ChemicalBook > CAS DataBase List > 5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate

5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate

Product Name
5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate
CAS No.
1053656-51-1
Chemical Name
5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate
Synonyms
O5-tert-butyl O2-ethyl 6,7-dihydro-4H-thiazolo[5,4-c]pyridine-2,5-dicarboxylate;Ethyl 5-Boc-4,5,6,7-tetrahydrothiazolo;6,7-dihydro-, 5-(1,1-dimethylethyl) 2-ethyl ester;5-tert-Butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H);Ethyl 5-Boc-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate;Ethyl 5-Boc-4,5,6,7-tetrahydro-1,3-thiazolo[5,4-c]pyridine-2-carboxylate;5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate;5-(tert-Butyl) 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridin-2,5(4H)-dicarboxylate;5-tert-butyl 2-ethyl 4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2,5-dicarboxylate;6,7-dihydrothiazolo(5,4-c)pyridine-2,5(4h)-dicarboxylic acid 5-(tert-butyl) 2-ethyl
CBNumber
CB21856154
Molecular Formula
C14H20N2O4S
Formula Weight
312.38
MOL File
1053656-51-1.mol
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5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate Property

Boiling point:
429.0±55.0 °C(Predicted)
Density 
1.241
storage temp. 
2-8°C
pka
0.72±0.20(Predicted)
Appearance
White to yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific
Product number
Y6630
Product name
Ethyl5-Boc-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate
Packaging
100mg
Price
$118
Updated
2021/12/16
AK Scientific
Product number
Y6630
Product name
Ethyl5-Boc-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate
Packaging
1g
Price
$329
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0077264
Product name
5-TERT-BUTYL 2-ETHYL 6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-2,5(4H)-DICARBOXYLATE
Purity
95.00%
Packaging
1G
Price
$1357.13
Updated
2021/12/16
Matrix Scientific
Product number
132820
Product name
5-tert-Butyl 2-ethyl 6,7-dihydrothiazolo-[5,4-c]pyridine-2,5(4H)-dicarboxylate
Purity
97%
Packaging
5g
Price
$1918
Updated
2021/12/16
Matrix Scientific
Product number
132820
Product name
5-tert-Butyl 2-ethyl 6,7-dihydrothiazolo-[5,4-c]pyridine-2,5(4H)-dicarboxylate
Purity
97%
Packaging
10g
Price
$2700
Updated
2021/12/16
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5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate Chemical Properties,Usage,Production

Synthesis

16982-21-1

188869-05-8

1053656-51-1

General procedure for the synthesis of ethyl 5-Boc-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate from ethyl thiooxalate and N-Boc-3-bromo-4-oxo piperidine: N-Boc-3-bromo-4-oxo piperidine (4.0 g, 14.4 mmol) was dissolved in isopropanol (IPA, 25 mL). Ethyl thiooxalate (1.60 g, 12.0 mmol) and sodium bicarbonate (NaHCO3, 2.01 g, 24.0 mmol) were added. The reaction mixture was heated to reflux for 12 hours and subsequently concentrated under reduced pressure. The residue was dissolved in water (63 mL) and extracted with dichloromethane. The organic layer was washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford the target compound, ethyl 5-Boc-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate (2.2 g, 60% yield), which was pure enough to be used in the subsequent reaction directly. The product characterization data were as follows: melting point: 138-140 °C; 1H NMR (300 MHz, CDCl3): δ 4.71 (s, 2H), 4.48 (q, J = 12Hz, 2H), 3.72 (m, 2H), 2.96 (t, J = 5.4Hz, 2H), 2.41 (t, J = 6.3Hz, 2H), 1.51 (s, 9H) , 1.44 (t, J = 1.2 Hz, 3H); MS (ESI) m/z: 335.1 [M + Na]+.

References

[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 23-24, p. 5987 - 5999
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 2, p. 443 - 454

5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate Suppliers

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View Lastest Price from 5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate 1053656-51-1
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-12
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate 1053656-51-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate 1053656-51-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-08

1053656-51-1, 5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylateRelated Search:

5-(Tert-Butoxycarbonyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid 6,8-dibromo-[1,2,4]triazolo[1,5-a]pyrazine Chitosan

  • 5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate
  • 5-tert-Butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)
  • 6,7-dihydro-, 5-(1,1-dimethylethyl) 2-ethyl ester
  • 6,7-Dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylic acid 5-(tert-butyl) 2-ethyl ester
  • Ethyl 5-Boc-4,5,6,7-tetrahydro-1,3-thiazolo[5,4-c]pyridine-2-carboxylate
  • 5-tert-butyl 2-ethyl 4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2,5-dicarboxylate
  • Ethyl 5-Boc-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate
  • 6,7-dihydrothiazolo(5,4-c)pyridine-2,5(4h)-dicarboxylic acid 5-(tert-butyl) 2-ethyl
  • O5-tert-butyl O2-ethyl 6,7-dihydro-4H-thiazolo[5,4-c]pyridine-2,5-dicarboxylate
  • Thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylic acid, 6,7-dihydro-, 5-(1,1-dimethylethyl) 2-ethyl ester
  • 5-O-tert-butyl2-O-ethyl6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2,5-dicarboxylate
  • 5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate ISO 9001：2015 REACH
  • Ethyl 5-Boc-4,5,6,7-tetrahydrothiazolo
  • 5-(1,1-Dimethylethyl) 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate
  • 5-(tert-Butyl) 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridin-2,5(4H)-dicarboxylate
  • 1053656-51-1
  • 053656-51-1
  • CHIRAL CHEMICALS