ChemicalBook > CAS DataBase List > W-7 HYDROCHLORIDE

W-7 HYDROCHLORIDE

Product Name
W-7 HYDROCHLORIDE
CAS No.
61714-27-0
Chemical Name
W-7 HYDROCHLORIDE
Synonyms
W-7;SKL179;CS-1064;ulfonaMide;W-7 HYDROCHLORIDE;OMEGA-7 HYDROCHLORIDE;W-7 hydrochloride, 10 mM in DMSO;W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL
CBNumber
CB2182197
Molecular Formula
C16H22Cl2N2O2S
Formula Weight
377.33
MOL File
61714-27-0.mol
More
Less

W-7 HYDROCHLORIDE Property

Melting point:
220-222 °C
storage temp. 
-20°C
solubility 
methanol: 25 mg/mL, clear, colorless
form 
Off-white crystalline solid
color 
White to Off-White
BRN 
6030174
InChI
InChI=1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H
InChIKey
OMMOSRLIFSCDBL-UHFFFAOYSA-N
SMILES
C1(C=CC=C2C(Cl)=CC=CC=12)S(=O)(=O)NCCCCCCN.Cl
CAS DataBase Reference
61714-27-0(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
QK0786000
F 
3-10
HS Code 
2935909099
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A3281
Product name
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Packaging
25mg
Price
$161
Updated
2025/07/31
Sigma-Aldrich
Product number
681629
Product name
W-7, Hydrochloride
Packaging
10mg
Price
$148
Updated
2025/07/31
TCI Chemical
Product number
A2409
Product name
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride
Packaging
100MG
Price
$180
Updated
2025/07/31
TCI Chemical
Product number
A2409
Product name
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride
Packaging
1G
Price
$647
Updated
2025/07/31
Cayman Chemical
Product number
14826
Product name
W-7 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$57
Updated
2024/03/01
More
Less

W-7 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. W-7 is a cell-permeable antagonist of calmodulin (Ki = 11 μM). Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins. W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (Ki = 70 and 300 μM, respectively).

Chemical Properties

White Crystalline Solid

Uses

W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities.

Uses

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride has been used to study its effect of on coated pit staining.

General Description

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 51 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM).

Biological Activity

Calmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M).

Biochem/physiol Actions

Cell permeable: yes

storage

Store at RT

References

[1] G. BENAIM A V. Phosphorylation of calmodulin. Functional implications.[J]. European journal of biochemistry, 2002, 61 1: 3619-3631. DOI: 10.1046/j.1432-1033.2002.03038.x
[2] D CHIN  A R M. Calmodulin: a prototypical calcium sensor.[J]. Trends in Cell Biology, 2000, 10 8: 322-328. DOI: 10.1016/s0962-8924(00)01800-6
[3] OSAWA M, SWINDELLS M, TANIKAWA J, et al. SOLUTION NMR STRUCTURE OF CALMODULIN/W-7 COMPLEX: THE BASIS OF DIVERSITY IN MOLECULAR RECOGNITION, 30 STRUCTURES[C]. 1998: 0. DOI: 10.2210/pdb1mux/pdb
[4] H HIDAKA. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1981, 78 7: 4354-4357. DOI: 10.1073/pnas.78.7.4354
[5] BISHOW B ADHIKARI  Kuan W. Interplay of troponin- and Myosin-based pathways of calcium activation in skeletal and cardiac muscle: the use of W7 as an inhibitor of thin filament activation.[J]. Biophysical journal, 2004, 86 1 Pt 1: 359-370. DOI: 10.1016/s0006-3495(04)74112-0
[6] RYAN M. B. HOFFMAN  Brian D S. Structure of the Inhibitor W7 Bound to the Regulatory Domain of Cardiac Troponin C[J]. Biochemistry Biochemistry, 2009, 48 24: 5541-5552. DOI: 10.1021/bi9001826

W-7 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

W-7 HYDROCHLORIDE Suppliers

Americas 1 Canada 1 China 124 Europe 1 Germany 2 India 3 Japan 3 Switzerland 2 United Kingdom 8 United States 21 Global 166
Xingji Pharmaceutical (Shanghai) Co., Ltd
Tel
15705593425
Email
support@utgene.com
Country
China
ProdList
316
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80

61714-27-0, W-7 HYDROCHLORIDERelated Search:

1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE 1-Chloronaphthalene W-7 HYDROCHLORIDE 1,6-HEXANEDIAMINE DIHYDROCHLORIDE N-n-Butyl benzene sulfonamide 1-(2,4-DICHLOROPHENYL)HYDRAZINE HYDROCHLORIDE -EthylbenzenesulfonaMide 1,2,5,6-TETRAHYDRO-1-METHYL-NICOTINIC ACID HYDROCHLORIDE (+/-)-1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE HYDROCHLORIDE [+/-]-1-[2,5-DIMETHOXYPHENYL]-2-GLYCINAMIDOETHANOL HYDROCHLORIDE 1-(2,4-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE 1-(2,3-DIMETHYLPHENYL)PIPERAZINE HYDROCHLORIDE 10,11-dihydro-5-(3-(dimethylamino)propyl)-5h-dibenz[b,f]azepine hydrochloride 1-(2,6-DICHLOROPHENYL)HYDRAZINE HYDROCHLORIDE 1-(2,4-DIFLUOROPHENYL)HYDRAZINE HYDROCHLORIDE 1-(2,5-DIMETHOXYBENZYL)PIPERAZINE HYDROCHLORIDE W-5 HYDROCHLORIDE 1-(2,5-DIFLUOROPHENYL)BIGUANIDE HYDROCHLORIDE

  • OMEGA-7 HYDROCHLORIDE
  • N-(6-AMINOHEXYL)-5-CHLORONAPHTHALENE-1-SULFONAMIDE HYDROCHLORIDE
  • N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL
  • N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
  • N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULPHONAMIDE HYDROCHLORIDE
  • W-7
  • W-7 HYDROCHLORIDE
  • N-(6-Aminohexyl)-5-chloronaphthalene-1-sulphonamide hydrochloride
  • 1-Naphthalenesulfonamide, N-(6-aminohexyl)-5-chloro-, monohydrochloride
  • N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide monohydrochloride
  • N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE
  • N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride,W-7
  • ulfonaMide
  • W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem
  • CS-1064
  • 6-[(5-chloro-1-naphthalenyl)sulfonylamino]hexylammonium
  • N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride &gt
  • SKL179
  • 6-{[(5-chloronaphthalen-1-yl)sulfonyl]amino}hexan-1-aminium
  • Inhibitor,Phosphodiesterase (PDE),anti-proliferation,Calcium-modulated protein,light,chain,Apoptosis,W7 hydrochloride,W 7 hydrochloride,W 7,Ca2+,Calmodulin,W-7,inhibit,CaM,phosphodiesterase,Myosin,phosphate,antitumor
  • W-7 hydrochloride, 10 mM in DMSO
  • 61714-27-0
  • C16H21ClN2O2SClH
  • Antibiotics
  • Antibiotics A to Z
  • Antibiotics A-F
  • BioChemical
  • All Inhibitors
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
  • Calcium signaling