Amino Tadalafil

Product Name: Amino Tadalafil
CAS No.: 385769-84-6
Chemical Name: Amino Tadalafil
Synonyms: Amino Tadanafil;Amino Tadalafil;Amino tildenafil;Tildenafil Impurity 18;Amino Tadalafil USP/EP/BP;Aminotadalafil in Methanol;Tadalafil N-Desmethyl N-Amino;Tadalafil N-Desmethyl N-Amino Impurity;Amino Tadalafil solution in Methanol, 100μg/mL;(6R,12aR)-2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-he...
CBNumber: CB21872910
Molecular Formula: C21H18N4O4
Formula Weight: 390.39
MOL File: 385769-84-6.mol

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Amino Tadalafil Property

Melting point:: 280-282°C
Boiling point:: 678.9±65.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 16.70±0.40(Predicted)
color: White to Off-White
InChI: InChI=1S/C21H18N4O4/c22-24-9-18(26)25-15(21(24)27)8-13-12-3-1-2-4-14(12)23-19(13)20(25)11-5-6-16-17(7-11)29-10-28-16/h1-7,15,20,23H,8-10,22H2/t15-,20-/m1/s1
InChIKey: VUKJGAVIWMPOOJ-FOIQADDNSA-N
SMILES: N1C2=C(C=CC=C2)C2C[C@]3([H])C(=O)N(N)CC(=O)N3[C@H](C3=CC=C4OCOC4=C3)C1=2
CAS DataBase Reference: 385769-84-6

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Safety

Safety Statements: 24/25
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20876
Product name: Amino Tadalafil
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 20876
Product name: Amino Tadalafil
Purity: ≥98%
Packaging: 10mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 20876
Product name: Amino Tadalafil
Purity: ≥98%
Packaging: 50mg
Price: $335
Updated: 2024/03/01

Cayman Chemical

Product number: 20876
Product name: Amino Tadalafil
Purity: ≥98%
Packaging: 100mg
Price: $547
Updated: 2024/03/01

Usbiological

Product number: 002553
Product name: Amino Tadalafil
Packaging: 5mg
Price: $418
Updated: 2021/12/16

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Amino Tadalafil Chemical Properties,Usage,Production

Description

Amino tadalafil is an analog of tadalafil , a potent inhibitor of phosphodiesterase 5 with applications in several conditions, including erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction. Amino tadalafil has been detected as an illegal adulterant in a dietary supplement marketed for “tonic effect.”

Chemical Properties

White Solid

Uses

Amino Tadalafil is a drug analog of Tadalafil that used to treatment of male erectile dysfunction drugs.

Mechanism of action

Amino tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5).PDE5, an enzyme found primarily in the smooth muscle of the corpus cavernosum, selectively cleaves and degrades cGMP to 5′-GMP. PDE5 inhibitors are similar in structure to cGMP and they competitively bind to PDE5 and inhibit cGMP hydrolysis, thus enhancing the effects of NO, resulting in prolonging an erection.

in vitro

amino-tadalafil is a structural analogue of tadalafil, the active pharmaceutical ingredient in cialis, a prescription drug approved in the us for treatment of erectile dysfunction (ed). similarly, there have also been reports of herbal or dietary supplements being adulterated with designer ed analogues such as amino-tadalafil [1].

in vivo

in rats treated with both melatonin and tadalafil, the recoveries were more pronounced than in rats given either melatonin or tadalafil alone. the icp/mean arterial pressure value in vehicle-treated rats was significantly higher than in the control group, while in the tadalafil- and tadalafil + melatonin-treated groups have returned this value had returned to control levels. in addition, as an individual treatment, and especially when combined with tadalafil, melatonin prevented spinal cord injury (sci)-induced oxidative damage to cavernosal tissues and restored ed, most likely due to its anti-oxidant effects [2].

References

[1] hadwiger me, trehy ml, ye w, moore t, allgire j, westenberger b. identification of amino-tadalafil and rimonabant in electronic cigarette products using high pressure liquid chromatography with diode array and tandem mass spectrometric detection. j chromatogr a. 2010 nov 26;1217(48):7547-55.
[2] tavuk u hh, sener te, tinay i, akbal c, er ahin m, cevik o, cadirci s, reiter rj, sener g. melatonin and tadalafil treatment improves erectile dysfunction after spinal cord injury in rats. clin exp pharmacol physiol. 2014 apr;41(4):309-16.

Amino Tadalafil Preparation Products And Raw materials

Raw materials

Preparation Products

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Amino Tadalafil Suppliers

Canada 2 China 155 India 3 United Kingdom 1 United States 8 Global 169

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View Lastest Price from Amino Tadalafil manufacturers

CONTIDE BIOTECH CO.,LTD

Product: Amino Tadalafil 385769-84-6
Price: US $0.00/G
Min. Order: 1G
Purity: 99
Supply Ability: 20
Release date: 2024-04-12

Hebei Miaoyin Technology Co.,Ltd

Product: Amino Tadalafil 385769-84-6
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000
Release date: 2023-04-18

Wuhan Senwayer Century Chemical Co.,Ltd

Product: Amino Tadalafil 385769-84-6
Price: US $175.00-1100.00/gram
Min. Order: 100gram
Purity: 99% min
Supply Ability: 20 tons
Release date: 2022-10-18

385769-84-6, Amino TadalafilRelated Search:

(1S,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester D(+)-Tryptophan Tadalafil iMpurity B Tadalafil KetolactaM (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester (1R,3R)-2-acetyl-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro- 1H-pyrido[3,4-b]indole-3-carboxylate 1,1'-Ethylidenebis(tryptophan) (1S,3R)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloro-acetyl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylic Acid Methyl Ester N-Octyl Nortadalafil Tadalafil EP Impurity 2-Hydroxypropyl Nortadalafil (1S,3S)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester Vardenafil hydrochloride Carteolol hydrochloride Tadalafil TRIMETHYLSULFOXONIUM BROMIDE vardenafil tadalafi

Amino Tadalafil

(6R,12aR)-2-Amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Amino Tadalafil (6R,12Ar)-2-Amino-6-(1,3-Benzodioxol-5-Yl)-2,3,6,7,12,12A-Hexahydropyrazino[1',2':1,6]Pyrido[3,4-B]Indole-1,4-Dione

Amino Tadanafil

(6R,12aR)-2-Amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-1,4-dione

(6R,12aR)-2-amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione

Best Male Enhancement Drugs 99% Amino Tadalafil powder China manufacturer

Tadalafil N-Desmethyl N-Amino Impurity

Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)-

Amino Tadalafil solution in Methanol, 100μg/mL

Amino Tadalafil USP/EP/BP

(6R,12aR)-2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-he...

Tadalafil N-Desmethyl N-Amino

Amino tildenafil

(6R,12aR)-2-Amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione,2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-, (6R,12aR)-

Aminotadalafil in Methanol

Tildenafil Impurity 18

385769-84-6

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