ZONISAMIDE-13C2-15N

Product Name: ZONISAMIDE-13C2-15N
CAS No.: 1188265-58-8
Chemical Name: ZONISAMIDE-13C2-15N
Synonyms: ZONISAMIDE-13C2-15N;13C2,15N]-Zonisamide
CBNumber: CB2156257
Molecular Formula: C8H8N2O3S
Formula Weight: 215.25
MOL File: Mol file

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ZONISAMIDE-13C2-15N Property

Melting point:: 158 - 160°C
storage temp.: Refrigerator
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Solid
color: Off-White to Light Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28807
Product name: Zonisamide-13C2,15N
Packaging: 1mg
Price: $396
Updated: 2024/03/01

TRC

Product number: Z700003
Product name: Zonisamide-13C2-15N
Packaging: 10mg
Price: $1980
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: CN17154
Product name: Zonisamide-13C2,15N
Packaging: 5mg
Price: $2900
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: CN100165
Product name: Zonisamid2-15C2-15N
Packaging: 1mg
Price: $475
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: CN17154
Product name: Zonisamide-13C2,15N
Packaging: 1mg
Price: $1750
Updated: 2021/12/16

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ZONISAMIDE-13C2-15N Chemical Properties,Usage,Production

Description

Zonisamide-¹³C₂,¹⁵N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent. It selectively inhibits the repeated firing of sodium channels (IC₅₀ = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml. In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium current. Zonisamide inhibits H. pylori recombinant carbonic anhydrase (CA) and the human CA isoforms I, II, and V with K_i values of 218, 56, 35, and 21 nM, respectively. In mice, it has anticonvulsant activity against maximal electroshock seizure (MES) and pentylenetetrazole-induced maximal, but not minimal, seizures (ED₅₀s = 19.6, 9.3, and >500 mg/kg, respectively). Zonisamide (40 mg/kg, p.o.) prevents MPTP-induced decreases in the levels of dopamine , but not homovanillic acid (HVA; ) or dihydroxyphenyl acetic acid (DOPAC; ), and increases MPTP-induced decreases in the dopamine turnover rate in mouse striatum in a model of Parkinson''s disease. Formulations containing zonisamide have been used in the treatment of partial seizures in adults with epilepsy.

Uses

Zonisamide-13C2-15N is the labeled analogue of Zonisamide (Z700000), a sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Heterocyclic methanesulfonide with anticonvulsant properties. The compound is under investigation for potential therapeutic use as an antiepileptic drug. Anticonvulsant.

References

[1] YOSHINOBU MASUDA Masanao S Masayuki Ishizaki. Zonisamide: Pharmacology and Clinical Efficacy in Epilepsy[J]. CNS drug reviews, 2006, 4 4: 341-360. DOI: 10.1111/j.1527-3458.1998.tb00075.x
[2] DAVID M ROCK Charles P T Robert L Macdonald. Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant[J]. Epilepsy Research, 1989, 3 2: Pages 138-143. DOI: 10.1016/0920-1211(89)90041-7
[3] SETSUO SUZUKI. Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex[J]. Epilepsy Research, 1992, 12 1: Pages 21-27. DOI: 10.1016/0920-1211(92)90087-a
[4] ISAO NISHIMORI . Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies of a carboxyterminal truncated α-carbonic anhydrase from Helicobacter pylori[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16 8: Pages 2182-2188. DOI: 10.1016/j.bmcl.2006.01.044
[5] GIUSEPPINA DE SIMONE . Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies[J]. Bioorganic & Medicinal Chemistry Letters, 2005, 15 9: Pages 2315-2320. DOI: 10.1016/j.bmcl.2005.03.032
[6] HAYATO YABE . Zonisamide Increases Dopamine Turnover in the Striatum of Mice and Common Marmosets Treated With MPTP[J]. Journal of pharmacological sciences, 2009, 110 1: Pages 64-68. DOI: 10.1254/jphs.09019fp

ZONISAMIDE-13C2-15N Preparation Products And Raw materials

Raw materials

Preparation Products

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ZONISAMIDE-13C2-15N Suppliers

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1188265-58-8, ZONISAMIDE-13C2-15NRelated Search:

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ZONISAMIDE-13C2-15N

13C2,15N]-Zonisamide

1188265-58-8