Histamine dihydrochloride
- Product Name
- Histamine dihydrochloride
- CAS No.
- 56-92-8
- Chemical Name
- Histamine dihydrochloride
- Synonyms
- HISTAMINE 2HCL;HistaMine dihdrochloride;Ceplene;Peremin;OCHLORIDE;Histamine HCI;HistaMine dihy;HISTAMINE DIHCL;histaMine (HCl)2;HistaMine Chloride
- CBNumber
- CB5183827
- Molecular Formula
- C5H11Cl2N3
- Formula Weight
- 184.07
- MOL File
- 56-92-8.mol
Histamine dihydrochloride Property
- Melting point:
- 249-252 °C(lit.)
- storage temp.
- 2-8°C
- solubility
- H2O: 0.1 g/mL, clear, colorless
- form
- powder
- color
- white to off-white
- Water Solubility
- SOLUBLE
- Merck
- 14,4719
- BRN
- 3624116
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- PPZMYIBUHIPZOS-UHFFFAOYSA-N
- CAS DataBase Reference
- 56-92-8(CAS DataBase Reference)
- EPA Substance Registry System
- 1H-Imidazole-4-ethanamine, dihydrochloride (56-92-8)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-42/43-42-22
- Safety Statements
- 22-26-36/37/39-45-37-36/37
- RIDADR
- 3335
- WGK Germany
- 2
- RTECS
- MS1575000
- F
- 1-8-9
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29332900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 53300
- Product name
- Histamine dihydrochloride
- Purity
- ≥99.0% (AT)
- Packaging
- 1g
- Price
- $20.6
- Updated
- 2024/03/01
- Product number
- 1309009
- Product name
- Histamine dihydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 250mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- H0146
- Product name
- Histamine Dihydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- H0146
- Product name
- Histamine Dihydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- L09198
- Product name
- Histamine dihydrochloride, 98+%
- Packaging
- 5g
- Price
- $55.1
- Updated
- 2024/03/01
Histamine dihydrochloride Chemical Properties,Usage,Production
Chemical Properties
white powder
Uses
Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter.
Uses
Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.
Uses
Histamine dihydrochloride has been used:
- as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)
- to determine its level in fish using HPLC (high performance liquid chromatography)
- to assess the tracheal response to antigens in guinea-pigs
General Description
Histamine Dihydrochloride is a derivative of histamine, which is implicated in tumor cell apoptosis and prevents the relapse of acute myeloid leukemia in patients. It prevents the formation of ROS (reactive oxygen species) and inhibits the activation of T cells and natural killer cells.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biological Activity
Endogenous agonist at histamine receptors (H 1-4 ). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo .
Biochem/physiol Actions
Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor.
storage
Room temperature (desiccate)
Purification Methods
The dihydrochloride crystallises from aqueous EtOH. The phosphate (2H3PO4) [51-74-1] has m 132-133o (from H2O). [Beilstein 25 III/IV 2049.]
Histamine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Histamine dihydrochloride manufacturers
- Product
- Histamine dihydrochloride 56-92-8
- Price
- US $260.00-200.00/ton
- Min. Order
- 1ton
- Purity
- 99%
- Supply Ability
- 500 ton
- Release date
- 2023-09-14
- Product
- Histamine dihydrochloride 56-92-8
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98% HPLC
- Supply Ability
- 100kg
- Release date
- 2023-08-22
- Product
- Histamine dihydrochloride 56-92-8
- Price
- US $339.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 25kg
- Release date
- 2023-11-16