HA14-1

ChemicalBook > CAS DataBase List > HA14-1

Product Name: HA14-1
CAS No.: 65673-63-4
Chemical Name: HA14-1
Synonyms: CS-392;HA14-1;HA14-1/HA141;HA14-1 USP/EP/BP;HA14-1;HA-14-1; HA 14-1;HA14-1, Bcl-2 inhibitor. BH-3 mimetic.;ethyl 6-broMo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chroMene-3-carboxylate;[Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate];2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester;ETHYL [2-AMINO-6-BROMO-4-(1-CYANO-2-ETHOXY-2-OXOETHYL)]-4H-CHROMENE-3-CARBOXYLATE
CBNumber: CB2170185
Molecular Formula: C17H17BrN2O5
Formula Weight: 409.23
MOL File: 65673-63-4.mol

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HA14-1 Property

Melting point:: 105 °C
Density: 1.480
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: 26 mg/mL
form: powder
color: White to light yellow
CAS DataBase Reference: 65673-63-4

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14876
Product name: HA 14-1
Purity: ≥98%
Packaging: 5mg
Price: $25
Updated: 2021/12/16

Cayman Chemical

Product number: 14876
Product name: HA 14-1
Purity: ≥98%
Packaging: 10mg
Price: $48
Updated: 2021/12/16

Cayman Chemical

Product number: 14876
Product name: HA 14-1
Purity: ≥98%
Packaging: 25mg
Price: $113
Updated: 2021/12/16

Cayman Chemical

Product number: 14876
Product name: HA 14-1
Purity: ≥98%
Packaging: 50mg
Price: $163
Updated: 2021/12/16

Tocris

Product number: 1541
Product name: HA 14-1
Packaging: 5
Price: $72
Updated: 2021/12/16

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HA14-1 Chemical Properties,Usage,Production

Uses

HA14-1 is a cell-permeable, nonpeptidic Bcl-2 inhibitor.

Definition

ChEBI: 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylic acid ethyl ester is a 1-benzopyran.

Biological Activity

Cell-permeable inhibitor of Bcl-2 protein (IC 50 ~ 9 μ M); acts by binding to the surface pocket. Disrupts Bax/Bcl-2 interaction and induces apoptosis of tumor cells.

Biochem/physiol Actions

HA 14-1 is a nonpeptide apoptosis inducer; Bcl-2 antagonist.

HA14-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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HA14-1 Suppliers

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View Lastest Price from HA14-1 manufacturers

Career Henan Chemical Co

Product: HA14-1 65673-63-4
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

65673-63-4, HA14-1Related Search:

3-(5-BROMO-2-METHOXYPHENYL)PROPANOIC ACID 3-(3-BROMOPHENYL)PROPIONITRILE METHYL 3-(2-HYDROXYPHENYL)PROPIONATE ETHYL 2-CYANOVALERATE Ethyl 2-cyanopropanoate 3-Phenylglutaric acid 3-(3-Bromophenyl)propionic acid 3-(2-METHOXYPHENYL)PROPIONIC ACID 3-(3-Bromophenyl)-2-methylprop-1-ene HA14-1 ETHYL 2-CYANOBUTANOATE 3-(2-HYDROXY-PHENYL)-PROPIONIC ACID ETHYL ESTER ethyl 2-cyano-3-phenyl-propanoate DIETHYL 2-METHYLGLUTARATE 2-Cyano-pentanedioic acid diethyl ester 3-(2-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER 3-(3-BROMO-PHENYL)-PROPIONIC ACID ETHYL ESTER 1-ALLYL-3-BROMOBENZENE

2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(4H)-1-benzopyrane-4-aceticacidethylester

ethyl 6-broMo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chroMene-3-carboxylate

2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester, Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate

[Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate], Ethyl [2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)]-4H-chromene-3-carboxylate

2-Amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-aceticacidethylester

2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester

Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate

CS-392

Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate 97%

HA 14-1, Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate, 2-[2-Amino-6-bromo-3-(ethoxycarbonyl)-4H-chromen-4-yl]-3-ethoxy-3-oxopropanenitrile

(R)-ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester HA 14-1

HA 14-1 2-Amino-6-bromo-alpha-cyano-3-(ethoxycarbonyl)-(alphaR,4R)-rel-4H-1-benzopyran-4-acetic acid ethyl ester

[Ethyl 2-amino-6-bromo-4-(1cyano-2-ethoxy-2-oxoethyl)-4H-chromene3-3carboxylate]

Ethyl2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate97%

HA14-1;HA-14-1; HA 14-1

ethyl (4S)-2-amino-6-bromo-4-[(R)-cyano-ethoxycarbonyl-methyl]-4H-chromene-3-carboxylate

HA14-1

ETHYL [2-AMINO-6-BROMO-4-(1-CYANO-2-ETHOXY-2-OXOETHYL)]-4H-CHROMENE-3-CARBOXYLATE

2-AMINO-6-BROMO-ALPHA-CYANO-3-(ETHOXYCARBONYL)-4H-1-BENZOPYRAN-4-ACETIC ACID ETHYL ESTER

4H-1-Benzopyran-4-acetic acid, 2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-, ethyl ester, (αR,4R)-rel-

HA14-1 USP/EP/BP

rel-(R)-Ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate(relative)

rel-Ethyl (αR,4R)-2-amino-6-bromo-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetate

HA14-1/HA141

HA14-1, Bcl-2 inhibitor. BH-3 mimetic.

65673-63-4

C17H17BrN2O5

Apoptosis and Cell Cycle

BioChemical

Cell Biology

Apoptosis Inducers

Cell Signaling and Neuroscience

Inhibitors

Caspases/Apoptosis

Inhibitor