1H-Indazole-5-carbonitrile, 3-methyl-
- Product Name
- 1H-Indazole-5-carbonitrile, 3-methyl-
- CAS No.
- 267875-55-8
- Chemical Name
- 1H-Indazole-5-carbonitrile, 3-methyl-
- Synonyms
- 3-Methyl-1H-indazole-5-carbonitrile;3-methyl-2H-indazole-5-carbonitrile;1H-Indazole-5-carbonitrile, 3-methyl-
- CBNumber
- CB21874813
- Molecular Formula
- C9H7N3
- Formula Weight
- 157.17
- MOL File
- 267875-55-8.mol
1H-Indazole-5-carbonitrile, 3-methyl- Property
- Boiling point:
- 372.9±22.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.58±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A107718
- Product name
- 3-Methyl-1H-indazole-5-carbonitrile
- Purity
- 98%
- Packaging
- 100mg
- Price
- $166
- Updated
- 2021/12/16
- Product number
- A107718
- Product name
- 3-Methyl-1H-indazole-5-carbonitrile
- Purity
- 98%
- Packaging
- 250mg
- Price
- $218
- Updated
- 2021/12/16
- Product number
- CD11156014
- Product name
- 3-Methyl-1H-indazole-5-carbonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $372
- Updated
- 2021/12/16
- Product number
- A107718
- Product name
- 3-Methyl-1H-indazole-5-carbonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $522
- Updated
- 2021/12/16
- Product number
- CM150147
- Product name
- 3-methyl-1H-indazole-5-carbonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $604
- Updated
- 2021/12/16
1H-Indazole-5-carbonitrile, 3-methyl- Chemical Properties,Usage,Production
Synthesis
170230-87-2
267875-55-8
F. Synthesis of 3-methyl-1H-indazole-5-carbonitrile. An aqueous solution (2 mL) of sodium nitrite (3.6 g, 53 mmol) was slowly added dropwise to a solution of glacial acetic acid (150 mL) of 4-amino-3-ethylbenzonitrile (7.0 g, 48 mmol). The reaction mixture was stirred at room temperature for 16 hours and then concentrated under reduced pressure to one-third of the original volume, followed by the addition of water (200 mL). The pH of the aqueous phase was adjusted with saturated sodium bicarbonate solution to 10. The aqueous phase was extracted with ethyl acetate (3 × 200 mL), the organic extracts were combined and dried with anhydrous magnesium sulfate. After concentration of the organic phase under reduced pressure, the crude product was purified by rapid chromatography on silica gel (eluent: 0-45% hexane solution of ethyl acetate) to afford 3-methyl-1H-indazole-5-carbonitrile as an orange solid (3.3 g, 21 mmol, 30% yield). Mass spectrum (ESI) m/z 158.2 [M + H]+.
References
[1] Patent: US2008/242694, 2008, A1. Location in patent: Page/Page column 67-68
1H-Indazole-5-carbonitrile, 3-methyl- Preparation Products And Raw materials
Raw materials
Preparation Products
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