TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE

Product Name: TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE
CAS No.: 723286-80-4
Chemical Name: TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE
Synonyms: 7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine;tert-butyl 3-broMo-5;3-a]pyrazine-7(8H)-carboxylate;7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-;7-Boc-3-bromo-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine;3-Bromo-7-Boc-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine;tert-butyl 3-bromo-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine...;7-N-Boc-3-Bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine;3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate;tert-butyl 3-broMo-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate
CBNumber: CB2168274
Molecular Formula: C10H15BrN4O2
Formula Weight: 303.16
MOL File: 723286-80-4.mol

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TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE Property

Boiling point:: 430.4±55.0 °C(Predicted)
Density: 1.62±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.55±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22-20/22
Safety Statements: 36/37
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B694725
Product name: tert-Butyl3-Bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
Packaging: 500mg
Price: $175
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-7V
Product name: 7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine
Packaging: 1g
Price: $186
Updated: 2021/12/16

Matrix Scientific

Product number: 069922
Product name: tert-Butyl 3-Bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
Purity: >95%
Packaging: 1g
Price: $1305
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0029985
Product name: TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $2012.01
Updated: 2021/12/16

Matrix Scientific

Product number: 069922
Product name: tert-Butyl 3-Bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate
Purity: >95%
Packaging: 5g
Price: $3839
Updated: 2021/12/16

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TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

723286-79-1

723286-80-4

The general procedure for the synthesis of 7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine using 7-Boc-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine as a starting material was as follows: 7-Boc-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine (1 g ) was dissolved in chloroform (20 mL) and sodium bicarbonate (688 mg) and N-bromosuccinimide (873 mg) were added sequentially at 0 °C in an ice bath. The reaction mixture was stirred at 0 °C for 2 hours. Upon completion of the reaction, the reaction solution was brought back to room temperature and the reaction was quenched by the addition of an appropriate amount of water, followed by three extractions with chloroform. The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography to afford the target compound 7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine (693 mg, 51% yield). lRMS (ESI) m/z 303 [M+H]+.

References

[1] Patent: JP5851663, 2016, B1. Location in patent: Paragraph 0303
[2] Patent: WO2004/58266, 2004, A1. Location in patent: Page/Page column 80

TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE Suppliers

China 106 Germany 1 India 1 United Kingdom 3 United States 14 Global 125

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

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View Lastest Price from TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE 723286-80-4
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g； 1kg; 25kg
Release date: 2020-01-10

Career Henan Chemical Co

Product: TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE 723286-80-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-26

723286-80-4, TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATERelated Search:

TERT-BUTYL 3-BROMO-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZINE-7(8H)-CARBOXYLATE TERT-BUTYL FORMATE 5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE HYDROCHLORIDE 5,6-DIHYDRO-8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE 3-bromo-4-methyl-1,2,4-triazole

TERT-BUTYL 3-BROMO-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-CARBOXYLATE

1,2,4-Triazolo[4,3-a]pyrazine-7(8H)-carboxylic acid, 3-bromo-5,6-dihydro-, 1,1-dimethylethyl ester

Tert-butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8h)-carboxylate ,97%

7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine

3-Bromo-7-Boc-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

7-Boc-3-bromo-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine

3-a]pyrazine-7(8H)-carboxylate

tert-butyl 3-broMo-5

3-BroMo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylic acid tert-butyl ester

7-N-Boc-3-Bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine

tert-butyl 3-broMo-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate

3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate

tert-butyl 3-bromo-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine...

7-Boc-3-bromo-5,6,7,8-tetrahydro-1,2,4-

1,1-Dimethylethyl 3-bromo-5,6-dihydro-1,2,4-triazolo[4,3-a]pyrazine-7(8H)-carboxylate

tert-Butyl 3-bromo-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylat

723286-80-4

C10H15BrN4O2

CHIRAL CHEMICALS