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Boldine

Product Name
Boldine
CAS No.
476-70-0
Chemical Name
Boldine
Synonyms
boldin;(s)-yl;BOLDINE;BOLDINE(RG);(s)-boldine;Boldine CRS;(+)-boldine;(+)-(s)-boldine;ex Peumus boldus;boldine--chloroform
CBNumber
CB2167570
Molecular Formula
C19H21NO4
Formula Weight
327.37
MOL File
476-70-0.mol
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Boldine Property

Melting point:
162-164 °C
Boiling point:
465.27°C (rough estimate)
Density 
1.2223 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
2-8°C
solubility 
Acetonitrile (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
form 
Solid
pka
9.75±0.20(Predicted)
color 
Yellow to Dark Brown
Merck 
13,1316
BRN 
94036
LogP
0.837 (est)
CAS DataBase Reference
476-70-0(CAS DataBase Reference)
EPA Substance Registry System
4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6aS)- (476-70-0)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
1-20-24/25-45-36-26
RIDADR 
1544
WGK Germany 
3
RTECS 
CE0750000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0002060
Product name
Boldine for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
20 mg
Price
$118
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0000434
Product name
Boldine
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
30 mg
Price
$156
Updated
2025/07/31
Sigma-Aldrich
Product number
B3916
Product name
Boldine
Purity
analytical standard
Packaging
1g
Price
$21.7
Updated
2022/05/15
Cayman Chemical
Product number
18447
Product name
Boldine
Purity
≥95%
Packaging
1g
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
18447
Product name
Boldine
Purity
≥95%
Packaging
5g
Price
$94
Updated
2024/03/01
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Boldine Chemical Properties,Usage,Production

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Linderae odorata.

Uses

antineoplastic

Uses

boldine is attributed with strong anti-oxidant properties. It has also demonstrated an ability to protect against uVB rays. Boldine is a constituent of the boldo plant (Peumus boldus Mol.) native to Chile, and is found in the plant’s leaves and bark.

Definition

ChEBI: Boldine is an aporphine alkaloid.

in vivo

Boldine (50 mg/kg, p.o, for 7 days) attenuates Dextran Sulfate Sodium (DSS) -induced colitis in mice via p65-NF-κB and STAT3 signaling pathways[3].

Animal Model:DSS-induced mice model[3]
Dosage:50 mg/kg
Administration:p.o.
Result: Reduced the expression of CD 68+ and activity of myeloperoxidase (MPO)
Attenuated Pro-Inflammatory Cytokines and the level of malondialdehyde (MDA)
Increased the Activities of Enzymic Antioxidants and Inhibited p65-NF-κB and STAT3 Activity.

Boldine Preparation Products And Raw materials

Raw materials

Preparation Products

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Boldine Suppliers

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View Lastest Price from Boldine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Boldine 476-70-0
Price
US $1.00-45.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
420000KG
Release date
2024-08-05
Career Henan Chemical Co
Product
Boldine 476-70-0
Price
US $1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

476-70-0, BoldineRelated Search:

LINDERANE LAUROLITSINE Linderene acetate Pyruvic acid Methylparaben Colchicine (-)-Huperzine A Sophoridine BOLDINE HYDROCHLORIDE(RG),BOLDINE HYDROCHLORIDE BOLDINE DIMETHYL ETHER 4H-Dibenzo(de,g)quinolin-9-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6 -methyl-, (S)- Thalicarpine L-DICENTRINE DIACETYL BOLDINE Boldine BOLDOSTANDARDEXTRACT,0.2%BOLDINE BoldoS.E.0.05%Boldine,PeumusBoldus AKOS 208-03

  • (+)-(s)-boldine
  • (s)-boldine
  • (s)-yl
  • 1,10-dimethoxy-6a-alpha-aporphine-2,9-diol
  • 1,10-dimethoxy-6a-alpha-aporphine-9-diol
  • 4h-dibenzo(de,g)quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-meth
  • 4h-dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl
  • boldin
  • boldine--chloroform
  • BOLDINE(RG)
  • BOLDINE
  • BOLDO STANDARD EXTRACT
  • 2 6-DIHYDROXY-3 5-DIMETHOXYAPORPHIN
  • 2,9-DIHYDROXY-1,10-DIMETHOXYAPORPHINE
  • 1,10-DIMETHOXY-2,9-DIHYDROXYAPORPHINE
  • 2,9-Dihydroxy-1,10-dimethoxyaporphine, Boldine
  • (-)-6-Methyl-1,10-dimethoxy-5,6,6aα,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
  • (6aS)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol
  • 4H-Dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-diMethoxy-6-Methyl-, (6aS)-
  • Boldine CRS
  • ex Peumus boldus
  • (6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
  • (+)-boldine
  • (S)-1,10-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
  • *Tramadol Impurity 25
  • 476-70-0
  • C19H21NO4
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