H-1152Glycyl, Dihydrochloride
- Product Name
- H-1152Glycyl, Dihydrochloride
- CAS No.
- 913844-45-8
- Chemical Name
- H-1152Glycyl, Dihydrochloride
- Synonyms
- Glycyl-H 1152 2HCl;Rho Kinase Inhibitor IV;Glycyl H-1152 hydrochloride;H-1152Glycyl, Dihydrochloride;(S)-Glycyl-H-1152 (hydrochloride);Glycyl H1152 hydrochloride,Glycyl H 1152 hydrochloride;(S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl) sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride;(2S)-4-(Aminoacetyl)hexahydro -2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine Dihydrochloride;2-Amino-1-[(3S)-hexahydro-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepin-1-yl]ethanone Hydrochloride
- CBNumber
- CB21564868
- Molecular Formula
- C18H26Cl2N4O3S
- Formula Weight
- 0
- MOL File
- 913844-45-8.mol
H-1152Glycyl, Dihydrochloride Property
- Melting point:
- 190-192°C
- storage temp.
- Refrigerator
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- Pale Yellow to Beige
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 913844-45-8
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H370Causes damage to organs
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P307+P311IF exposed: call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 13332
- Product name
- (S)-Glycyl-H-1152 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 13332
- Product name
- (S)-Glycyl-H-1152 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 13332
- Product name
- (S)-Glycyl-H-1152 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $728
- Updated
- 2024/03/01
- Product number
- 13332
- Product name
- (S)-Glycyl-H-1152 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $1274
- Updated
- 2024/03/01
- Product number
- 013030
- Product name
- H-1152 Glycyl Dihydrochloride
- Packaging
- 1mg
- Price
- $460
- Updated
- 2021/12/16
H-1152Glycyl, Dihydrochloride Chemical Properties,Usage,Production
Chemical Properties
Pale-Yellow Solid
Uses
A glycyl analog of Rho-kinase (ROCK) inhibitor that inhibits ROCK with an improved selectitity; for treatment of hypertension and arteriosclerosis.
Biological Activity
Glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride ((S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride ) that displays improved ROCKII selectivity. IC 50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μ M for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.
storage
room temperature (desiccate)