6-CHLOROCHROMAN-4-ONE
- Product Name
- 6-CHLOROCHROMAN-4-ONE
- CAS No.
- 37674-72-9
- Chemical Name
- 6-CHLOROCHROMAN-4-ONE
- Synonyms
- 6-chloro-2,3-dihydrochroMen-4-one;6-Chloro-4-chrom;BUTTPARK 35\07-32;6-CHLOROCHROMANONE;TIMTEC-BB SBB003732;6-CHLORO-4-CHROMANONE;6-CHLOROCHROMAN-4-ONE;6-Chloro-4-chromanone-1;6-Chloro-4-chroManone 97%;6-Chloro-4-chromanone >
- CBNumber
- CB2168890
- Molecular Formula
- C9H7ClO2
- Formula Weight
- 182.6
- MOL File
- 37674-72-9.mol
6-CHLOROCHROMAN-4-ONE Property
- Melting point:
- 97-102 °C(lit.)
- Boiling point:
- 322.0±42.0 °C(Predicted)
- Density
- 1.345±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in solvents.
- form
- powder to crystal
- color
- White to Yellow to Orange
- BRN
- 124218
- InChIKey
- LLTDYHFVIVSQPJ-UHFFFAOYSA-N
- CAS DataBase Reference
- 37674-72-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38-20/21/22
- Safety Statements
- 26-36-24/25
- WGK Germany
- 2
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 640476
- Product name
- 6-Chloro-4-chromanone
- Purity
- 97%
- Packaging
- 1g
- Price
- $69.3
- Updated
- 2023/06/20
- Product number
- 640476
- Product name
- 6-Chloro-4-chromanone
- Purity
- 97%
- Packaging
- 5g
- Price
- $163
- Updated
- 2023/06/20
- Product number
- C1968
- Product name
- 6-Chloro-4-chromanone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $81
- Updated
- 2025/07/31
- Product number
- C1968
- Product name
- 6-Chloro-4-chromanone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $243
- Updated
- 2025/07/31
- Product number
- C428873
- Product name
- 6-Chlorochroman-4-one
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
6-CHLOROCHROMAN-4-ONE Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
6-Chlorochroman-4-one is used as chemical, organic intermediates for pharmaceuticals.
Synthesis
3284-79-5
37674-72-9
General procedure for the synthesis of 6-chlorobenzodihydropyran-4-one from 3-(p-chlorophenoxy)propionic acid: 3-(p-chlorophenoxy)propionic acid (2 g, 10 mmol) was reacted with concentrated sulfuric acid (20 mL) with stirring for 1 hour at room temperature. After completion of the reaction, the mixture was poured into ice water and extracted with ethyl acetate. The organic layer was washed twice with saturated aqueous sodium bicarbonate and subsequently dried with magnesium sulfate. The dried organic phase was filtered and concentrated under reduced pressure. The crude product was purified by solvent recrystallization from ethyl acetate/hexane (1:5) mixture. The resulting crystals were collected by filtration, washed with hexane and dried to give the target product 6-chlorobenzodihydropyran-4-one (1 g, 55% yield): melting point 98-101 °C (literature value: 100-101 °C); 1H NMR (DMSO-d6) δ 2.82 (t, J=6.5 Hz, 2H, 3-H2), 4.56 (t, J=6.5 Hz, 2H, 2 -H2), 7.1 (d, J=8.9 Hz, 1H, 8-H), 7.6 (dd, J=8.9 Hz/2.7 Hz, 1H, 7-H), 7.68 (d, J=2.7 Hz, 1H, 5-H); 13C NMR (DMSO-d6) δ 36.8 (C-3), 66.9 (C-2), 120.3 (C-8) 122.0 (C-4a/C-6), 125.3 (C-5), 135.6 (C-7), 160.1 (C-8a), 190.6 (C-4).
References
[1] Chinese Journal of Chemistry, 2011, vol. 29, # 4, p. 757 - 764
[2] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 834 - 844
[3] Journal of the Indian Chemical Society, 1939, vol. 16, p. 639,644
[4] Journal of the Indian Chemical Society, 1957, vol. 34, p. 467,468
[5] Journal of the American Chemical Society, 1954, vol. 76, p. 5065,5067
6-CHLOROCHROMAN-4-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
6-CHLOROCHROMAN-4-ONE Suppliers
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View Lastest Price from 6-CHLOROCHROMAN-4-ONE manufacturers
- Product
- 6-Chlorochromanone 37674-72-9
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 6-Chloro-4-chromanone 37674-72-9
- Price
- US $74.00-178.00/g
- Min. Order
- 5g
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2023-12-07
- Product
- 6-Chloro-4-chromanone 37674-72-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-01