5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate

Product Name: 5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate
CAS No.: 1053656-51-1
Chemical Name: 5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate
Synonyms: O5-tert-butyl O2-ethyl 6,7-dihydro-4H-thiazolo[5,4-c]pyridine-2,5-dicarboxylate;Ethyl 5-Boc-4,5,6,7-tetrahydrothiazolo;6,7-dihydro-, 5-(1,1-dimethylethyl) 2-ethyl ester;5-tert-Butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H);Ethyl 5-Boc-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate;Ethyl 5-Boc-4,5,6,7-tetrahydro-1,3-thiazolo[5,4-c]pyridine-2-carboxylate;5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate;5-(tert-Butyl) 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridin-2,5(4H)-dicarboxylate;5-tert-butyl 2-ethyl 4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2,5-dicarboxylate;6,7-dihydrothiazolo(5,4-c)pyridine-2,5(4h)-dicarboxylic acid 5-(tert-butyl) 2-ethyl
CBNumber: CB21856154
Molecular Formula: C14H20N2O4S
Formula Weight: 312.38
MOL File: 1053656-51-1.mol

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5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate Property

Boiling point:: 429.0±55.0 °C(Predicted)
Density: 1.241
storage temp.: 2-8°C
pka: 0.72±0.20(Predicted)
Appearance: White to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: Y6630
Product name: Ethyl5-Boc-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate
Packaging: 100mg
Price: $118
Updated: 2021/12/16

AK Scientific

Product number: Y6630
Product name: Ethyl5-Boc-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate
Packaging: 1g
Price: $329
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0077264
Product name: 5-TERT-BUTYL 2-ETHYL 6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-2,5(4H)-DICARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $1357.13
Updated: 2021/12/16

Matrix Scientific

Product number: 132820
Product name: 5-tert-Butyl 2-ethyl 6,7-dihydrothiazolo-[5,4-c]pyridine-2,5(4H)-dicarboxylate
Purity: 97%
Packaging: 5g
Price: $1918
Updated: 2021/12/16

Matrix Scientific

Product number: 132820
Product name: 5-tert-Butyl 2-ethyl 6,7-dihydrothiazolo-[5,4-c]pyridine-2,5(4H)-dicarboxylate
Purity: 97%
Packaging: 10g
Price: $2700
Updated: 2021/12/16

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5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate Chemical Properties,Usage,Production

Synthesis

16982-21-1

188869-05-8

1053656-51-1

General procedure for the synthesis of ethyl 5-Boc-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate from ethyl thiooxalate and N-Boc-3-bromo-4-oxo piperidine: N-Boc-3-bromo-4-oxo piperidine (4.0 g, 14.4 mmol) was dissolved in isopropanol (IPA, 25 mL). Ethyl thiooxalate (1.60 g, 12.0 mmol) and sodium bicarbonate (NaHCO3, 2.01 g, 24.0 mmol) were added. The reaction mixture was heated to reflux for 12 hours and subsequently concentrated under reduced pressure. The residue was dissolved in water (63 mL) and extracted with dichloromethane. The organic layer was washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford the target compound, ethyl 5-Boc-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate (2.2 g, 60% yield), which was pure enough to be used in the subsequent reaction directly. The product characterization data were as follows: melting point: 138-140 °C; 1H NMR (300 MHz, CDCl3): δ 4.71 (s, 2H), 4.48 (q, J = 12Hz, 2H), 3.72 (m, 2H), 2.96 (t, J = 5.4Hz, 2H), 2.41 (t, J = 6.3Hz, 2H), 1.51 (s, 9H) , 1.44 (t, J = 1.2 Hz, 3H); MS (ESI) m/z: 335.1 [M + Na]+.

References

[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 23-24, p. 5987 - 5999
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 2, p. 443 - 454

5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate Preparation Products And Raw materials

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Preparation Products

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5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate Suppliers

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View Lastest Price from 5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate 1053656-51-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate 1053656-51-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate 1053656-51-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-08

1053656-51-1, 5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylateRelated Search:

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5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate

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6,7-dihydro-, 5-(1,1-dimethylethyl) 2-ethyl ester

6,7-Dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylic acid 5-(tert-butyl) 2-ethyl ester

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Thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylic acid, 6,7-dihydro-, 5-(1,1-dimethylethyl) 2-ethyl ester

5-O-tert-butyl2-O-ethyl6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2,5-dicarboxylate

5-tert-butyl 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate ISO 9001：2015 REACH

Ethyl 5-Boc-4,5,6,7-tetrahydrothiazolo

5-(1,1-Dimethylethyl) 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridine-2,5(4H)-dicarboxylate

5-(tert-Butyl) 2-ethyl 6,7-dihydrothiazolo[5,4-c]pyridin-2,5(4H)-dicarboxylate

1053656-51-1

053656-51-1

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