(S)-3-aminopiperidin-2-one Hydrochloride
- Product Name
- (S)-3-aminopiperidin-2-one Hydrochloride
- CAS No.
- 42538-31-8
- Chemical Name
- (S)-3-aminopiperidin-2-one Hydrochloride
- Synonyms
- Ornithine aspartate-1;Aspartic acid Impurity B;Ornithine-1,5-LactaM HCl;3-(S)-Amino-piperidin-2-one L-Ornithine lactam (hydrochloride);(S)-3-AMino-2-piperidone Hydrochloride;(S)-3-aminopiperidin-2-one Hydrochloride;3-(S)-AMINO-PIPERIDIN-2-ONE HYDROCHLORIDE;(3S)-3-Amino-2-piperidinone Hydrochloride;(S)-3-AMino-2-piperidone hydrochloride 95%
- CBNumber
- CB21562273
- Molecular Formula
- C5H11ClN2O
- Formula Weight
- 150.61
- MOL File
- 42538-31-8.mol
(S)-3-aminopiperidin-2-one Hydrochloride Property
- Melting point:
- 180-203°C (decomposition)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 757993
- Product name
- (S)-3-Amino-2-piperidone hydrochloride
- Purity
- 95%
- Packaging
- 500mg
- Price
- $80.1
- Updated
- 2022/05/15
- Product number
- A627940
- Product name
- (S)-3-Aminopiperidin-2-oneHydrochloride
- Packaging
- 50mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- A627940
- Product name
- (S)-3-Aminopiperidin-2-oneHydrochloride
- Packaging
- 2.5g
- Price
- $845
- Updated
- 2021/12/16
- Product number
- 5871AB
- Product name
- (S)-3-Aminopiperidin-2-onehydrochloride
- Packaging
- 250mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- 132433
- Product name
- (S)-3-Aminopiperidin-2-onehydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $139
- Updated
- 2021/12/16
(S)-3-aminopiperidin-2-one Hydrochloride Chemical Properties,Usage,Production
Uses
(S)-3-Amino-2-piperidone hydrochloride can be used as a building block for the synthesis of 5-hydroxy-2-[(3S)-2-oxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione by reacting with 4-hydroxyphthalic anhydride. It is also used to prepare eukaryotic signaling peptide glorin and its synthetic analog glorinamide.
Synthesis
3184-13-2
42538-31-8
General procedure for the synthesis of 3-(S)-amino-2-piperidone hydrochloride from L-ornithine hydrochloride: trimethylchlorosilane (2.8 mL, 23 mmol, 4 eq.) was slowly added to L-ornithine hydrochloride (1.0 g, 6.0 mmol, 1 eq.), followed by anhydrous methanol (20 mL). The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the solution was cooled to 0 °C and an ethanol solution of 21% (w/w) sodium ethanol (42 mmol, 17 mL) was added dropwise. after 5 min, the reaction system was slowly warmed up to room temperature and stirring was continued for 30 min. The pH of the reaction solution was adjusted with aqueous 6N HCl to 7. The neutralized solution was filtered and the filtrate was concentrated under reduced pressure. The crude product was concentrated again under reduced pressure to remove salts by dissolving in isopropanol and filtering to remove insoluble matter. Finally, the crude product was purified by silica gel fast column chromatography (eluent: 30% methanol/dichloromethane) to afford the target compound 3-(S)-amino-2-piperidone hydrochloride as a hygroscopic light yellow solid.
References
[1] Beilstein Journal of Organic Chemistry, 2017, vol. 13, p. 247 - 250
[2] Enantiomer, 2001, vol. 6, # 5, p. 275 - 279
[3] Chemistry Letters, 1981, p. 1691 - 1694
[4] Organic Process Research and Development, 2005, vol. 9, # 5, p. 570 - 576
(S)-3-aminopiperidin-2-one Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-3-aminopiperidin-2-one Hydrochloride Suppliers
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 7247
- Advantage
- 62
- Tel
- 15928766785 15928766785
- Fax
- QQ961458712
- wupengcheng@astatech.cn
- Country
- China
- ProdList
- 1987
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 031185291771 13832391721
- Fax
- 0311-67305698
- yaofeng2005@163.com
- Country
- China
- ProdList
- 978
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 20-66003216 18666003216
- Fax
- +86-20-28069063
- info@porsefinechemical.com
- Country
- China
- ProdList
- 1941
- Advantage
- 62
- Tel
- 0513-85921823 18662920231
- Fax
- 86-513-85012876
- sales@ntminyanmedical.com
- Country
- China
- ProdList
- 4107
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
View Lastest Price from (S)-3-aminopiperidin-2-one Hydrochloride manufacturers
- Product
- (S)-3-aminopiperidin-2-one Hydrochloride 42538-31-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-09
- Product
- (S)-3-aminopiperidin-2-one Hydrochloride 42538-31-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- (S)-3-aminopiperidin-2-one Hydrochloride 42538-31-8
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-10