2,2-Trifluoro-N-MethylethanaMine HCl

N-Methyl-2,2,2-trifluoroethylamine Hydrochloride

Ethanamine, 2,2,2-trifluoro-N-methyl-, hydrochloride (1:1)

2,2,2-trifluoro-N-methyl-Ethanamine hydrochloride (1:1)

2,2,2-trifluoro-N-methylethan-1-amine hydrochloride

Upadacitinib Impurity 86 Hydrochloride

2730-52-1