ChemicalBook > CAS DataBase List > LATRUNCULIN B

LATRUNCULIN B

Product Name
LATRUNCULIN B
CAS No.
76343-94-7
Chemical Name
LATRUNCULIN B
Synonyms
LAT-B;NSC 339663;LATRUNCULIN B;LATRUNCULIN B, LUTRUNCULIA MAGNIFICA;LatrunculinBfromLutrunculiamagnifica;LATRUNCULIN B, LATRUNCULIA MAGNIFICA;Latrunculin B from Latruncula magnifica;Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem;(4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone;2-Thiazolidinone, 4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-, (4R)-
CBNumber
CB2186645
Molecular Formula
C20H29NO5S
Formula Weight
395.51
MOL File
76343-94-7.mol
More
Less

LATRUNCULIN B Property

alpha 
D24 +112° (c = 0.48 in chloroform)
storage temp. 
-20°C
solubility 
DMSO: soluble
form 
solid
color 
light yellow
optical activity
+120.123 (CHCl3)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
428020
Product name
Latrunculin B,
Packaging
1mg
Price
$251
Updated
2024/03/01
Sigma-Aldrich
Product number
428020
Product name
Latrunculin B,
Packaging
5mg
Price
$733
Updated
2024/03/01
Cayman Chemical
Product number
10010631
Product name
Latrunculin B
Purity
≥97%
Packaging
1 mg
Price
$219
Updated
2024/03/01
Cayman Chemical
Product number
10010631
Product name
Latrunculin B
Purity
≥97%
Packaging
50μg
Price
$27
Updated
2022/04/27
Cayman Chemical
Product number
10010631
Product name
Latrunculin B
Purity
≥97%
Packaging
100μg
Price
$51
Updated
2022/04/27
More
Less

LATRUNCULIN B Chemical Properties,Usage,Production

Description

Latrunculin B (76343-94-7) inhibits actin polymerization and disrupts microfilament organization.1 Significantly more potent than cytochalasins in the disruption of microfilament mediated processes2, causes shortening and thickening of stress fibers. Active in cell culture.3,4?Effective doses for latrunculin B vary depending upon cell type but are frequently in the low micromolar range. Note: Latrunculin B is slowly inactivated by fetal bovine serum.

Uses

In elucidation of molecular mechanisms of motile processes.

Uses

Latrunculin B is an actin polymerization inhibitor.

Uses

Latrunculin B from Latruncula magnifica has been used for actin depolymerisation in various experiments. It has also been used as a component in bone marrow-derived dendritic cell (BMDC) complete medium, to study the formation of tubules from phagosomes in dendritic cells.

Definition

ChEBI: A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica.

General Description

Latrunculin B is a macrocyclic toxin, which is produced by Latruncula magnifica.

Biochem/physiol Actions

Primary TargetActin polymerization

storage

Store at -20°C

References

1) Coue?et al. (1987),?Inhibition of actin polymerization by latrunculin; FEBS Lett.,?213?316 2) Spector?et al. (1989),?Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth; Cell Motil. Cytoskeleton,?13?127 3) Wakatsuki?et al. (2001),?Effects of cytochalasin D and latrunculin B on mechanical properties of cells; J. Cell. Sci.,?114?1025 4) Cha?et al. (2004),?The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2 but is dependent on an intact actin cytoskeleton as determined by FRAP; Prog. Clin. Biol. Res.,?230 4 5) Herrera (2021), Cell cultures, transfection and treatments. protocols.io???https://dx.doi.org/10.17504/protocols.io.77ehrje [Focus Citation]

LATRUNCULIN B Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

LATRUNCULIN B Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18043
Advantage
56
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-010-010-62971590 18548936886
Fax
010-62340519
Email
jack@oka-vip.com
Country
China
ProdList
6897
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
56902
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
Advantage
58

76343-94-7, LATRUNCULIN BRelated Search:


  • LATRUNCULIN B
  • LATRUNCULIN B, LATRUNCULIA MAGNIFICA
  • LAT-B
  • LatrunculinBfromLutrunculiamagnifica
  • LATRUNCULIN B, LUTRUNCULIA MAGNIFICA
  • NSC 339663
  • (4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone
  • Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem
  • Latrunculin B from Latruncula magnifica
  • (4R)-4-[(1R,4S,5Z,9Z,13R,15R)-15-hydroxy-4,9-dimethyl-11-oxo-12,16-dioxabicyclo[11.3.1]heptadeca-5,9-dien-15-yl]-1,3-thiazolidin-2-one
  • 2-Thiazolidinone, 4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-, (4R)-
  • 76343-94-7
  • C20H29NSO5
  • C20H29NO5S
  • Cytoskeleton and Extracellular Matrix
  • BioChemical
  • Actin Inhibitors and Probes
  • Cell Signaling and Neuroscience
  • Cell Biology