Synthesis
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L-Lysine hydrochloride

Synthesis
Product Name
L-Lysine hydrochloride
CAS No.
657-27-2
Chemical Name
L-Lysine hydrochloride
Synonyms
L-LYSINE HCL;L-LYSINE MONOHYDROCHLORIDE;LYSINE HCL;LYSINE HYDROCHLORIDE;LYSINE MONOHYDROCHLORIDE;L-Lysine HCl USP;monohydrochloride,l-lysin;L-LYS HCL;L-LYSINE HYDROCHLORIDE USP;L-2,6-Diaminohexanoic acid monohydrochloride
CBNumber
CB5180129
Molecular Formula
C6H14N2O2.ClH
Formula Weight
182.65
MOL File
657-27-2.mol
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L-Lysine hydrochloride Property

Melting point:
263 °C (dec.)(lit.)
alpha 
21 º (c=8, 6N HCl)
Density 
1.28 g/cm3 (20℃)
vapor pressure 
<1 Pa (20 °C)
FEMA 
3847 | L-LYSINE
storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL
form 
powder
color 
White to Off-white
PH
5.5-6.0 (100g/l, H2O, 20℃)
Odor
odorless
optical activity
[α]20/D +20.5±0.5°, c = 5% in 5 M HCl
Water Solubility 
65 g/100 mL (20 ºC)
λmax
λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.1
Merck 
14,5636
BRN 
3563889
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
-1.036 (est)
CAS DataBase Reference
657-27-2(CAS DataBase Reference)
EPA Substance Registry System
Lysine hydrochloride (657-27-2)
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Safety

Hazard Codes 
WGK Germany 
2
HS Code 
2922410000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.16018
Product name
(S)-(+)-Lysine monohydrochloride
Purity
for synthesis
Packaging
100g
Price
$62.9
Updated
2024/03/01
Sigma-Aldrich
Product number
8.16018
Product name
(S)-(+)-Lysine monohydrochloride
Purity
for synthesis
Packaging
500g
Price
$217
Updated
2024/03/01
Sigma-Aldrich
Product number
62929
Product name
L-Lysine monohydrochloride
Purity
BioUltra, ≥99.5% (AT)
Packaging
100g
Price
$68.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1.05701
Product name
L-Lysine monohydrochloride
Purity
EMPROVE? ESSENTIAL Ph Eur,BP,USP
Packaging
1kg
Price
$215
Updated
2024/03/01
Sigma-Aldrich
Product number
1372005
Product name
L-Lysine monohydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$519
Updated
2024/03/01
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L-Lysine hydrochloride Chemical Properties,Usage,Production

Synthesis

L-Lysine hydrochloride can be synthesisied by microbial fermentation to give crude L-Lysine , and then purified and synthesized by crystallization in hydrochloric acid.

Description

A white or nearly white, practically odorless, free-flowing, crys talline powder. It is freely soluble in water, but is almost insoluble in alcohol and in ether. It melts at about 260°C with decomposition.

Chemical Properties

White crystalline powder

Uses

amino acid, nutrient

Uses

L-(+)-Lysine Monohydrochloride

Uses

L-Lysine monohydrochloride is widely used as nutritional supplements in food and beverage industries. It can also be used in animal feed as source of L-Lysine.? L-Lysine Monohydrochloride can be used in a wide variety of industries including: food production, beverage, pharmaceutical, agriculture/animal feed, and various other industries.

Definition

ChEBI: The hydrochloride salt of L-lysine

Biochem/physiol Actions

L-lysine is an essential amino acid in animals and humans. L-Lysine is necessary for protein synthesis in the body and proper growth. L-lysine lowers the cholesterol level by producing carnitine. L-lysine aids in calcium, zinc and iron absorption. Athletes take L-lysine as a supplement for lean mass building and for proper muscle and bone health. L-lysine competes with arginine during viral replication and reduces herpes simplex virus infection. L-lysine supplementation reduces chronic anxiety in human. Lysine reduces viscosity of serum albumin solution for injections.

Safety Profile

iWdly toxic by ingestion. When heated to decomposition it emits very toxic fumes of HCl and NOx.

Purification Methods

Likely impurities are arginine, D-lysine, 2,6-diaminoheptanedioic acid and glutamic acid. Crystallise the monohydrochloride from water at pH 4-6 by adding 4 volumes of EtOH. At above 60% relative humidity it forms a dihydrate. [Birhbaum et al. J Biol Chem 194 455, 468 1952, Kearley & Ingersoll J Am Chem Soc 73 5783 1951, Beilstein 4 IV 2717.]

L-Lysine hydrochloride Preparation Products And Raw materials

Raw materials

Acid off Ammonium hydroxide Nitrogen 2-Furoic acid D-Biotin Pimelic acid L-Glutamic acid AMBERLITE(R) IRC-50 2,3-Dihydrofuran L-Lysine Potassium Phosphate Monobasic L-Lysine hydrochloride Polyacrylamide Hydrochloric acid Caprolactam Activated carbon,decolor Activated carbon Ammonium sulfate Celite Ammonia

Preparation Products

Boc-Lys(Boc)-OH
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L-Lysine hydrochloride Suppliers

Americas 1 Belgium 1 Canada 2 China 623 Europe 4 France 5 Germany 14 Hungary 1 India 50 Japan 12 Singapore 1 Slovakia 1 Switzerland 3 United Kingdom 15 United States 84 USA 1 Global 818
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
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Japan
ProdList
28387
Advantage
80
KYOWA HAKKO BIO CO., LTD.
Tel
--
Fax
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Japan
ProdList
33
Advantage
58
Ajinomoto Co., Inc
Tel
--
Fax
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Email
info@ajinomoto.com.
Country
Japan
ProdList
19
Advantage
58
AJINOMOTO CO INC
Tel
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Country
Japan
ProdList
12
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58
Watanabe Chemical Industries, Ltd.
Tel
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Email
inquiry@watanabechem.co.jp
Country
Japan
ProdList
1918
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50
Junsei Chemical Co., Ltd.
Tel
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Email
shiyaku@junsei.co.jp
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Japan
ProdList
3096
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46
Peptide Institute, Inc.
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Email
info@peptide.co.jp
Country
Japan
ProdList
992
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70
Nacalai Tesque, Inc.
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Email
info-tech@nacalai.co.jp
Country
Japan
ProdList
6046
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75
Kokusan Chemical Co., Ltd.
Tel
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tech@kokusan-chem.co.jp
Country
Japan
ProdList
1658
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51
Watanabe Chemical Industries, Ltd.
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Japan
ProdList
4811
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Kanto Chemical Co., Inc.
Tel
--
Fax
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Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
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74
Wako Pure Chemical Industries, Ltd.
Tel
--
Fax
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Email
labchem-tec@wako-chem.co.jp
Country
Japan
ProdList
6819
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80
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View Lastest Price from L-Lysine hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
L-Lysine Hydrochloride 657-27-2
Price
US $78.00-35.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-20
WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-Lysine hydrochloride 657-27-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%-101.5%
Supply Ability
10 TONS
Release date
2021-06-08
Hebei Miaoyin Technology Co.,Ltd
Product
L-Lysine Hydrochloride 657-27-2
Price
US $20.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000
Release date
2023-04-06

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