ChemicalBook > CAS DataBase List > HA14-1

HA14-1

Product Name
HA14-1
CAS No.
65673-63-4
Chemical Name
HA14-1
Synonyms
CS-392;HA14-1;HA14-1/HA141;HA14-1 USP/EP/BP;HA14-1;HA-14-1; HA 14-1;ethyl 6-broMo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chroMene-3-carboxylate;[Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate];2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester;ETHYL [2-AMINO-6-BROMO-4-(1-CYANO-2-ETHOXY-2-OXOETHYL)]-4H-CHROMENE-3-CARBOXYLATE;Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate
CBNumber
CB2170185
Molecular Formula
C17H17BrN2O5
Formula Weight
409.23
MOL File
65673-63-4.mol
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HA14-1 Property

Melting point:
105 °C
Density 
1.480
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: 26 mg/mL
form 
powder
CAS DataBase Reference
65673-63-4
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14876
Product name
HA 14-1
Purity
≥98%
Packaging
5mg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
14876
Product name
HA 14-1
Purity
≥98%
Packaging
10mg
Price
$48
Updated
2021/12/16
Cayman Chemical
Product number
14876
Product name
HA 14-1
Purity
≥98%
Packaging
25mg
Price
$113
Updated
2021/12/16
Cayman Chemical
Product number
14876
Product name
HA 14-1
Purity
≥98%
Packaging
50mg
Price
$163
Updated
2021/12/16
Tocris
Product number
1541
Product name
HA 14-1
Packaging
5
Price
$72
Updated
2021/12/16
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HA14-1 Chemical Properties,Usage,Production

Uses

HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor.

Definition

ChEBI: 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylic acid ethyl ester is a 1-benzopyran.

Biological Activity

Cell-permeable inhibitor of Bcl-2 protein (IC 50 ~ 9 μ M); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells.

Biochem/physiol Actions

HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

HA14-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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HA14-1 Suppliers

Belgium 1 China 94 Germany 2 India 1 Switzerland 2 United Kingdom 3 United States 23 Global 126
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View Lastest Price from HA14-1 manufacturers

Career Henan Chemical Co
Product
HA14-1 65673-63-4
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

65673-63-4, HA14-1Related Search:

3-(5-BROMO-2-METHOXYPHENYL)PROPANOIC ACID 3-(3-BROMOPHENYL)PROPIONITRILE METHYL 3-(2-HYDROXYPHENYL)PROPIONATE ETHYL 2-CYANOVALERATE Ethyl 2-cyanopropanoate 3-Phenylglutaric acid 3-(3-Bromophenyl)propionic acid 3-(2-METHOXYPHENYL)PROPIONIC ACID 3-(3-Bromophenyl)-2-methylprop-1-ene HA14-1 ETHYL 2-CYANOBUTANOATE 3-(2-HYDROXY-PHENYL)-PROPIONIC ACID ETHYL ESTER ethyl 2-cyano-3-phenyl-propanoate DIETHYL 2-METHYLGLUTARATE 2-Cyano-pentanedioic acid diethyl ester 3-(2-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER 3-(3-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER 1-ALLYL-3-BROMOBENZENE

  • 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(4H)-1-benzopyrane-4-aceticacidethylester
  • ethyl 6-broMo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chroMene-3-carboxylate
  • 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester, Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate
  • [Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate], Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate
  • 2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester
  • 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester
  • Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate
  • CS-392
  • Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate 97%
  • HA 14-1, Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate, 2-[2-Amino-6-bromo-3-(ethoxycarbonyl)-4H-chromen-4-yl]-3-ethoxy-3-oxopropanenitrile
  • (R)-ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
  • 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester HA 14-1
  • HA 14-1 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester
  • [Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate]
  • Ethyl2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate97%
  • HA14-1;HA-14-1; HA 14-1
  • ethyl (4S)-2-amino-6-bromo-4-[(R)-cyano-ethoxycarbonyl-methyl]-4H-chromene-3-carboxylate
  • HA14-1
  • ETHYL [2-AMINO-6-BROMO-4-(1-CYANO-2-ETHOXY-2-OXOETHYL)]-4H-CHROMENE-3-CARBOXYLATE
  • 2-AMINO-6-BROMO-ALPHA-CYANO-3-(ETHOXYCARBONYL)-4H-1-BENZOPYRAN-4-ACETIC ACID ETHYL ESTER
  • 4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-, ethyl ester, (αR,4R)-rel-
  • HA14-1 USP/EP/BP
  • rel-(R)-Ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate(relative)
  • rel-Ethyl (αR,4R)-2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetate
  • HA14-1/HA141
  • 65673-63-4
  • C17H17BrN2O5
  • Apoptosis and Cell Cycle
  • BioChemical
  • Cell Biology
  • Apoptosis Inducers
  • Cell Signaling and Neuroscience
  • Inhibitors
  • Caspases/Apoptosis
  • Inhibitor