Synthesis
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L-Lysine hydrochloride

Synthesis
Product Name
L-Lysine hydrochloride
CAS No.
657-27-2
Chemical Name
L-Lysine hydrochloride
Synonyms
L-LYSINE HCL;L-LYSINE MONOHYDROCHLORIDE;LYSINE HCL;LYSINE HYDROCHLORIDE;LYSINE MONOHYDROCHLORIDE;L-Lysine HCl USP;monohydrochloride,l-lysin;L-LYS HCL;L-LYSINE HYDROCHLORIDE USP;L-2,6-Diaminohexanoic acid monohydrochloride
CBNumber
CB5180129
Molecular Formula
C6H14N2O2.ClH
Formula Weight
182.65
MOL File
657-27-2.mol
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L-Lysine hydrochloride Property

Melting point:
263 °C (dec.)(lit.)
alpha 
21 º (c=8, 6N HCl)
Density 
1.28 g/cm3 (20℃)
vapor pressure 
<1 Pa (20 °C)
FEMA 
3847 | L-LYSINE
storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL
form 
powder
color 
White to Off-white
PH
5.5-6.0 (100g/l, H2O, 20℃)
Odor
odorless
optical activity
[α]20/D +20.5±0.5°, c = 5% in 5 M HCl
Water Solubility 
65 g/100 mL (20 ºC)
λmax
λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.1
Merck 
14,5636
BRN 
3563889
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
-1.036 (est)
CAS DataBase Reference
657-27-2(CAS DataBase Reference)
EPA Substance Registry System
Lysine hydrochloride (657-27-2)
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Safety

Hazard Codes 
WGK Germany 
2
HS Code 
2922410000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.16018
Product name
(S)-(+)-Lysine monohydrochloride
Purity
for synthesis
Packaging
100g
Price
$62.9
Updated
2024/03/01
Sigma-Aldrich
Product number
8.16018
Product name
(S)-(+)-Lysine monohydrochloride
Purity
for synthesis
Packaging
500g
Price
$217
Updated
2024/03/01
Sigma-Aldrich
Product number
62929
Product name
L-Lysine monohydrochloride
Purity
BioUltra, ≥99.5% (AT)
Packaging
100g
Price
$68.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1.05701
Product name
L-Lysine monohydrochloride
Purity
EMPROVE? ESSENTIAL Ph Eur,BP,USP
Packaging
1kg
Price
$215
Updated
2024/03/01
Sigma-Aldrich
Product number
1372005
Product name
L-Lysine monohydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$519
Updated
2024/03/01
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L-Lysine hydrochloride Chemical Properties,Usage,Production

Synthesis

L-Lysine hydrochloride can be synthesisied by microbial fermentation to give crude L-Lysine , and then purified and synthesized by crystallization in hydrochloric acid.

Description

A white or nearly white, practically odorless, free-flowing, crys talline powder. It is freely soluble in water, but is almost insoluble in alcohol and in ether. It melts at about 260°C with decomposition.

Chemical Properties

White crystalline powder

Uses

amino acid, nutrient

Uses

L-(+)-Lysine Monohydrochloride

Uses

L-Lysine monohydrochloride is widely used as nutritional supplements in food and beverage industries. It can also be used in animal feed as source of L-Lysine.? L-Lysine Monohydrochloride can be used in a wide variety of industries including: food production, beverage, pharmaceutical, agriculture/animal feed, and various other industries.

Definition

ChEBI: The hydrochloride salt of L-lysine

Biochem/physiol Actions

L-lysine is an essential amino acid in animals and humans. L-Lysine is necessary for protein synthesis in the body and proper growth. L-lysine lowers the cholesterol level by producing carnitine. L-lysine aids in calcium, zinc and iron absorption. Athletes take L-lysine as a supplement for lean mass building and for proper muscle and bone health. L-lysine competes with arginine during viral replication and reduces herpes simplex virus infection. L-lysine supplementation reduces chronic anxiety in human. Lysine reduces viscosity of serum albumin solution for injections.

Safety Profile

iWdly toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Purification Methods

Likely impurities are arginine, D-lysine, 2,6-diaminoheptanedioic acid and glutamic acid. Crystallise the monohydrochloride from water at pH 4-6 by adding 4 volumes of EtOH. At above 60% relative humidity it forms a dihydrate. [Birhbaum et al. J Biol Chem 194 455, 468 1952, Kearley & Ingersoll J Am Chem Soc 73 5783 1951, Beilstein 4 IV 2717.]

L-Lysine hydrochloride Preparation Products And Raw materials

Raw materials

Acid off Ammonium hydroxide Nitrogen 2-Furoic acid D-Biotin Pimelic acid L-Glutamic acid AMBERLITE(R) IRC-50 2,3-Dihydrofuran L-Lysine Potassium Phosphate Monobasic L-Lysine hydrochloride Polyacrylamide Hydrochloric acid Caprolactam Activated carbon,decolor Activated carbon Ammonium sulfate Celite Ammonia

Preparation Products

Boc-Lys(Boc)-OH
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L-Lysine hydrochloride Suppliers

Americas 1 Belgium 1 Canada 2 China 624 Europe 4 France 5 Germany 14 Hungary 1 India 50 Japan 12 Singapore 1 Slovakia 1 Switzerland 3 United Kingdom 15 United States 84 USA 1 Global 819
Wuxi Bikang Bioengineering Co., Ltd
Tel
0510-80245888 400-0510-518
Fax
0510-80245999
Email
1258079079@qq.com
Country
China
ProdList
46
Advantage
58
Hebei Jiuxing Chemical Products Co., Ltd
Tel
13503103636 13503103636
Email
2223638087@qq.com
Country
China
ProdList
616
Advantage
58
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
3970
Advantage
60
Hebei chuangzhiyuan biotechnology co., LTD
Tel
13012111162
Email
2792365312@qq.com
Country
China
ProdList
811
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
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View Lastest Price from L-Lysine hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
L-Lysine Hydrochloride 657-27-2
Price
US $78.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-Lysine hydrochloride 657-27-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%-101.5%
Supply Ability
10 TONS
Release date
2021-06-08
Hebei ZB Gamay Biological Technology Co.,Ltd
Product
L-Lysine HCL
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
none
Supply Ability
500kg
Release date
2022-10-26

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