ChemicalBook > CAS DataBase List > W-7 HYDROCHLORIDE

W-7 HYDROCHLORIDE

Product Name: W-7 HYDROCHLORIDE
CAS No.: 61714-27-0
Chemical Name: W-7 HYDROCHLORIDE
Synonyms: W-7;SKL179;CS-1064;ulfonaMide;W-7 HYDROCHLORIDE;OMEGA-7 HYDROCHLORIDE;W-7 hydrochloride, 10 mM in DMSO;W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL
CBNumber: CB2182197
Molecular Formula: C16H22Cl2N2O2S
Formula Weight: 377.33
MOL File: 61714-27-0.mol

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W-7 HYDROCHLORIDE Property

Melting point:: 220-222 °C
storage temp.: -20°C
solubility: methanol: 25 mg/mL, clear, colorless
form: Off-white crystalline solid
color: White to Off-White
BRN: 6030174
InChI: InChI=1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H
InChIKey: OMMOSRLIFSCDBL-UHFFFAOYSA-N
SMILES: C1(C=CC=C2C(Cl)=CC=CC=12)S(=O)(=O)NCCCCCCN.Cl
CAS DataBase Reference: 61714-27-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 22-24/25
WGK Germany: 3
RTECS: QK0786000
F: 3-10
HS Code: 2935909099

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A3281
Product name: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
Packaging: 25mg
Price: $161
Updated: 2025/07/31

Sigma-Aldrich

Product number: 681629
Product name: W-7, Hydrochloride
Packaging: 10mg
Price: $148
Updated: 2025/07/31

TCI Chemical

Product number: A2409
Product name: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride
Packaging: 100MG
Price: $180
Updated: 2025/07/31

TCI Chemical

Product number: A2409
Product name: N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride
Packaging: 1G
Price: $647
Updated: 2025/07/31

Cayman Chemical

Product number: 14826
Product name: W-7 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $57
Updated: 2024/03/01

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W-7 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. W-7 is a cell-permeable antagonist of calmodulin (K_i = 11 μM). Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins. W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (K_i = 70 and 300 μM, respectively).

Chemical Properties

White Crystalline Solid

Uses

W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities.

Uses

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride has been used to study its effect of on coated pit staining.

General Description

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 51 μM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 μM).

Biological Activity

Calmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M).

Biochem/physiol Actions

Cell permeable: yes

storage

Store at RT

References

[1] G. BENAIM A V. Phosphorylation of calmodulin. Functional implications.[J]. European journal of biochemistry, 2002, 61 1: 3619-3631. DOI: 10.1046/j.1432-1033.2002.03038.x
[2] D CHIN A R M. Calmodulin: a prototypical calcium sensor.[J]. Trends in Cell Biology, 2000, 10 8: 322-328. DOI: 10.1016/s0962-8924(00)01800-6
[3] OSAWA M, SWINDELLS M, TANIKAWA J, et al. SOLUTION NMR STRUCTURE OF CALMODULIN/W-7 COMPLEX: THE BASIS OF DIVERSITY IN MOLECULAR RECOGNITION, 30 STRUCTURES[C]. 1998: 0. DOI: 10.2210/pdb1mux/pdb
[4] H HIDAKA. N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1981, 78 7: 4354-4357. DOI: 10.1073/pnas.78.7.4354
[5] BISHOW B ADHIKARI Kuan W. Interplay of troponin- and Myosin-based pathways of calcium activation in skeletal and cardiac muscle: the use of W7 as an inhibitor of thin filament activation.[J]. Biophysical journal, 2004, 86 1 Pt 1: 359-370. DOI: 10.1016/s0006-3495(04)74112-0
[6] RYAN M. B. HOFFMAN Brian D S. Structure of the Inhibitor W7 Bound to the Regulatory Domain of Cardiac Troponin C[J]. Biochemistry Biochemistry, 2009, 48 24: 5541-5552. DOI: 10.1021/bi9001826

W-7 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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W-7 HYDROCHLORIDE Suppliers

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61714-27-0, W-7 HYDROCHLORIDERelated Search:

1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE 1-Chloronaphthalene W-7 HYDROCHLORIDE 1,6-HEXANEDIAMINE DIHYDROCHLORIDE N-n-Butyl benzene sulfonamide 1-(2,4-DICHLOROPHENYL)HYDRAZINE HYDROCHLORIDE -EthylbenzenesulfonaMide 1,2,5,6-TETRAHYDRO-1-METHYL-NICOTINIC ACID HYDROCHLORIDE (+/-)-1-(2,5-DIMETHOXY-4-IODOPHENYL)-2-AMINOPROPANE HYDROCHLORIDE [+/-]-1-[2,5-DIMETHOXYPHENYL]-2-GLYCINAMIDOETHANOL HYDROCHLORIDE 1-(2,4-DIMETHYLPHENYL)HYDRAZINE HYDROCHLORIDE 1-(2,3-DIMETHYLPHENYL)PIPERAZINE HYDROCHLORIDE 10,11-dihydro-5-(3-(dimethylamino)propyl)-5h-dibenz[b,f]azepine hydrochloride 1-(2,6-DICHLOROPHENYL)HYDRAZINE HYDROCHLORIDE 1-(2,4-DIFLUOROPHENYL)HYDRAZINE HYDROCHLORIDE 1-(2,5-DIMETHOXYBENZYL)PIPERAZINE HYDROCHLORIDE W-5 HYDROCHLORIDE 1-(2,5-DIFLUOROPHENYL)BIGUANIDE HYDROCHLORIDE

OMEGA-7 HYDROCHLORIDE

N-(6-AMINOHEXYL)-5-CHLORONAPHTHALENE-1-SULFONAMIDE HYDROCHLORIDE

N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL

N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE

N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULPHONAMIDE HYDROCHLORIDE

W-7

W-7 HYDROCHLORIDE

N-(6-Aminohexyl)-5-chloronaphthalene-1-sulphonamide hydrochloride

1-Naphthalenesulfonamide, N-(6-aminohexyl)-5-chloro-, monohydrochloride

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide monohydrochloride

N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride,W-7

ulfonaMide

W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem

CS-1064

6-[(5-chloro-1-naphthalenyl)sulfonylamino]hexylammonium

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride &gt

SKL179

6-{[(5-chloronaphthalen-1-yl)sulfonyl]amino}hexan-1-aminium

Inhibitor,Phosphodiesterase (PDE),anti-proliferation,Calcium-modulated protein,light,chain,Apoptosis,W7 hydrochloride,W 7 hydrochloride,W 7,Ca2+,Calmodulin,W-7,inhibit,CaM,phosphodiesterase,Myosin,phosphate,antitumor

W-7 hydrochloride, 10 mM in DMSO

61714-27-0

C16H21ClN2O2SClH

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Protein Kinase Inhibitors and Activators

Calcium signaling