ChemicalBook > CAS DataBase List > Histamine dihydrochloride

Histamine dihydrochloride

Product Name
Histamine dihydrochloride
CAS No.
56-92-8
Chemical Name
Histamine dihydrochloride
Synonyms
HISTAMINE 2HCL;HistaMine dihdrochloride;Ceplene;Peremin;OCHLORIDE;Histamine HCI;HistaMine dihy;HISTAMINE DIHCL;histaMine (HCl)2;HistaMine Chloride
CBNumber
CB5183827
Molecular Formula
C5H11Cl2N3
Formula Weight
184.07
MOL File
56-92-8.mol
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Histamine dihydrochloride Property

Melting point:
249-252 °C(lit.)
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, colorless
form 
powder
color 
white to off-white
Water Solubility 
SOLUBLE
Merck 
14,4719
BRN 
3624116
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
PPZMYIBUHIPZOS-UHFFFAOYSA-N
CAS DataBase Reference
56-92-8(CAS DataBase Reference)
EPA Substance Registry System
1H-Imidazole-4-ethanamine, dihydrochloride (56-92-8)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-42/43-42-22
Safety Statements 
22-26-36/37/39-45-37-36/37
RIDADR 
3335
WGK Germany 
2
RTECS 
MS1575000
F 
1-8-9
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29332900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
53300
Product name
Histamine dihydrochloride
Purity
≥99.0% (AT)
Packaging
1g
Price
$20.6
Updated
2024/03/01
Sigma-Aldrich
Product number
1309009
Product name
Histamine dihydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
250mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
H0146
Product name
Histamine Dihydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$15
Updated
2021/12/16
TCI Chemical
Product number
H0146
Product name
Histamine Dihydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$39
Updated
2021/12/16
Alfa Aesar
Product number
L09198
Product name
Histamine dihydrochloride, 98+%
Packaging
5g
Price
$55.1
Updated
2024/03/01
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Histamine dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter.

Uses

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.

Uses

Histamine dihydrochloride has been used:

  • as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)
  • to determine its level in fish using HPLC (high performance liquid chromatography)
  • to assess the tracheal response to antigens in guinea-pigs

General Description

Histamine Dihydrochloride is a derivative of histamine, which is implicated in tumor cell apoptosis and prevents the relapse of acute myeloid leukemia in patients. It prevents the formation of ROS (reactive oxygen species) and inhibits the activation of T cells and natural killer cells.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biological Activity

Endogenous agonist at histamine receptors (H 1-4 ). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo .

Biochem/physiol Actions

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor.

storage

Room temperature (desiccate)

Purification Methods

The dihydrochloride crystallises from aqueous EtOH. The phosphate (2H3PO4) [51-74-1] has m 132-133o (from H2O). [Beilstein 25 III/IV 2049.]

Histamine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Histamine dihydrochloride Suppliers

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View Lastest Price from Histamine dihydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Histamine dihydrochloride 56-92-8
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-06-04
Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
Histamine dihydrochloride 56-92-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1000
Release date
2024-12-26
Shanghai UCHEM Inc.
Product
Histamine dihydrochloride 56-92-8
Price
US $339.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
25kg
Release date
2023-11-16

56-92-8, Histamine dihydrochlorideRelated Search:

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