ChemicalBook > CAS DataBase List > 5-chloro-N-methylpyridin-2-amine

5-chloro-N-methylpyridin-2-amine

Product Name
5-chloro-N-methylpyridin-2-amine
CAS No.
4214-80-6
Chemical Name
5-chloro-N-methylpyridin-2-amine
Synonyms
UKRORGSYN-BB BBR-009506;5-Chloro-2-MethylaMinopyridine;5-Chloro-2-(MethylaMino)pyridine;5-chloro-N-methylpyridin-2-amine;5-Chloro-N-methyl-2-pyridinamine;5-Chloro-N-Methyl-2-pyridineaMine;2-PyridinaMine, 5-chloro-N-Methyl-;5-Chloro-N-methylpyridin-2-ylamine;(5-Chloro-pyridin-2-yl)-methyl-amine
CBNumber
CB21778216
Molecular Formula
C6H7ClN2
Formula Weight
142.59
MOL File
4214-80-6.mol
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5-chloro-N-methylpyridin-2-amine Property

Melting point:
63-65°C
Boiling point:
247℃
Density 
1.250
Flash point:
103℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO, Methanol
form 
Solid
pka
5.00±0.10(Predicted)
color 
Off-White
InChI
InChI=1S/C6H7ClN2/c1-8-6-3-2-5(7)4-9-6/h2-4H,1H3,(H,8,9)
InChIKey
KSISYWKRGRATSK-UHFFFAOYSA-N
SMILES
C1(NC)=NC=C(Cl)C=C1
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C369060
Product name
5-Chloro-2-methylaminopyridine
Packaging
500mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20026
Product name
5-Chloro-2-methylaminopyridine
Packaging
100mg
Price
$112
Updated
2021/12/16
Apolloscientific
Product number
OR927031
Product name
5-Chloro-N-methylpyridin-2-amine
Purity
98%
Packaging
1g
Price
$125
Updated
2021/12/16
AK Scientific
Product number
Y9067
Product name
(5-Chloropyridin-2-yl)methanamine
Packaging
1g
Price
$171
Updated
2021/12/16
SynQuest Laboratories
Product number
3H31-5-AQ
Product name
5-Chloro-N-methylpyridin-2-amine
Purity
98%
Packaging
1g
Price
$200
Updated
2021/12/16
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5-chloro-N-methylpyridin-2-amine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

5-Chloro-2-methylaminopyridine is used in the preparation of aminosulfuranes with N-heterocyclic groups.

Synthesis

1072-98-6

7318-81-2

4214-80-6

GENERAL METHOD: Copper(II) acetate (0.550 g, 3.03 mmol) was added to a solution of 2-amino-5-chloropyridine (1.22 mmol) and pyridine (0.34 mL, 4.24 mmol) in dioxane (15 mL). The mixture was stirred for 15 min, methylboronic acid (0.181 g, 3.03 mmol) was added and the reaction was refluxed until the 2-amino-5-chloropyridine was completely consumed (reaction time monitored by TLC analysis, 1.5-18 h). The reaction mixture was allowed to cool to room temperature, filtered through diatomaceous earth and the solvent was evaporated. The residue was purified by fast chromatography (elution gradient: 0→50% ethyl acetate/hexane) to give 5-chloro-N-methylpyridin-2-amine (162). Preparation of 5-chloro-N-methylpyridin-2-amine (162): compound 162 was prepared from 2-amino-5-chloropyridine (160) according to the above method F. 73 mg of brown powder was obtained in 42% yield. 1H NMR (500 MHz, CDCl3) δ 2.90 (s, 3H), 4.79 (br s, 1H), 6.33 (d, J = 8.9 Hz, 1H), 7.38 (dd, J = 2.6, 8.9 Hz, 1H), 8.02 (d, J = 2.6 Hz, 1H). 13C NMR (126 MHz, CDCl3) δ 29.22, 106.90, 119.44, 137.27, 146.26, 157.88. LC-MS (M + H+) calculated value C6H7ClN2 143, measured value 143.

References

[1] Patent: WO2014/100833, 2014, A1. Location in patent: Paragraph 0081; 0233

5-chloro-N-methylpyridin-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-chloro-N-methylpyridin-2-amine Suppliers

Canada 1 China 38 India 1 Ukraine 1 United Kingdom 1 United States 4 Global 46
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
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NE Scientific
Tel
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Fax
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Country
United States
ProdList
5030
Advantage
55
Combi-Blocks Inc.
Tel
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Fax
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Email
sales@combi-blocks.com
Country
United States
ProdList
6618
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69
International Laboratory Limited
Tel
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Fax
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Email
admin@intlab.org
Country
United States
ProdList
5356
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50
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View Lastest Price from 5-chloro-N-methylpyridin-2-amine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5-Chloro-N-methyl-2-pyridineamine 4214-80-6
Price
US $20.00-100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-08-09
Career Henan Chemical Co
Product
5-chloro-N-methylpyridin-2-amine 4214-80-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-17

4214-80-6, 5-chloro-N-methylpyridin-2-amineRelated Search:

6-(5-Chloro-2-pyridyl)-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione Zopiclone N-(5-CHLORO-2-PYRIDINYL)-4-FLUORO-BENZAMIDE 6-CHLORO-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE N-(5-CHLORO-2-PYRIDINYL)-BENZAMIDE 4-CHLORO-N-(5-CHLORO-2-PYRIDINYL)BUTANAMIDE 2-CHLORO-N-(5-CHLOROPYRIDIN-2-YL)ACETAMIDE 1-[5-CHLORO-3-(TRIFLUOROMETHYL)-2-PYRIDYL]-1-METHYLHYDRAZINE 4-bromo-N-(5-chloropyridin-2-yl)benzamide CHEMBRDG-BB 5222291 7-CHLORO-2H-PYRIDO[3,2-B]-1,4-OXAZIN-3(4H)ONE DIETHYL 2-([(5-CHLORO-2-PYRIDINYL)AMINO]METHYLENE)MALONATE 2-[4-[5-CHLORO-3-(TRIFLUOROMETHYL)-2-PYRIDYL]PIPERAZINO]ETHAN-1-OL 5-chloro-N-[(2-chlorophenyl)methyl]pyridin-2-amine 3-([(5-CHLORO-2-PYRIDINYL)AMINO]CARBONYL)-2-PYRAZINECARBOXYLIC ACID N-(5-chloro-2-pyridinyl)-2-methylbenzamide 4-((5-CHLOROPYRIDIN-2-YL)AMINO)-4-OXOBUTANOIC ACID 2-bromo-N-(5-chloropyridin-2-yl)benzamide

  • 2-PyridinaMine, 5-chloro-N-Methyl-
  • 5-chloro-N-methylpyridin-2-amine
  • UKRORGSYN-BB BBR-009506
  • 5-Chloro-2-(MethylaMino)pyridine
  • 5-Chloro-2-MethylaMinopyridine
  • 5-Chloro-N-Methyl-2-pyridineaMine
  • 5-Chloro-N-methyl-2-pyridinamine
  • (5-Chloro-pyridin-2-yl)-methyl-amine
  • 5-Chloro-N-methylpyridin-2-ylamine
  • 4214-80-6