Synthesis
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L-Lysine hydrochloride

Synthesis
Product Name
L-Lysine hydrochloride
CAS No.
657-27-2
Chemical Name
L-Lysine hydrochloride
Synonyms
L-LYSINE HCL;L-LYSINE MONOHYDROCHLORIDE;LYSINE HCL;LYSINE HYDROCHLORIDE;LYSINE MONOHYDROCHLORIDE;L-Lysine HCl USP;monohydrochloride,l-lysin;L-LYS HCL;L-LYSINE HYDROCHLORIDE USP;L-2,6-Diaminohexanoic acid monohydrochloride
CBNumber
CB5180129
Molecular Formula
C6H14N2O2.ClH
Formula Weight
182.65
MOL File
657-27-2.mol
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L-Lysine hydrochloride Property

Melting point:
263 °C (dec.)(lit.)
alpha 
21 º (c=8, 6N HCl)
Density 
1.28 g/cm3 (20℃)
bulk density
360kg/m3
vapor pressure 
<1 Pa (20 °C)
FEMA 
3847 | L-LYSINE
storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL
form 
powder
color 
White to Off-white
Odor
odorless
PH
5.5-6.0 (100g/l, H2O, 20℃)
biological source
non-animal source
optical activity
[α]20/D +20.5±0.5°, c = 5% in 5 M HCl
Water Solubility 
65 g/100 mL (20 ºC)
λmax
λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.1
Merck 
14,5636
BRN 
3563889
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
-1.036 (est)
CAS DataBase Reference
657-27-2(CAS DataBase Reference)
EPA Substance Registry System
Lysine hydrochloride (657-27-2)
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Safety

Hazard Codes 
WGK Germany 
2
RTECS 
OL5650000
HS Code 
2922410000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W384712
Product name
<SC>L</SC>-Lysine hydrochloride
Purity
natural, FG
Packaging
1 unit
Price
$58.5
Updated
2025/07/31
Sigma-Aldrich
Product number
W384712
Product name
<SC>L</SC>-Lysine hydrochloride
Purity
natural, FG
Packaging
1 unit
Price
$58.5
Updated
2025/07/31
Sigma-Aldrich
Product number
W384712
Product name
L-Lysine hydrochloride
Purity
natural, FG
Packaging
100G
Price
$146
Updated
2025/07/31
Sigma-Aldrich
Product number
L0900000
Product name
Lysine hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
50 mg
Price
$236
Updated
2025/07/31
Sigma-Aldrich
Product number
8.16018
Product name
(S)-(+)-Lysine monohydrochloride
Purity
for synthesis
Packaging
100g
Price
$54.2
Updated
2025/07/31
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L-Lysine hydrochloride Chemical Properties,Usage,Production

Synthesis

L-Lysine hydrochloride can be synthesisied by microbial fermentation to give crude L-Lysine , and then purified and synthesized by crystallization in hydrochloric acid.

Description

L-Lysine hydrochloride is a white or nearly white, practically odorless, free-flowing, crys talline powder. It is freely soluble in water, but is almost insoluble in alcohol and in ether. It melts at about 260°C with decomposition.

Chemical Properties

White crystalline powder

Uses

L-Lysine hydrochloride is widely used as nutritional supplements in food and beverage industries. It can also be used in animal feed as source of L-Lysine. It can be used in a wide variety of industries including: food production, beverage, pharmaceutical, agriculture/animal feed, and various other industries.

Definition

ChEBI: The hydrochloride salt of L-lysine

Biochem/physiol Actions

L-lysine is an essential amino acid in animals and humans. L-Lysine is necessary for protein synthesis in the body and proper growth. L-lysine lowers the cholesterol level by producing carnitine. L-lysine aids in calcium, zinc and iron absorption. Athletes take L-lysine as a supplement for lean mass building and for proper muscle and bone health. L-lysine competes with arginine during viral replication and reduces herpes simplex virus infection. L-lysine supplementation reduces chronic anxiety in human. Lysine reduces viscosity of serum albumin solution for injections.

Side effects

L-Lysine hydrochloride may cause side effects such as stomach pain and diarrhea.

Safety Profile

L-Lysine hydrochloride is hazardous by inhalation. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Purification Methods

Likely impurities are arginine, D-lysine, 2,6-diaminoheptanedioic acid and glutamic acid. Crystallise the monohydrochloride from water at pH 4-6 by adding 4 volumes of EtOH. At above 60% relative humidity it forms a dihydrate. [Birhbaum et al. J Biol Chem 194 455, 468 1952, Kearley & Ingersoll J Am Chem Soc 73 5783 1951, Beilstein 4 IV 2717.]

L-Lysine hydrochloride Preparation Products And Raw materials

Raw materials

Acid off Ammonium hydroxide Nitrogen 2-Furoic acid D-Biotin Pimelic acid L-Glutamic acid AMBERLITE(R) IRC-50 2,3-Dihydrofuran L-Lysine Potassium Phosphate Monobasic L-Lysine hydrochloride Polyacrylamide Hydrochloric acid Caprolactam Activated carbon,decolor Activated carbon Ammonium sulfate Celite Ammonia

Preparation Products

Boc-Lys(Boc)-OH
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L-Lysine hydrochloride Suppliers

Americas 1 Belgium 1 Canada 2 China 743 Europe 4 France 5 Germany 14 Hungary 1 India 48 Japan 12 Singapore 1 Slovakia 1 Switzerland 3 United Kingdom 15 United States 84 USA 1 Global 936
Clearsynth Labs Limited
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View Lastest Price from L-Lysine hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
L-Lysine hydrochloride 657-27-2
Price
US $1.00-4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2025-09-12
Lianyungang Kaiyu Environmental Tech Co., Ltd.
Product
L-Lysine HCL 657-27-2
Price
US $0.00-0.00/kgs
Min. Order
25kgs
Purity
≥99.0%
Supply Ability
100 tons
Release date
2025-06-19
Lianyungang Kaiyu Environmental Tech Co., Ltd.
Product
L-Lysine HCL 657-27-2
Price
US $0.00-0.00/kgs
Min. Order
25kgs
Purity
≥99.0%
Supply Ability
100 tons
Release date
2025-06-19

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