4-bromo-1-methylpyrazole-3-carboxy acid
- Product Name
- 4-bromo-1-methylpyrazole-3-carboxy acid
- CAS No.
- 84547-84-2
- Chemical Name
- 4-bromo-1-methylpyrazole-3-carboxy acid
- Synonyms
- 4-bromo-1-methylpyrazole-3-carboxy acid;1-Methyl-4-bromopyrazole-5-carboxylic acid;4-bromo-2-methyl-3-pyrazolecarboxylic acid;4-Bromo-2-methylpyrazole-3-carboxylic acid;4-Bromo-1-methylpyrazole-5-carboxylic Acid;1H-Pyrazole-5-carboxylic acid, 4-bromo-1-methyl-;4-bromo-1-methyl-1H-pyrazole-5-carboxylic acid(SALTDATA: FREE)
- CBNumber
- CB21569904
- Molecular Formula
- C5H5BrN2O2
- Formula Weight
- 205.01
- MOL File
- 84547-84-2.mol
4-bromo-1-methylpyrazole-3-carboxy acid Property
- Melting point:
- 235-236 °C
- Boiling point:
- 347.4±27.0 °C(Predicted)
- Density
- 1.93±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 1.75±0.37(Predicted)
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- R432725
- Product name
- 4-BROMO-2-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- R432725
- Product name
- 4-BROMO-2-METHYL-2H-PYRAZOLE-3-CARBOXYLIC ACID
- Purity
- AldrichCPR
- Packaging
- 5MG
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- B697568
- Product name
- 4-Bromo-2-methylpyrazole-3-carboxylicacid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB116123
- Product name
- 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- FB116123
- Product name
- 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
4-bromo-1-methylpyrazole-3-carboxy acid Chemical Properties,Usage,Production
Synthesis
15803-02-8
124-38-9
84547-84-2
1. 600 ml of anhydrous THF was added to a 2L reaction flask under argon protection. 2. 65.4 g of diisopropylamine was added and the reaction system was subsequently cooled to -78 °C via a dry ice acetone bath. 3. 258 ml of 2.5 M n-butyllithium solution was slowly added dropwise at 0 °C. After the dropwise addition, the reaction temperature was raised to 0 °C and maintained for 0.5 h. The reaction system was then cooled to -78 °C again. 4. 80.0 g of 1-methyl-4-bromopyrazole was slowly added dropwise at -78 °C, and after the dropwise addition was completed, the reaction temperature was maintained at -78 °C for 1 hour. 5. dry carbon dioxide gas was passed into the reaction system until TLC detection showed that the reaction was complete. 6. The pH of the reaction solution was slowly adjusted to 2-3 with 1N HCl, at which time a large amount of white solid was precipitated. 7. The reaction mixture was cooled at 0 °C for 3 h, followed by filtration to collect the white solid. 8. The resulting solid was dried at 40 °C for 16 h to give 77.3 g of white solid compound 22 (4-bromo-1-methyl-1H-pyrazole-5-carboxylic acid).
References
[1] Patent: CN108264520, 2018, A. Location in patent: Paragraph 0261; 0262; 0263; 0264; 0265
4-bromo-1-methylpyrazole-3-carboxy acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-bromo-1-methylpyrazole-3-carboxy acid Suppliers
- Tel
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- sales@carbosynth.com
- Country
- United Kingdom
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- 6005
- Advantage
- 58
- Tel
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- enquiries@fluorochem.co.uk
- Country
- United Kingdom
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View Lastest Price from 4-bromo-1-methylpyrazole-3-carboxy acid manufacturers
- Product
- 4-bromo-1-methylpyrazole-3-carboxy acid 84547-84-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2019-05-24