2-(4-bromo-2-chlorophenyl)acetic acid
- Product Name
- 2-(4-bromo-2-chlorophenyl)acetic acid
- CAS No.
- 916516-89-7
- Chemical Name
- 2-(4-bromo-2-chlorophenyl)acetic acid
- Synonyms
- 4-Bromo-2-chlorobenzeneacetic acid;Benzeneacetic acid, 4-broMo-2-chloro-;2-(4-bromo-2-chlorophenyl)acetic acid
- CBNumber
- CB21557053
- Molecular Formula
- C8H6BrClO2
- Formula Weight
- 249.49
- MOL File
- 916516-89-7.mol
2-(4-bromo-2-chlorophenyl)acetic acid Property
- Boiling point:
- 353.2±27.0 °C(Predicted)
- Density
- 1.720±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.92±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- B700315
- Product name
- 2-(4-Bromo-2-chlorophenyl)aceticAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2721-D-02
- Product name
- 4-Bromo-2-chlorophenylacetic acid
- Purity
- tech%
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB45416
- Product name
- 2-(4-Bromo-2-chlorophenyl)acetic acid
- Packaging
- 2g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB45416
- Product name
- 2-(4-Bromo-2-chlorophenyl)acetic acid
- Packaging
- 5G
- Price
- $120
- Updated
- 2021/12/16
- Product number
- J96287
- Product name
- 2-(4-Bromo-2-chlorophenyl)aceticacid
- Packaging
- 5g
- Price
- $120
- Updated
- 2021/12/16
2-(4-bromo-2-chlorophenyl)acetic acid Chemical Properties,Usage,Production
Synthesis
67197-54-0
916516-89-7
In a round-bottomed flask, 2-chloro-4-bromophenylacetonitrile (19.0 g, 82.4 mmol, 1.0 eq.) was dissolved in water (196 mL), followed by the addition of potassium hydroxide (KOH, 23.1 g, 412 mmol, 5.0 eq.). The reaction mixture was heated to reflux and stirred for 12-18 hours. After completion of the reaction, it was cooled to room temperature and washed with ethyl acetate (EtOAc) to remove organic impurities. The aqueous phase was acidified with 2N hydrochloric acid to pH < 2 and subsequently extracted with ethyl acetate (150 mL x 3). The organic phases were combined, washed with saturated sodium chloride solution (brine), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford 2-(4-bromo-2-chlorophenyl)acetic acid (S3) as brown crystals (19.1 g, 93% yield). The product characterization data were in agreement with literature reports. [20]
References
[1] Tetrahedron Letters, 2016, vol. 57, # 3, p. 449 - 451
[2] Patent: WO2013/43232, 2013, A2. Location in patent: Paragraph 00502
[3] Patent: EP2017257, 2009, A1. Location in patent: Page/Page column 21-22
[4] Patent: JP2015/231988, 2015, A. Location in patent: Paragraph 0361; 0362
2-(4-bromo-2-chlorophenyl)acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-(4-bromo-2-chlorophenyl)acetic acid manufacturers
- Product
- 2-(4-bromo-2-chlorophenyl)acetic acid 916516-89-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2018-12-17