4-(4-Boc-piperazin-1-yl)-3-fluoroaniline
- Product Name
- 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline
- CAS No.
- 154590-35-9
- Chemical Name
- 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline
- Synonyms
- 4-(4-Boc-1-piperazinyl)-3-fluoroaniline;4-(4-Boc-piperazin-1-yl)-3-fluoroaniline;3-Fluoro-4-[4-(Boc-amino)piperidino]aniline;4-(4-Amino-2-fluorophenyl)-1-Boc-piperazine;4-(4-Boc-piperazin-1-yl)-3-fluoroaniline ISO 9001：2015 REACH;4-(4-Amino-2-fluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 4-(4-amino-2-fluorophenyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB21562066
- Molecular Formula
- C15H22FN3O2
- Formula Weight
- 295.35
- MOL File
- 154590-35-9.mol
4-(4-Boc-piperazin-1-yl)-3-fluoroaniline Property
- Boiling point:
- 439.6±45.0 °C(Predicted)
- Density
- 1.198±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- solid
- pka
- 6.67±0.10(Predicted)
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C15H22FN3O2/c1-15(2,3)21-14(20)19-8-6-18(7-9-19)13-5-4-11(17)10-12(13)16/h4-5,10H,6-9,17H2,1-3H3
- InChIKey
- IULXQAJBODFBAK-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)C=C2F)CC1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- B809878
- Product name
- tert-Butyl4-(4-Amino-2-fluorophenyl)piperazine-1-carboxylate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- PC8788
- Product name
- 4-(4-Amino-2-fluorophenyl)piperazine,N1-BOCprotected
- Packaging
- 250mg
- Price
- $13
- Updated
- 2021/12/16
- Product number
- 046131
- Product name
- tert-Butyl 4-(4-amino-2-fluorophenyl)tetrahydro-1(2H)-pyrazinecarboxylate
- Purity
- 95%
- Packaging
- 500mg
- Price
- $32
- Updated
- 2021/12/16
- Product number
- 046131
- Product name
- tert-Butyl 4-(4-amino-2-fluorophenyl)tetrahydro-1(2H)-pyrazinecarboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- W3370
- Product name
- 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline
- Packaging
- 250mg
- Price
- $82
- Updated
- 2021/12/16
4-(4-Boc-piperazin-1-yl)-3-fluoroaniline Chemical Properties,Usage,Production
Synthesis
154590-34-8
154590-35-9
Preparation of 3-4-2: [3-Fluoro-4-(Boc-piperazinyl)]aniline To 150 mL of ethyl acetate were sequentially added 9.3 g (28.6 mmol) of tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate synthesized by the preparation of Example 3-4-1 and 930 mg (10 wt%) of Pd/C catalyst. The mixture was placed in a hydrogen reactor and reacted at 4 bar hydrogen pressure for 6 hours. Upon completion of the reaction, the Pd/C catalyst was removed by filtration. The filtrate was concentrated by distillation under reduced pressure and subsequently dried under vacuum at about 40 °C to give 8.22 g (yield: 97%) of the title compound. Mass spectrum (M + H)+: 296.11 1H-NMR (DMSO-d6) δ: 1.42 (s, 9H), 2.76 (br m, 4H), 3.43 (br m, 4H), 5.02 (s, 2H), 6.33 (m, 2H), 6.79 (m, 1H).
References
[1] Patent: US2011/306606, 2011, A1. Location in patent: Page/Page column 15
[2] Patent: EP2394993, 2011, A2. Location in patent: Page/Page column 23
[3] Patent: WO2005/82892, 2005, A2. Location in patent: Page/Page column 62-63
[4] Patent: WO2004/18439, 2004, A1. Location in patent: Page 31
[5] Patent: US2007/100141, 2007, A1. Location in patent: Page/Page column 27
4-(4-Boc-piperazin-1-yl)-3-fluoroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline manufacturers
- Product
- 4-(4-Boc-piperazin-1-yl)-3-fluoroaniline 154590-35-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-17