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ACLARUBICIN HYDROCHLORIDE

Product Name
ACLARUBICIN HYDROCHLORIDE
CAS No.
75443-99-1
Chemical Name
ACLARUBICIN HYDROCHLORIDE
Synonyms
aclacinon;Aclarubicin HCl;Aclarubicin hydrochlride;ACLARUBICIN HYDROCHLORIDE;aclacinomycinahydrochloride;ACLARUBICIN HYDROCHLORIDE USP/EP/BP;Aclarubicin hydrochloride (Aclacinomycin A);syl)oxy)-2,5,7-trihydroxy-,methylester,hydrochloride,(1r-(1-alpha,2-beta,4;n-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyrano;1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-l-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-l-lyxo
CBNumber
CB2189954
Molecular Formula
C42H54ClNO15
Formula Weight
848.33
MOL File
75443-99-1.mol
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ACLARUBICIN HYDROCHLORIDE Property

Melting point:
151-153℃
Boiling point:
898℃
Flash point:
>110°(230°F)
storage temp. 
2-8°C
solubility 
Soluble in DMSO or DMF at 25mg/ml
form 
Solid
color 
Light yellow to yellow
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37/39-45
RIDADR 
3249
RTECS 
QI9283500
HazardClass 
6.1(a)
PackingGroup 
II
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P405Store locked up.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0079483
Product name
AclacinomycinAhydrochloride
Purity
98.08%
Packaging
5mg
Price
$280
Updated
2021/12/16
ChemScene
Product number
CS-0079483
Product name
AclacinomycinAhydrochloride
Purity
98.08%
Packaging
10mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-0079483
Product name
AclacinomycinAhydrochloride
Purity
98.08%
Packaging
25mg
Price
$980
Updated
2021/12/16
AK Scientific
Product number
0647CB
Product name
Aclarubicinhydrochloride
Packaging
10mg
Price
$1197
Updated
2021/12/16
ChemScene
Product number
CS-0079483
Product name
AclacinomycinAhydrochloride
Purity
98.08%
Packaging
50mg
Price
$1600
Updated
2021/12/16
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ACLARUBICIN HYDROCHLORIDE Chemical Properties,Usage,Production

Definition

ChEBI: Aclarubicin hydrochloride is an anthracycline.

Biological Activity

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) is a fluorescent molecule and the first non-peptidic inhibitor discovered to have discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. It is also a dual inhibitor of topoisomerase I and II (topoisomerase I and II). It is an effective anthracycline chemotherapeutic agent for blood cancer and solid tumor related research.

in vitro

Aclacinomycin A could efficiently enter living cells and emit fluorescence in situ . Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .

in vivo

Aclarubicin hydrochloride(Aclacinomycin A) is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD 50 (76.5 mg/kg) is about twice the iv LD 50 (35.6 mg/kg) in mice [4 .
Aclacinomycin A ( 0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model [4 .

td>
Animal Model: DBA/2, CDF 1 ( BALB/c×DBA/2) mice with Leukemia P-388 [4 .
Dosage: 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg.
Administration: Intraperit oneal administration daily for 10 days starting 3 hr after transplantation.
Result: Inhibited tumor growth.

target

20S proteasome.
Topoisomerase I and II.

ACLARUBICIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ACLARUBICIN HYDROCHLORIDE Suppliers

China 39 Japan 1 Switzerland 1 United Kingdom 1 United States 8 USA 1 Global 51
Shanghai Fuhe Chemistry Technology Co., Ltd.
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View Lastest Price from ACLARUBICIN HYDROCHLORIDE manufacturers

Dideu Industries Group Limited
Product
ACLARUBICIN HYDROCHLORIDE 75443-99-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-01
Shaanxi Dideu Medichem Co. Ltd
Product
Aclarubicin Hydrochloride 75443-99-1
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
800 ton
Release date
2020-04-30

75443-99-1, ACLARUBICIN HYDROCHLORIDERelated Search:

ACLARUBICIN HYDROCHLORIDE 3-Methylphenylacetic acid 1,8-Dihydroxyanthraquinone (S)-(+)-Ketoprofen Methyl 2,2-dimethylphenylacetate 1,2,3,4-Tetrahydro-1-naphthoic acid 2-HYDROXY-5-METHYLBENZOPHENONE (S)-(+)-1,2,3,4-Tetrahydro-1-naphthol Methyl salicylate 3-BENZOYLPHENYLACETIC ACID 2-Amylanthraquinone 3-METHOXYETHOXYPROPYLAMINE Aclarubicin 5-(4-METHYLPHENYL)VALERIC ACID (2RS)-2-(4-ETHYLPHENYL)PROPANOIC ACID 2H-PYRAN-3(4H)-ONE, DIHYDRO- L-DaunosamineHCl 2-(2,5-DIMETHYLPHENYL)ACETALDEHYDE

  • aclacinomycinahydrochloride
  • aclacinon
  • n-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyrano
  • syl)oxy)-2,5,7-trihydroxy-,methylester,hydrochloride,(1r-(1-alpha,2-beta,4
  • 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-l-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-l-lyxo
  • ACLARUBICIN HYDROCHLORIDE
  • 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, meth
  • 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, [1R-(1α,2β,4β)]-
  • Aclarubicin hydrochlride
  • Aclarubicin HCl
  • ACLARUBICIN HYDROCHLORIDE USP/EP/BP
  • Aclarubicin hydrochloride (Aclacinomycin A)
  • methyl(1R,2R,4S)-4-[(2R,4S,5S,6S)-4-(dimethylamino)-5-[(2S,4S,5S,6S)-4-hydroxy-6-methyl-5-[(2R,6S)-6-methyl-5-oxooxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate,hydrochloride
  • 75443-99-1
  • C42H54ClNO15
  • C42H53NO15HCl
  • API