ChemicalBook > CAS DataBase List > 1-BOC-5-CYANOINDOLE

1-BOC-5-CYANOINDOLE

Product Name
1-BOC-5-CYANOINDOLE
CAS No.
475102-10-4
Chemical Name
1-BOC-5-CYANOINDOLE
Synonyms
N-Boc-5-cyanoindole;1-BOC-5-CYANOINDOLE;1-BOC-5-Cyano-1H-indole;N-(tert-Butoxycarbonyl)-5-cyanoindole;tert-Butyl 5-cyano-1H-indole-1-carboxylate;5-cyano-1-indolecarboxylic acid tert-butyl ester;5-Cyano-indole-1-carboxylic acid tert-butyl ester;1H-Indole-1-carboxylic acid, 5-cyano-, 1,1-dimethylethyl ester;1H-Indole-1-carboxylicacid, 5-cyano-, 1,1-dimethylethyl este...
CBNumber
CB2179638
Molecular Formula
C14H14N2O2
Formula Weight
242.27
MOL File
475102-10-4.mol
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1-BOC-5-CYANOINDOLE Property

Melting point:
128-129 °C(Solv: ethanol (64-17-5); hexane (110-54-3))
Boiling point:
386.4±34.0 °C(Predicted)
Density 
1.12±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B201448
Product name
1-BOC-5-cyanoindole
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
B201448
Product name
1-BOC-5-cyanoindole
Packaging
1g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
V6095
Product name
1-BOC-5-cyanoindole
Packaging
5g
Price
$144
Updated
2021/12/16
AK Scientific
Product number
V6095
Product name
1-BOC-5-cyanoindole
Packaging
25g
Price
$384
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0078805
Product name
1-BOC-5-CYANOINDOLE
Purity
95.00%
Packaging
1G
Price
$657.31
Updated
2021/12/16
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1-BOC-5-CYANOINDOLE Chemical Properties,Usage,Production

Synthesis

15861-24-2

24424-99-5

475102-10-4

In a 100 mL round bottom flask, 5-cyanoindole (2.0 g, 14.07 mmol) was dissolved in 20 mL of anhydrous tetrahydrofuran (THF). To this solution, 4-dimethylaminopyridine (DMAP, 0.86 g, 7.03 mmol) was added and the mixture was stirred for 0.5 h at room temperature. Subsequently, di-tert-butyl dicarbonate (Boc2O, 3.07 g, 14.07 mmol) was added and the reaction continued to be stirred for 2 hours. After completion of the reaction, the reaction was quenched with water and extracted with ether (2×). The organic layers were combined, washed sequentially with 1N hydrochloric acid, water and saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated to give 1-Boc-5-cyanoindole (3.26 g, 96% yield) as a white solid. The product was characterized by 1H NMR (DMSO-d6): δ 8.20-8.14 (m, 2H), 7.83 (d, 1H), 7.70 (d, 1H), 6.80 (d, 1H), 1.63 (s, 9H).

References

[1] Synthesis, 2009, # 21, p. 3617 - 3632
[2] Journal of Organic Chemistry, 2002, vol. 67, # 21, p. 7551 - 7552
[3] Patent: WO2004/43950, 2004, A1. Location in patent: Page 134
[4] Patent: WO2005/51957, 2005, A1. Location in patent: Page/Page column 54-55
[5] Patent: WO2011/60389, 2011, A1. Location in patent: Page/Page column 98-99

1-BOC-5-CYANOINDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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475102-10-4, 1-BOC-5-CYANOINDOLERelated Search:

Sodium cyanoborohydride 4-Amino-1-Boc-piperidine 3-BROMO-5-CYANOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 5-CYANO-3-HYDROXYMETHYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 2-(6-Chloro-pyrimidin-4-yl)-5-cyano-indole-1-carboxylic acid tert-butyl ester 1-Boc-5-Cyanoindole-2-boronic acid 5-CYANO-3-IODOINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-5-CYANOINDOLE 2-(2-Chloro-pyrimidin-4-yl)-5-cyano-indole-1-carboxylic acid tert-butyl ester 5-CYANO-3-FORMYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

  • N-Boc-5-cyanoindole
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  • 1-BOC-5-CYANOINDOLE
  • tert-Butyl 5-cyano-1H-indole-1-carboxylate
  • 5-cyano-1-indolecarboxylic acid tert-butyl ester
  • 1H-Indole-1-carboxylicacid, 5-cyano-, 1,1-dimethylethyl este...
  • 5-Cyano-indole-1-carboxylic acid tert-butyl ester
  • 1-BOC-5-Cyano-1H-indole
  • 1H-Indole-1-carboxylic acid, 5-cyano-, 1,1-dimethylethyl ester
  • 475102-10-4
  • blocks
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  • IndolesOxindoles
  • Indole