5-Thiazolecarboxaldehyde, 2-cyclopropyl-
- Product Name
- 5-Thiazolecarboxaldehyde, 2-cyclopropyl-
- CAS No.
- 877385-86-9
- Chemical Name
- 5-Thiazolecarboxaldehyde, 2-cyclopropyl-
- Synonyms
- 2-Cyclopropyl-5-formyl-1,3-thiazole;2-cyclopropylthiazole-5-carbaldehyde;2-cyclopropyl-5-Thiazolecarboxaldehyde;5-Thiazolecarboxaldehyde, 2-cyclopropyl-;2-Cyclopropyl-1,3-thiazole-5-carboxaldehyde
- CBNumber
- CB21863530
- Molecular Formula
- C7H7NOS
- Formula Weight
- 153.2
- MOL File
- 877385-86-9.mol
5-Thiazolecarboxaldehyde, 2-cyclopropyl- Property
- Boiling point:
- 278.5±13.0 °C(Predicted)
- Density
- 1.370±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.66±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C7H7NOS/c9-4-6-3-8-7(10-6)5-1-2-5/h3-5H,1-2H2
- InChIKey
- ORNIFVGIJQCIMW-UHFFFAOYSA-N
- SMILES
- S1C(C=O)=CN=C1C1CC1
Safety
- HS Code
- 2934100090
N-Bromosuccinimide Price
- Product number
- C993273
- Product name
- 2-Cyclopropylthiazole-5-carbaldehyde
- Packaging
- 5mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC141855
- Product name
- 2-Cyclopropylthiazole-5-carbaldehyde
- Packaging
- 50mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- FC141855
- Product name
- 2-Cyclopropylthiazole-5-carbaldehyde
- Packaging
- 100mg
- Price
- $146
- Updated
- 2021/12/16
- Product number
- FC141855
- Product name
- 2-Cyclopropylthiazole-5-carbaldehyde
- Packaging
- 250mg
- Price
- $292.5
- Updated
- 2021/12/16
- Product number
- Y4445
- Product name
- 2-Cyclopropylthiazole-5-carbaldehyde
- Packaging
- 250mg
- Price
- $388
- Updated
- 2021/12/16
5-Thiazolecarboxaldehyde, 2-cyclopropyl- Chemical Properties,Usage,Production
Synthesis
1159821-56-3
68-12-2
877385-86-9
Compound 10b (1.8 g, 14.4 mmol) was dissolved in tetrahydrofuran (30 mL) under nitrogen protection and cooled to -78 °C. 2.5 M n-butyllithium (n-BuLi) solution (6.3 mL, 15.8 mmol) was slowly added dropwise and the reaction mixture was stirred at this temperature for 1 hour. Subsequently, N,N-dimethylformamide (DMF) (1.6 g, 21.6 mmol) was added and the mixture was gradually warmed to room temperature and stirring was continued for 3 hours. After completion of the reaction, the reaction was quenched with saturated ammonium chloride (NH4Cl) solution and extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the crude product was purified by silica gel (SiO2) column chromatography with the eluent being a solvent mixture of petroleum ether and ethyl acetate (the ratio was varied from 50:1 to 20:1 gradient) to give the target compound 10c (1.5 g, 49% yield).
References
[1] Patent: WO2014/110705, 2014, A1. Location in patent: Page/Page column 70
[2] Patent: WO2014/110687, 2014, A1. Location in patent: Page/Page column 51
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 1, p. 290 - 306
5-Thiazolecarboxaldehyde, 2-cyclopropyl- Preparation Products And Raw materials
Raw materials
Preparation Products
5-Thiazolecarboxaldehyde, 2-cyclopropyl- Suppliers
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- Fax
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- info@chemstep.com
- Country
- Europe
- ProdList
- 6143
- Advantage
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View Lastest Price from 5-Thiazolecarboxaldehyde, 2-cyclopropyl- manufacturers
- Product
- 2-Cyclopropylthiazole-5-carbaldehyde 877385-86-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- 5-Thiazolecarboxaldehyde, 2-cyclopropyl- 877385-86-9
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18